Congratulations are due to Dr. Asma Nusrat, F. Peyton Rous Professor of Experimental Pathology and Director of Experimental Pathology, and Dr. Charles Parkos, Carl V. Weller Professor and Chair of Pathology, on being named 2022 American Association for the Advancement of Science Fellows. The AAAS is the world’s largest general scientific society and publisher of the Science family of journals. The 2022 class was comprised of 505 scientists, engineers and innovators from around the world and across all disciplines. Being selected as an AAAS Fellow is one of the most distinguished honors within the scientific community. The newly elected Fellows are being recognized for their scientific and socially notable achievements spanning their careers.
One of the most fascinating aspects of a career in cancer research is that one never knows when or where the next great discovery will occur. This was true of a recent breakthrough discovery made by the Dr. Russell Ryan laboratory at the University of Michigan Medical School. They were shocked to find that active regulatory elements in B-ALL contained not only typical protein binding sequences but also simple repeats of the sequence “GGAA”, usually considered a form of “junk DNA” with no regulatory function [...]
Members of the University of Michigan Department of Pathology and Michigan Center for Translational Pathology, in collaboration with the Clinical Proteomic Tumor Analysis Consortium, recently published a large study on clear cell renal cell carcinomas (ccRCCs), which represent about 75% of the RCC cases and account for the most RCC-associated deaths. This study set out to create a comprehensive profile of ccRCC, combining histologic and molecular profiles. By analyzing both the microscopic cell structures and the genetic makeup of the cells, these researchers discovered significant intratumoral heterogeneity in 90% of ccRCCs. This indicates that ccRCCs originate from multiple tumor cell lines, called tumor subclones, that may become metastatic and could independently influence response to therapies. Through this study, the team was able to molecularly stratify aggressive histopathic subtypes, which may lead to more effective treatment strategies for patients and improved survival.
A research team from the Michigan Center for Translational Pathology undertook a study to illustrate how careful assessment of cytologic and biomarker features may provide physicians with information on Metastatic Prostatic Cancer (MCP) patients’ prognosis and the best therapies to consider [...]
We are pleased to share that the Board of Regents today (Oct. 20) approved the appointment of Zaneta Nikolovska-Coleska, M.S., Ph.D., as associate dean for graduate and postdoctoral studies in the Medical School, effective Oct. 1, 2022. Please join us in congratulating Dr. Nikolovska-Coleska on her associate dean role.
The University of Michigan’s Protein Folding Diseases Initiative Symposium will be holding its 9th Annual Symposium starting at 9 am.
The Celina Kleer lab at the University of Michigan Department of Pathology and Rogel Cancer Center has found a new mechanism that fuels metastasis in triple negative breast cancers. In their new study they show that EZH2, a master regulator of cell type identity, known to function through methylation of histones, has a new, unexpected function in aggressive breast cancers [...]
The role of artificial intelligence (AI) in healthcare continues to expand. In a recent issue of BMC Cancer, Dr. Vipulkumar Dadhania (first author) and colleagues published a result of their study Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer. The expert team from the Michigan Center for Translational Pathology developed a deep-learning-based model to predict ERG genomic rearrangements in prostatic adenocarcinomas using only H&E-stained digital slides [...]
Please join us in congratulating Dr. Abhijit Parolia on being selected for the 2022 Harold Weintraub Graduate Student Award. The award, established by the Fred Hutchinson Cancer Research Center, is given yearly and recognizes outstanding achievement during graduate studies in the biological sciences [...]
A study related to the maternal gut microbiome and how it regulates immunity to respiratory syncytial virus (RSV) infections in offspring was recently published in the Journal of Experimental Medicine. Clinical experts from the Department of Pathology including Drs. Wendy Fonseca, Nicholas Lukacs, and Catherine Ptaschinski were responsible for carrying out this study [...]
Metformin holds promise against a rare type of childhood brain tumor in laboratory studies, as per an international team of researchers led by Dr. Sriram Venneti report in Science Translational Medicine. [...]
Dr. Peter Ward, Active Emeritus Professor and former Chair of Pathology, was named “World Expert in Sepsis” by Expertscape on World Sepsis Day, September 13, 2021. To be named a World Expert, one must be in the top 0.1% of scholars writing about Sepsis over the past ten years. Ward came in among the top .006% of scholars in the world and the number 1 scholar on sepsis at the University of Michigan [...]
The Department of Pathology's 2020 Annual Report is now available online. In the report, you will read about the department’s tripartite mission of research, education, and patient care, and learn about the goals of the department’s Strategic Council [...]
Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]
A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes.
Congratulations to Dr. Thomas Giordano and the entire Cancer Genome Atlas Project team for winning the American Association of Cancer Research's 2020 Team Science Award [...]
Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]
Diarrhea can be the unfortunate but short-lived side effect of bad takeout food, yet it is also a leading cause of death in children under five globally. Scientists continue to investigate how illness-causing bacteria gain a foothold within the digestive tract when they are usually held in check by the protective bacteria collectively known as the gut microbiome [...]
In a new study, Chan Chung et al. from the Venneti laboratory have discovered a “catch 22”-like phenomena, where epigenetic and metabolic pathways feed one another, in a childhood brain tumor called Diffuse Intrinsic Pontine Gliomas (DIPG) [...]
New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]
Research from Dr. Analisa Difeo was just published in Nature Communications. The study focuses on miR-181a and how it initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling [...]
The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.
The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.
The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.
The research was just published in Histopathology and features prominent contributions from our faculty.
The Department of Pathology 2019 Annual Report is now available online. Our department continues to show outstanding performance and growth and the past year was another example of why our department is one of the best in the world.
In the report, you will read about [...]
The study sheds light on alternative methods used for measuring size and depth of vulvar squamous cell carcinoma.
Along with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]
Congratulations to Arul M. Chinnaiyan, MD, PhD, on his election to the National Academy of Science! Chinnaiyan is an investigator, Howard Hughes Medical Institute; and S.P. Hicks Endowed Professor of Pathology, American Cancer Society Research Professor, and director, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor [...]
A new study from the Andrew Lieberman Laboratory’s Samir Nath, et al, has discovered that MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
Kennedy’s Disease, also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a disease caused by an inherited gene mutation that results in muscle and brain cell dysfunction. Patients progressively lose muscle mass until they are unable to walk without assistance. Ultimately [...]
A new study from Dr. Rajan Dewar of the Department of Pathology has found that inactivated virus transporation should be implemented for safe transportation and handling at diagnostics laboratories.
The study details research surrounding Respiratory Syncytial Virus (RSV) among infants.
Resolvin E1 (RvE1), a lipid derived from Omega-3 fatty acids, is a pro-repair molecule that promotes healing of intestinal wounds according to a recent study published in PNAS as a collaborative project between The Department of Pathology at the University of Michigan Medical School and [...]
Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.
PTM Therapeutics, Inc. celebrated on February 6th the signing of an exclusive license for an antibody (PTM-001) jointly from the University of Michigan and Emory University during a bell-ringing ceremony at University of Michigan Tech Transfer. The startup is [...]
A recent report based on a phase I clinical trial by Dr. Aslam, et al, in the Varani Laboratory shows that a multi-mineral supplement, Aquamin®, modulates the colonic microbial community in human subjects. This study is part of an ongoing effort to determine if multi-mineral intervention [...]
A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.
Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]
In 2015, Felipe da Veiga Leprevost, PhD, came to the University of Michigan as a research fellow to study computational proteomics. In June of 2019, he accepted a faculty position as a Research Investigator in Bioinformatics. He now has a Michigan-born little one and his roots are growing deeper in Ann Arbor [...]
Dr. Gabriel Nuñez, the Paul de Kruif Endowed Professor of Pathology, is one of the newest members of the National Academy of Medicine. The Nuñez laboratory has made ground-breaking discoveries in the field of [...]
Congratulations to Steven L. Kunkel, PhD, on his appointment as the executive vice dean for research and chief scientific officer of the University of Michigan Medical School, effective September 1, 2019, following a nationwide search for the best candidate. Kunkel previously served [...]
Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]
Every year in the United States, nearly 3 million men hear the words, “You have prostate cancer.” That is 1 in 9 men each year. The word “cancer” triggers an immediate response in most people…fear, worry about family, denial, and often an increased awareness of one’s mortality. [...]
In November 2018, postdoctoral fellow Jay Vornhagen, PhD, was appointed as the first Department of Pathology Medical School Postdoctoral Trainee Senator. The Medical School Postdoctoral Trainee Senate is a volunteer organization [...]
Cancer biologists and engineers collaborated on a device that could help predict the likelihood of breast cancer metastasis.
Congratulations to Jolanta Gembecka, PhD, who is one of fourteen in the inaugural class of Rogel Scholars! As part of the commitment from Richard and Susan Rogel, researchers will have the opportunity and freedom to pursue new directions in their work. Dr. Grembecka's research focus is developing [...]
A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.
A U-M study is the first to define how a little-known type of cell death impacts tumor cells and immune cells.
The Department of Pathology was well-represented at the American Society for Investigative Pathology’s 2019 Annual Meeting.
Dr. Charles Parkos, Carl V. Weller Professor and Chair of the Department of Pathology, has been inducted into the Association of American Physicians (AAP). Founded in 1885, the AAP is an organization of leading senior physician-scientists [...]
If a picture's worth a thousand words, a video is perhaps worth much more.
Eric Fearon, MD, PhD , and Thomas Glover, PhD, are two of fifteen researchers at the University of Michigan named 2018 American Association for the Advancement of Science (AAAS) Fellows. A total of 416 members were awarded for 2018, chosen by their peers for their [...]
Dr. Kathleen Cho received a five-year R01 grant from the National Institutes of Health (NIH) to continue her work in ovarian cancer research. High-grade serous carcinoma, or HGSC, is both the most common and most deadly form of “ovarian” cancer, although it is now believed that most HGSCs arise [...]
Tomasz Cierpicki, PhD, has been awarded an RO1 with five years of funding from the National Cancer Institute for his grant application, Targeting NSD1 In Leukemia, to develop inhibitors of NSD1 histone [...]
Jiaqi Shi, MD, PhD, has been awarded a KO8 (Career Development Award) from the National Cancer Institute for her grant application, Linking epigenetic regulation and TGF-β signaling in [...]
The American Society of Hematology (ASH) has chosen Dr. Russell Ryan as a recipient of its Junior Faculty Scholar Award in Basic/Translational Research. Established more than 30 years ago, the Scholar Awards program is one of [...]
Dr. Zaneta Nikolovska-Coleska’s work was highlighted as part of the Featured Technology and Startup Kiosks during the University of Michigan Tech Transfer’s annual Celebrate Invention event on October 17th at the Michigan League. Nikolovska-Coleska’s project, Discovery of Mc1-1 inhibitors from integrated [...]
Precision Health at the University of Michigan has chosen Dr. Jeffrey Hodgin as one of ten recipients of its Investigators Awards. The grants, totaling nearly $3 million, are of up to $300,000 each [...]
On Sunday, October 21, Jim Harbaugh, head coach of University of Michigan football, greeted 125 surprised attendees of the Pathology Investigators, Students and Academicians (PISA) Conference being hosted by the University of Michigan at the A. Alfred Taubman Biomedical Science Research Building in Ann Arbor. PISA attendees [...]
A recent collaborative study out of the Michigan Center for Translational Pathology (MCTP) has led to new insight into kidney cancer. The resulting paper, VSTM2A Overexpression is a Sensitive and Specific Biomarker for [...]
In this episode of Careers in Pathology, Dr. Taeko Noah talks about her work in the Hogan Lab researching food allergies. Dr. Noah is a cellular biologist working as a Research Scientist in Pathology, studying how food crosses the intestinal epithelium to trigger allergic reactions.
The University of Michigan SPORE in Prostate Cancer has awarded Aaron Udager, MD, PhD, with a two-year Prostate SPORE Career Enhancement Program (CEP) grant of $60,00 per year. The Department of Pathology will contribute matching funds of another [...]
The laboratory of Dr. Chang Kim, along with colleagues from Purdue University and the Indiana University School of Medicine, has published in Nature [...]
A collaboration out of the Molecular and Cellular Pathology graduate program could lead to new treatment strategies.
Funding to Chinnaiyan supports evaluating new cancer markers that could become treatment targets.
Triple-negative breast cancers account for just 15-20% of breast cancers, but a disproportionate number of deaths. A Nature Communications paper from the Kleer Lab, in close collaboration with other U-M Department of Pathology labs, has discovered a reason why and could lead to better outcomes for patients.
Celina Kleer, MD’s lab in the Rogel Cancer Center is occupied by staff and students with a range of experiences and talents, but a common goal – understanding difficult breast cancers [...]
Thomas Giordano, MD, PhD, the Henry Clay Bryant Professor of Pathology, has published an invited review article in a special issue of Endocrine-Related Cancer, celebrating 65 years of the double helix. In Classification of endocrine tumors in the age of integrated genomics, Giordano shares [...]
Congratulations to Asma Nusrat, MD, the Aldred Scott Warthin Professor and director of experimental pathology in the Michigan Medicine Department of Pathology, for her election as president of the American Society for Pathology for [...]
Dr. Gabriel Nuñez, the Paul de Kruif Endowed Professor of Inflammation & Immunology and Co-Director of Immunology and Host Response Program in the Michigan Medicine Department of Pathology, has been [...]
Congratulations to Dean Steven Kunkel on his appointment as Distinguished University Professor, one of the University of Michigan's highest honors, and being recognized for his exceptional achievements and services. He was one of five professors honored this year, effective September 1, 2018.
A life insurance policy purchased in the seventies is being used to recognize resident achievement today.
Congratulations to Dr. Nick Lukacs, the Godfrey D. Stobbe Professor of Pathology, Assistant Dean for Faculty Affairs and the Scientific Director of the Mary H. Weiser Food Allergy Center, for his nomination and selection for the 2018 MICHR Distinguished Mentorship Award!
Lukacs was nominated by his trainees and peers at the [...]
Congratulations to Dr. Celina Kleer, the Harold A. Oberman Collegiate Professor of Pathology, who has been selected as the 2018 recipient of the 7th Annual MICHR Distinguished Clinical and Translational Research Mentor Award!
Dr. Kleer was nominated by her trainees as well as peers at U-M Medical [...]
The Department of Pathology and the American Society for Investigative Pathology (ASIP) are proud to host the interactive, abstract-driven 2018 Pathobiology for Investigators, Students and Academicians Conference (PISA), in Ann Arbor, Michigan on October 20-22 [...]
Researchers identify a lncRNA that provides insight into a key driver of prostate cancer — and a potential target for future therapy.
Molecular and Celluar Pathology (MCP) Students Siva Kumar Natarajan, Paloma Garcia, and Kelly Kennaley took earned valuable experience and took top prizes during the 4th Annual Midwest Case Competition.
Molecular and Cellular Pathology Graduate Program student, Emmalee Adelman, successfully defended her PhD thesis on April 9. Widespread epigenetic reprogramming in aging human hematopoietic stem cells, covers her work [...]
A decade-long effort to genomically characterize multiple cancers begets a huge archive.
Arul Chinnaiyan, MD, PhD and Rohit Mehra, MD are contributing authors of a new paper, Comprehensive evaluation of PD-L1 expression in primary and metastatic prostate cancer, published in The American Journal of [...]
The desire to propel her research has brought Maria Westerhoff, MD to the University of Michigan
Recent discoveries about how the immune system reacts to injury — and the dire consequences
if that response spirals out of control — could help improve trauma care
Dr. Charles Parkos was part of a delegation representing the Federation of American Societies for Experimental Biology (FASEB) on March 8, 2018 in Washington, D.C. to advocate for increased funding for research[...]
Richard Miller MD, PhD, has been elected into the Association of American Physicians (AAP). The AAP is a non-profit, professional organization founded in 1885 for “the advancement of scientific and practical medicine.” The Association is composed of members who are leading senior physician-scientists and are [...]
Andrew Lieberman, MD, PhD, Gerald D. Abrams Collegiate Professor and Director of Neuropathology, has been elected to serve on the Neuropathology Core Steering Committee of the National Alzheimer’s Coordinating Center (NACC). The goal of the [...]
Newborns are highly susceptible to enteric infections. It was assumed this was due to immaturity of their immune systems but new research in the laboratory of Dr. Gabriel Nunez, Paul de Kruif Professor of Academic Pathology, suggests otherwise.
Congratulations to Molecular and Cellular Pathology PhD student, Hung-An (Ana) Ting, in the laboratory of Dr. Nicholas Lukacs, whose work on “Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection" is featured in the “In This Issue” section of the February 15, 2017 issue of The Journal of Immunology. The “In This Issue” highlights articles considered to be among the top 10% of articles published in the journal. Their work is on regulating lung pathology with the Notch pathway.
The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, discovered that mammary-specific knock down of CCN6 results in mammary carcinomas with features of human metaplastic carcinomas. This model may lead to discovery of new diagnostic and therapeutic targets for this rare and aggressive form of triple negative breast cancer. The article appeared in Oncogene, on the November 7th 2016 issue, and can be found at www.nature.com
The laboratory of Dr. Tomasz Cierpicki has determined the structure of BMI1 protein in complex with PHC2 and characterized its role in regulation of the architecture and activity of the PRC1. The article "BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization" has been published in Nature Communications. Co-first authors are Felicia Gray, Hyo-Je Cho and Shirish Shukla, and this is a collaborative study with Dr. Grembecka and Dr. Lawlor from the Department of Pathology.
Congratulations to the Nusrat/Parkos Lab on having the cover image of the September 2016 issue of Mucosal Immunology. The image is from their article, Neutrophil interactions with epithelial expressed ICAM-1 enhances intestinal mucosal wound healing.
You can read more at nature.com.
Dr. Thomas Giordano, M.D., Ph.D, the Henry Clay Bryant Professor of Pathology, led an international study on the genomics of adrenal cancer. The project was one of the 33 projects that comprise The Cancer Genome Atlas (TCGA) project of the NCI and NHGRI. The study results were published in Cancer Cell.
The laboratory of Dr. Yali Dou, Ph.D., Associate Professor of Pathology, reported new findings in the article “PRDM16 suppresses MLL1r leukemia via intrinsic histone methyltransferase activity” which was published in the journal Molecular Cell on April 27th, 2016. Dr. Bo Zhou is the first author. Other co-authors from the Department include Shirley Y. Lee, Yuqing Sun, and Rajesh C. Rao. The article can be found online at:
Assistant Professor, Sriram Venneti, MD, PhD, was named a Kimmel Scholar by the Sidney Kimmel Foundation. The Kimmel Scholar Awards are given annually to 15 innovative research scientists and medical doctors in the U.S. who are in the early stages of their careers. Dr. Venneti will receive a $200,000 grant for his work, titled, “Metabolic regulation of epigenetics in childhood brain tumors.” Congratulations, Dr. Venneti, on being recognized as one of the country’s most promising young cancer researchers!
Congratulations to Dr. Asma Nusrat, Director of Experimental Pathology on her election as Vice President of the American Society for Investigative Pathology (ASIP). Her term is effective July 1, 2016 after which she will become President elect, then President on July 1, 2018. Dr. Nusrat has been a productive member of the ASIP community for over a decade participating in many program committees and task forces. Her commitment to enhance experimental pathology and translational medicine is admirable as evidenced by her work as the program committee chair for ASIP and PISA (Pathobiology for Investigators, Students, and Academicians) conference. Please join us in congratulating her on this prestigious national leadership appointment in Experimental Pathology
Description: The Department of Pathology invites applications from faculty with primary appointment in Pathology for proteomics related Pilot Projects that intend to use the state-of-the-art Proteomics Resource Facility (PRF) at the University of Michigan Medical School that is led by Dr. Alexey Nesvizhskii. Funds are primarily meant to help offset the cost of proteomic experiments, the results of which could potentially form the basis for or strengthen an extramural grant application. The grant is a cost share (2/3 funded by Department of Pathology and 1/3 by the investigator).
Who Can Apply: Department of Pathology Faculty
Applications will be accepted on a rolling basis and reviewed on a monthly basis. Applications received by Monday February 29, 2016 will be reviewed by March 8, 2016.
More information about this opportunity can be found by Clicking Here
The laboratory of Dr. Gabriel Nuñez, Paul de Kruif Professor of Pathology, reported new findings in the article “NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux” which was published as an advance online publication in the journal Nature on January 27, 2016. Dr. Yuan He is the first author. Other co-authors from the Department include Dr. Melody Zeng and Dr. Dahai Yang. The article can be found online here at http://www.nature.com.
Last week we were thrilled to learn that Jeff Hodgin is this year’s recipient of the Gloria Gallo Research Award, an award given by the Renal Pathology Society in honor of one of its founding members for the most impactful research program. He received the award at the annual meeting of the American Society of Nephrology. In the words of Matthias Kretzler, Warner-Lambert/Parke-Davis Professor of Medicine and Jeff’s scientific mentor . . .
The 14th Annual Pathology Research Symposium, organized and hosted by the Pathology Graduate Student Council, and sponsored by the Molecular and Cellular Pathology Graduate Program in the Department of Pathology at the University of Michigan will take place, Thursday, Nov. 5, 2015, from 9:30am to 4:15pm at the Palmer Commons Auditorium.
The highest honor bestowed by the University of Michigan Medical School was presented to Eric Fearon, MD, PhD as he received the Distinguished Faculty Lectureship Award. Given to an extraordinary leader in research whose scientific contributions are pivotal in advancing their field of scientific knowledge, this award also recognizes excellence in teaching, mentoring and service to the institution at large.
Click Here for more info on the event.
The 2nd Annual Protein Folding Diseases Initiative Symposium, “Molecules and Machines”, was held on Friday, September 18, 2015, at the A. Alfred Taubman Biomedical Science Research Building.
The University of Michigan Protein Folding Diseases Initiative (PFDI), lead by Drs. Andrew Lieberman and Henry Paulson, seeks to connect the diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”