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By Cannibalizing Nearby Stromal Stem Cells, Some Breast Cancer Cells Gain Invasion Advantage
Cancer biologists and engineers collaborated on a device that could help predict the likelihood of breast cancer metastasis.
Newly Defined Cancer Driver is Fast, Furious, and Loud
Researchers characterize 3 ways in which the gene FOXA1 mutates to trigger prostate cancer.
Jolanta Grembecka, PhD, Among 14 Inaugural Rogel Scholars
Congratulations to Jolanta Gembecka, PhD, who is one of fourteen in the inaugural class of Rogel Scholars! As part of the commitment from Richard and Susan Rogel, researchers will have the opportunity and freedom to pursue new directions in their work. Dr. Grembecka's research focus is developing [...]
U-M Compounds Show Promise in a Lab Model of Advanced Prostate Cancer
A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.
Researchers Find New Target to Improve Response to Cancer Immunotherapy
A U-M study is the first to define how a little-known type of cell death impacts tumor cells and immune cells.
Department Among Leadership, Award Winners, at ASIP Annual Meeting
The Department of Pathology was well-represented at the American Society for Investigative Pathology’s 2019 Annual Meeting.
Dr. Charles Parkos Inducted into Association of American Physicians
Dr. Charles Parkos, Carl V. Weller Professor and Chair of the Department of Pathology, has been inducted into the Association of American Physicians (AAP). Founded in 1885, the AAP is an organization of leading senior physician-scientists [...]
Witnessing the dance of RNAs around droplets of cellular degradation machinery
If a picture's worth a thousand words, a video is perhaps worth much more.
Glover and Fearon Honored for AAAS Fellowships at Annual Meeting
Eric Fearon, MD, PhD , and Thomas Glover, PhD, are two of fifteen researchers at the University of Michigan named 2018 American Association for the Advancement of Science (AAAS) Fellows. A total of 416 members were awarded for 2018, chosen by their peers for their [...]
Creating Hope
Mark Schultz, PhD strives to create therapeutics for Niemann-Pick disease.
Circular RNA Holds Promise as Cancer Biomarker
Unique structure of circRNA makes it an ideal candidate for biomarkers – and it can be detected in blood or urine.
Kathleen Cho, MD, Receives R01 Grant for Ovarian Cancer Research
Dr. Kathleen Cho received a five-year R01 grant from the National Institutes of Health (NIH) to continue her work in ovarian cancer research. High-grade serous carcinoma, or HGSC, is both the most common and most deadly form of “ovarian” cancer, although it is now believed that most HGSCs arise [...]
Tomasz Cierpicki Awarded NIH Research Project Grant
Tomasz Cierpicki, PhD, has been awarded an RO1 with five years of funding from the National Cancer Institute for his grant application, Targeting NSD1 In Leukemia, to develop inhibitors of NSD1 histone [...]
Jiaqi Shi Awarded Grant from the National Cancer Institute
Jiaqi Shi, MD, PhD, has been awarded a KO8 (Career Development Award) from the National Cancer Institute for her grant application, Linking epigenetic regulation and TGF-β signaling in [...]
Russell Ryan, MD receives ASH Junior Faculty Scholar Award
The American Society of Hematology (ASH) has chosen Dr. Russell Ryan as a recipient of its Junior Faculty Scholar Award in Basic/Translational Research. Established more than 30 years ago, the Scholar Awards program is one of [...]
Discovery out of Nikolovska-Coleska Lab featured at Celebrate Invention
Dr. Zaneta Nikolovska-Coleska’s work was highlighted as part of the Featured Technology and Startup Kiosks during the University of Michigan Tech Transfer’s annual Celebrate Invention event on October 17th at the Michigan League. Nikolovska-Coleska’s project, Discovery of Mc1-1 inhibitors from integrated [...]
Dr. Jeffrey Hodgin awarded U-M Precision Health Investigator Grant
Precision Health at the University of Michigan has chosen Dr. Jeffrey Hodgin as one of ten recipients of its Investigators Awards. The grants, totaling nearly $3 million, are of up to $300,000 each [...]
Jim Harbaugh meets with scientists at Michigan Stadium
On Sunday, October 21, Jim Harbaugh, head coach of University of Michigan football, greeted 125 surprised attendees of the Pathology Investigators, Students and Academicians (PISA) Conference being hosted by the University of Michigan at the A. Alfred Taubman Biomedical Science Research Building in Ann Arbor. PISA attendees [...]
Team Led by Dr. Rohit Mehra discovers New Diagnostic Biomarker for Kidney Cancer
A recent collaborative study out of the Michigan Center for Translational Pathology (MCTP) has led to new insight into kidney cancer. The resulting paper, VSTM2A Overexpression is a Sensitive and Specific Biomarker for [...]
Careers in Pathology: Dr. Taeko Noah
In this episode of Careers in Pathology, Dr. Taeko Noah talks about her work in the Hogan Lab researching food allergies. Dr. Noah is a cellular biologist working as a Research Scientist in Pathology, studying how food crosses the intestinal epithelium to trigger allergic reactions.
Dr. Udager receives Grant from U-M Prostate SPORE
The University of Michigan SPORE in Prostate Cancer has awarded Aaron Udager, MD, PhD, with a two-year Prostate SPORE Career Enhancement Program (CEP) grant of $60,00 per year. The Department of Pathology will contribute matching funds of another [...]
Research from the Kim Lab published in Nature Communications
The laboratory of Dr. Chang Kim, along with colleagues from Purdue University and the Indiana University School of Medicine, has published in Nature [...]
New Mechanism in Aggressive Breast Cancer Discovered
A collaboration out of the Molecular and Cellular Pathology graduate program could lead to new treatment strategies.
Stories Found in Tissues
Simon Hogan, PhD, unlocks the Secrets of Allergic Diseases.
U-M cancer researcher awarded $6.5M Outstanding Investigator Award to explore precision oncology
Funding to Chinnaiyan supports evaluating new cancer markers that could become treatment targets.
Pathobiology for Investigators, Students and Academicians (PISA) Conference
The Department of Pathology and the American Society for Investigative Pathology (ASIP) are proud to host the interactive, abstract-driven 2018 Pathobiology for Investigators, Students and Academicians Conference (PISA), in Ann Arbor, Michigan. This year’s event, Molecular Mechanisms of Disease: Tissue Homeostasis, Immune Responses and Cancer.
She Designed a Life She Loves
The story of how Kathleen R. Cho, MD, created a career in which she excels at diagnostics, research, and administration.
5th Annual Protein Folding Diseases Initiative Symposium
The University of Michigan’s Protein Folding Diseases Initiative will be holding its 5th Annual Symposium on Thursday, October 11, from 8:30 am until 4:30 pm, at the A. Alfred Taubman Biomedical Science Research Building (BSRB), Kahn Auditorium, on the University’s Medical Campus.
Fall Orientation for Clinical Investigators
8:00 am – 11:30 am | University Hospital Room UH 2C224
Dr. Giordano Published in Endocrine-Related Cancer
Thomas Giordano, MD, PhD, the Henry Clay Bryant Professor of Pathology, has published an invited review article in a special issue of Endocrine-Related Cancer, celebrating 65 years of the double helix. In Classification of endocrine tumors in the age of integrated genomics, Giordano shares [...]
Dr. Asma Nusrat elected President of the American Society for Investigative Pathology
Congratulations to Asma Nusrat, MD, the Aldred Scott Warthin Professor and director of experimental pathology in the Michigan Medicine Department of Pathology, for her election as president of the American Society for Pathology for [...]
Dr. Gabriel Nuñez selected for the 2019 Rous-Whipple Award from the American Society for Investigative Pathology
Dr. Gabriel Nuñez, the Paul de Kruif Endowed Professor of Inflammation & Immunology and Co-Director of Immunology and Host Response Program in the Michigan Medicine Department of Pathology, has been [...]
Dr. Steven L. Kunkel Appointed as Distinguished University Professor
Congratulations to Dean Steven Kunkel on his appointment as Distinguished University Professor, one of the University of Michigan's highest honors, and being recognized for his exceptional achievements and services. He was one of five professors honored this year, effective September 1, 2018.
Philip Giesen Award and Lecture Highlights Pathology’s Commitment to Supporting Trainee Research
A life insurance policy purchased in the seventies is being used to recognize resident achievement today.
Dr. Khatri et al. Published in the Journal of the American Academy of Dermatology
Dr. Sameer Khatri along with the Department of Pathology's Drs. Min Wang, Paul Harms, Douglas Fullen, Aleodor Andea, and May Chan, in collaboration with other U-M [...]
Dr. Nick Lukacs selected for the 2018 MICHR Distinguished Mentorship Award
Congratulations to Dr. Nick Lukacs, the Godfrey D. Stobbe Professor of Pathology, Assistant Dean for Faculty Affairs and the Scientific Director of the Mary H. Weiser Food Allergy Center, for his nomination and selection for the 2018 MICHR Distinguished Mentorship Award!
Lukacs was nominated by his trainees and peers at the [...]
Celina G. Kleer, MD selected for the 2018 MICHR Distinguished Clinical and Translational Research Mentor Award
Congratulations to Dr. Celina Kleer, the Harold A. Oberman Collegiate Professor of Pathology, who has been selected as the 2018 recipient of the 7th Annual MICHR Distinguished Clinical and Translational Research Mentor Award!
Dr. Kleer was nominated by her trainees as well as peers at U-M Medical [...]
Department Co-Hosting the 2018 PISA Conference
The Department of Pathology and the American Society for Investigative Pathology (ASIP) are proud to host the interactive, abstract-driven 2018 Pathobiology for Investigators, Students and Academicians Conference (PISA), in Ann Arbor, Michigan on October 20-22 [...]
Genome's Dark Matter Sheds Light on Prostate Cancer Challenge
Researchers identify a lncRNA that provides insight into a key driver of prostate cancer — and a potential target for future therapy.
MCP Students Take Top Prizes at 4th Annual Midwest Case Competition
Molecular and Celluar Pathology (MCP) Students Siva Kumar Natarajan, Paloma Garcia, and Kelly Kennaley took earned valuable experience and took top prizes during the 4th Annual Midwest Case Competition.
Join Us in Congratulating Emmalee Adelman, PhD
Molecular and Cellular Pathology Graduate Program student, Emmalee Adelman, successfully defended her PhD thesis on April 9. Widespread epigenetic reprogramming in aging human hematopoietic stem cells, covers her work [...]
How The Cancer Genome Atlas Will Shape the Future of Cancer Research
A decade-long effort to genomically characterize multiple cancers begets a huge archive.
Chinnaiyan and Mehra Contribute to Paper on PD-L1 Expression
Arul Chinnaiyan, MD, PhD and Rohit Mehra, MD are contributing authors of a new paper, Comprehensive evaluation of PD-L1 expression in primary and metastatic prostate cancer, published in The American Journal of [...]
New Gastrointestinal Pathologist Strives for Excellence and Joie De Vivre
The desire to propel her research has brought Maria Westerhoff, MD to the University of Michigan
Women’s History Month - Ruth C. Wanstrom, MD
Highlighting one of the first female University of Michigan Department of Pathology faculty.
World TB Day – Wanted: Leaders for a TB-Free World
Pathology's involvement in tuberculosis research and diagnosis
Improving Trauma Survival Hinges on the Body's Own First Responders
Recent discoveries about how the immune system reacts to injury — and the dire consequences
if that response spirals out of control — could help improve trauma care
Dr. Parkos Visits Capitol Hill to Advocate for Increased Research Funding
Dr. Charles Parkos was part of a delegation representing the Federation of American Societies for Experimental Biology (FASEB) on March 8, 2018 in Washington, D.C. to advocate for increased funding for research[...]
Richard Miller, MD, PhD Elected Into Association of American Physicians
Richard Miller MD, PhD, has been elected into the Association of American Physicians (AAP). The AAP is a non-profit, professional organization founded in 1885 for “the advancement of scientific and practical medicine.” The Association is composed of members who are leading senior physician-scientists and are [...]
DIPG Tumor Patterns Offer New Insight on Survival
finds an overlooked key factor in determining prognosis
for the aggressive childhood brain cancer.
Modern Pathology Cover Features Research by Mehra, Skala, and Team
Clinical FISH Assays for TFE3 and TFEB Help Characterize Renal Cell Carcinoma.
Andrew Lieberman, MD, PhD Elected to National Neuropathology Core Steering Committee
Andrew Lieberman, MD, PhD, Gerald D. Abrams Collegiate Professor and Director of Neuropathology, has been elected to serve on the Neuropathology Core Steering Committee of the National Alzheimer’s Coordinating Center (NACC). The goal of the [...]
Dr. Sriram Venneti Receives Sontag Foundation Distinguished Scientist Award
Nusrat Lab and Collaborators Publish on Human Intestinal Organoid Generation in Nature Cell Biology
Study by Russell Ryan and Colleagues Links Mutations in Notch Gene to Role in B Cell Cancers
Michael Garratt, PhD, Receives $50,000 AFAR Research Grant for Junior Faculty
Rual Lab Publishes in The EMBO Journal
Nisha D'Silva, PhD Awarded 8.1M Grant for Cancer Research
Free Translational Research Symposium on October 4
Hear about the future of translational research from keynote speaker, Christopher P. Austin, MD, Director of the National Center for Advancing Translational Sciences at the National Institutes of Health. You'll learn [...]
Fight Food Allergies at FARE’s Food Allergy Heroes Walk
PhD Student, Paloma Garcia, Awarded F31 Fellowship
Jacqueline Mann of Nesvizhskii Lab Awarded NIH F31 Fellowship
Nick Lukacs, PhD Named President-Elect of Society for Leukocyte Biology
Chinnaiyan Lab PhD Students Receive Department of Defense Awards
Dressler Lab Publishes on KCP in Journal of Biological Chemistry
Paper from Dressler Lab Shows Inhibition of Pax2 Transcription Activation
Research from the Chinnaiyan Lab on the Cover of Nature
Michigan Legacy Tissue Program to Expand Patient Contribution and Clinical Research
Study by Postdoc in Nusrat Lab Published in The Journal of Clinical Investigation
Quiros and colleagues showed that IL-10 generated by monocytes recruited into healing wounds plays a fundamental role in [...]
Stephanie Skala, MD and Team Publish Work on Upper Tract Urothelial Carcinoma
Grant Establishes Proteogenomics Center at U-M
Student in Dr. Arul Chinnaiyan's Lab Awarded NIH F30 Fellowship
Understanding Pediatric Brain Cancer
order to better understand and eventually treat childhood cancer.
Team Led by Rohit Mehra, MD Publishes in the American Journal of Surgical Pathology
Nunez Lab Reports in the Journal Science: Gut Bacteria May Explain Increased Susceptibility of Newborns to Infection
Newborns are highly susceptible to enteric infections. It was assumed this was due to immaturity of their immune systems but new research in the laboratory of Dr. Gabriel Nunez, Paul de Kruif Professor of Academic Pathology, suggests otherwise.
Sriram Venneti receives ASCI young Physician-Scientist Award
Senior resident publishes Breast Pathology consultation practice at Michigan Medicine
A Star from the Beginning – Arul Chinnaiyan, MD, PhD leads multipronged exploration of cancer’s molecular drivers
Work of PhD Candidate Ana Ting featured in The Journal of Immunology
Congratulations to Molecular and Cellular Pathology PhD student, Hung-An (Ana) Ting, in the laboratory of Dr. Nicholas Lukacs, whose work on “Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection" is featured in the “In This Issue” section of the February 15, 2017 issue of The Journal of Immunology. The “In This Issue” highlights articles considered to be among the top 10% of articles published in the journal. Their work is on regulating lung pathology with the Notch pathway.
Kleer lab develops model of human metaplastic breast carcinomas
The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, discovered that mammary-specific knock down of CCN6 results in mammary carcinomas with features of human metaplastic carcinomas. This model may lead to discovery of new diagnostic and therapeutic targets for this rare and aggressive form of triple negative breast cancer. The article appeared in Oncogene, on the November 7th 2016 issue, and can be found at www.nature.com
Pathology Laboratory Reports Structure of BMI1-PHC2 complex
The laboratory of Dr. Tomasz Cierpicki has determined the structure of BMI1 protein in complex with PHC2 and characterized its role in regulation of the architecture and activity of the PRC1. The article "BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization" has been published in Nature Communications. Co-first authors are Felicia Gray, Hyo-Je Cho and Shirish Shukla, and this is a collaborative study with Dr. Grembecka and Dr. Lawlor from the Department of Pathology.
UM Lab’s work lands the cover of Mucosal Immunology
Congratulations to the Nusrat/Parkos Lab on having the cover image of the September 2016 issue of Mucosal Immunology. The image is from their article, Neutrophil interactions with epithelial expressed ICAM-1 enhances intestinal mucosal wound healing.
You can read more at nature.com.
International collaboration leads to clues about rare cancer
Dr. Thomas Giordano, M.D., Ph.D, the Henry Clay Bryant Professor of Pathology, led an international study on the genomics of adrenal cancer. The project was one of the 33 projects that comprise The Cancer Genome Atlas (TCGA) project of the NCI and NHGRI. The study results were published in Cancer Cell.
View the full article online from mcancer.org OR labblog.uofmhealth.org
Pathology Laboratory Reports New Findings in the Journal Molecular Cell
The laboratory of Dr. Yali Dou, Ph.D., Associate Professor of Pathology, reported new findings in the article “PRDM16 suppresses MLL1r leukemia via intrinsic histone methyltransferase activity” which was published in the journal Molecular Cell on April 27th, 2016. Dr. Bo Zhou is the first author. Other co-authors from the Department include Shirley Y. Lee, Yuqing Sun, and Rajesh C. Rao. The article can be found online at:
http://www.cell.com/
Dr. Venneti named Kimmel Scholar for his cancer research efforts
Assistant Professor, Sriram Venneti, MD, PhD, was named a Kimmel Scholar by the Sidney Kimmel Foundation. The Kimmel Scholar Awards are given annually to 15 innovative research scientists and medical doctors in the U.S. who are in the early stages of their careers. Dr. Venneti will receive a $200,000 grant for his work, titled, “Metabolic regulation of epigenetics in childhood brain tumors.” Congratulations, Dr. Venneti, on being recognized as one of the country’s most promising young cancer researchers!
Congratulations to Dr. Asma Nusrat
Congratulations to Dr. Asma Nusrat, Director of Experimental Pathology on her election as Vice President of the American Society for Investigative Pathology (ASIP). Her term is effective July 1, 2016 after which she will become President elect, then President on July 1, 2018. Dr. Nusrat has been a productive member of the ASIP community for over a decade participating in many program committees and task forces. Her commitment to enhance experimental pathology and translational medicine is admirable as evidenced by her work as the program committee chair for ASIP and PISA (Pathobiology for Investigators, Students, and Academicians) conference. Please join us in congratulating her on this prestigious national leadership appointment in Experimental Pathology
Apply for the Pathology Proteomics Resource Facility Pilot Project Program
Description: The Department of Pathology invites applications from faculty with primary appointment in Pathology for proteomics related Pilot Projects that intend to use the state-of-the-art Proteomics Resource Facility (PRF) at the University of Michigan Medical School that is led by Dr. Alexey Nesvizhskii. Funds are primarily meant to help offset the cost of proteomic experiments, the results of which could potentially form the basis for or strengthen an extramural grant application. The grant is a cost share (2/3 funded by Department of Pathology and 1/3 by the investigator).
Who Can Apply: Department of Pathology Faculty
Applications will be accepted on a rolling basis and reviewed on a monthly basis. Applications received by Monday February 29, 2016 will be reviewed by March 8, 2016.
More information about this opportunity can be found by Clicking Here
Pathology Laboratory Reports New Findings in the Journal Nature
The laboratory of Dr. Gabriel Nuñez, Paul de Kruif Professor of Pathology, reported new findings in the article “NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux” which was published as an advance online publication in the journal Nature on January 27, 2016. Dr. Yuan He is the first author. Other co-authors from the Department include Dr. Melody Zeng and Dr. Dahai Yang. The article can be found online here at http://www.nature.com.
Arul M. Chinnaiyan, MD, PhD, was among the group of distinguished cancer scientists called to Washington DC for advice
Jeff Hodgin winner of prestigious Gloria Gallo Research Award
Last week we were thrilled to learn that Jeff Hodgin is this year’s recipient of the Gloria Gallo Research Award, an award given by the Renal Pathology Society in honor of one of its founding members for the most impactful research program. He received the award at the annual meeting of the American Society of Nephrology. In the words of Matthias Kretzler, Warner-Lambert/Parke-Davis Professor of Medicine and Jeff’s scientific mentor . . .
Undergraduate Researchers Win Awards from AIC & AAI
14th Annual Pathology Research Symposium
The 14th Annual Pathology Research Symposium, organized and hosted by the Pathology Graduate Student Council, and sponsored by the Molecular and Cellular Pathology Graduate Program in the Department of Pathology at the University of Michigan will take place, Thursday, Nov. 5, 2015, from 9:30am to 4:15pm at the Palmer Commons Auditorium.
Distinguished Faculty Lectureship Award in Biomedical Research goes to Eric Fearon
The highest honor bestowed by the University of Michigan Medical School was presented to Eric Fearon, MD, PhD as he received the Distinguished Faculty Lectureship Award. Given to an extraordinary leader in research whose scientific contributions are pivotal in advancing their field of scientific knowledge, this award also recognizes excellence in teaching, mentoring and service to the institution at large.
Click Here for more info on the event.
Molecules and Machines
The 2nd Annual Protein Folding Diseases Initiative Symposium, “Molecules and Machines”, was held on Friday, September 18, 2015, at the A. Alfred Taubman Biomedical Science Research Building.
The University of Michigan Protein Folding Diseases Initiative (PFDI), lead by Drs. Andrew Lieberman and Henry Paulson, seeks to connect the diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”
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