News Archive

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Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers

January 4, 2022 / Mctp

A chromatin degrader stops transcription factors from driving cancer, which may serve as a potential treatment approach for over 90% of prostate cancers.

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Inside the COVID Pandemic: A Laboratory Perspective

November 29, 2021 / Insidepath

The SARS-CoV-2 virus brought lab testing to the headlines. Learn how Michigan Medicine Pathology responded to this unprecedented challenge.

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TRIM63 - What is it? (Hint: Not a weight-loss product)

August 9, 2021 / Cancer

Dr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology  [...]

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Researchers Uncover Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer

August 3, 2021 / Blog

Findings offer clues to why some types of renal cell carcinoma respond to immunotherapy while others do not — it’s a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

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Analysis Reveals How Kidney Cancer Develops and Responds to Treatment

June 10, 2021 / Mctp

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]

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Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer

May 12, 2021 / Mctp

Stopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.

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Arul Chinnaiyan, MD, PhD, Recognized for Outstanding Research

May 7, 2021 / Award

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “Exploring Precision Oncology: from Gene Fusions to Related Genetic Drivers“ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021 [...]

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Arul Chinnaiyan, MD, PhD Recognized for Outstanding Research

May 3, 2021 / Mctp

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “ “ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021.

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Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

April 14, 2021 / Cancer Research

MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.

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New Assay For Early Detection of Aggressive Prostate Cancers Developed

April 13, 2021 / Cancer Research

A new study, led by U-M graduate in molecular and cellular pathology Dr. Andi Cani, was just published in European Urology Oncology. The publication focuses on the development of a whole-urine, multiplexed, next-generation RNA-sequencing assay that is used for the early detection of aggressive forms of prostate cancer [...]

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"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra

March 9, 2021 / Careers In Pathology

Dr. Mehra discusses his career path and how he arrived at Michigan Medicine in our latest Careers in Pathology video.

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Stressed Cellular Protein HOPS Into Action

February 16, 2021 / Experimental Pathology

Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]

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Research from Dr. Udager Published in European Urology

February 1, 2021 / Cancer

A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]

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Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead

December 22, 2020 / Cancer Research

Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]

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Research Regarding Microcystic Adnexal Carcinomas Published

June 11, 2020 / Cancer Research

The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

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U-M Researchers Home in on Key Player in Pancreatic Cancer Development

June 4, 2020 / Mctp

The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

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Research Regarding Invasive Squamous Cell Carcinoma Published

May 29, 2020 / Experimental Pathology

The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

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Research about Renal Cell Carcinoma in Young Adults Published

May 22, 2020 / Publications

The research was just published in Histopathology and features prominent contributions from our faculty.

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Arul Chinnaiyan, MD, PhD, elected to the National Academy of Science

April 28, 2020 / Award

Congratulations to Arul M. Chinnaiyan, MD, PhD, on his election to the National Academy of Science!  Chinnaiyan is an investigator, Howard Hughes Medical Institute; and S.P. Hicks Endowed Professor of Pathology, American Cancer Society Research Professor, and director, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor [...]

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Marcin Cieslik Receives Award from Bristol-Myers Squibb

March 11, 2020 / Award

Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.

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Engaging Our Future

November 8, 2019 / Outreach

Department faculty outreach to high school students to educate about careers in medicine and research.

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Faculty and Trainees Work to Understand Therapy-Resistant Malignancies

October 30, 2019 / Faculty

Two Michigan Medicine Fellows, Caroline Simon, MD, and Stephanie Skala, MD, (who recently joined the Department of Pathology as faculty), joined colleagues from the Michigan Center for Translational Pathology, in a research study published in Diagnostic Pathology dated October 21, 2019 [...]

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U-M Compounds Show Promise in a Lab Model of Advanced Prostate Cancer

May 14, 2019 / Experimental Pathology

A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.

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Witnessing the dance of RNAs around droplets of cellular degradation machinery

April 3, 2019 / Experimental Pathology

If a picture's worth a thousand words, a video is perhaps worth much more.

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Medicine, Humility, Respect, and Beyond

November 8, 2018 / Newsletter

Rohit Mehra, MD—faculty perspective on the need to understand why a patient’s cancer would not respond to treatment.

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Team Led by Dr. Rohit Mehra discovers New Diagnostic Biomarker for Kidney Cancer

October 11, 2018 / Experimental Pathology

A recent collaborative study out of the Michigan Center for Translational Pathology (MCTP) has led to new insight into kidney cancer. The resulting paper, VSTM2A Overexpression is a Sensitive and Specific Biomarker for [...]

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