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TRIM63 - What is it? (Hint: Not a weight-loss product)

Dr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology  [...]

August 9 2021

Researchers Uncover Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer

Findings offer clues to why some types of renal cell carcinoma respond to immunotherapy while others do not — it’s a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

August 3 2021

Analysis Reveals How Kidney Cancer Develops and Responds to Treatment

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]

June 10 2021

Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer

Stopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.

May 12 2021

Arul Chinnaiyan, MD, PhD, Recognized for Outstanding Research

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “Exploring Precision Oncology: from Gene Fusions to Related Genetic Drivers“ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021 [...]

May 7 2021

Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.

April 14 2021
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"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra

Dr. Mehra discusses his career path and how he arrived at Michigan Medicine in our latest Careers in Pathology video.

March 9 2021

Stressed Cellular Protein HOPS Into Action

Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]

February 16 2021

Research from Dr. Udager Published in European Urology

A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]

February 1 2021

Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead

Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]

December 22 2020

Research Regarding Microcystic Adnexal Carcinomas Published

The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

June 11 2020

U-M Researchers Home in on Key Player in Pancreatic Cancer Development

The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

June 4 2020

Research Regarding Invasive Squamous Cell Carcinoma Published

The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

May 29 2020

Research about Renal Cell Carcinoma in Young Adults Published

The research was just published in Histopathology and features prominent contributions from our faculty.

May 22 2020

Arul Chinnaiyan, MD, PhD, elected to the National Academy of Science

Congratulations to Arul M. Chinnaiyan, MD, PhD, on his election to the National Academy of Science!  Chinnaiyan is an investigator, Howard Hughes Medical Institute; and S.P. Hicks Endowed Professor of Pathology, American Cancer Society Research Professor, and director, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor [...]

April 28 2020

Marcin Cieslik Receives Award from Bristol-Myers Squibb

Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.

March 11 2020
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Engaging Our Future

Department faculty outreach to high school students to educate about careers in medicine and research.

November 8 2019

Faculty and Trainees Work to Understand Therapy-Resistant Malignancies

Two Michigan Medicine Fellows, Caroline Simon, MD, and Stephanie Skala, MD, (who recently joined the Department of Pathology as faculty), joined colleagues from the Michigan Center for Translational Pathology, in a research study published in Diagnostic Pathology dated October 21, 2019 [...]

October 30 2019
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U-M Compounds Show Promise in a Lab Model of Advanced Prostate Cancer

A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.

May 14 2019
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Witnessing the dance of RNAs around droplets of cellular degradation machinery

If a picture's worth a thousand words, a video is perhaps worth much more.

April 3 2019
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Medicine, Humility, Respect, and Beyond

Rohit Mehra, MD—faculty perspective on the need to understand why a patient’s cancer would not respond to treatment.

November 8 2018

Team Led by Dr. Rohit Mehra discovers New Diagnostic Biomarker for Kidney Cancer

A recent collaborative study out of the Michigan Center for Translational Pathology (MCTP) has led to new insight into kidney cancer. The resulting paper, VSTM2A Overexpression is a Sensitive and Specific Biomarker for [...]

October 11 2018