Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.
New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]
The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.
The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.
A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.
Modern Pathology recently published a multi-institutional study led by pathology faculty Dr. Rohit Mehra; other participating centers included The Cleveland Clinic, Emory School of Medicine and Memorial Sloan Kettering Cancer Center. Third year Pathology resident at Michigan Medicine, Alex Taylor, MD, was the first author with other major contributions by Drs. Noah Brown and May Chan. [...]
Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]
All faculty who serve as the Principal Investigator or one of the key personnel on an NIH award or pending proposal are required to review their new guidance and address the two parts below, as appropriate, by January 20, 2020 [...]
The National Cancer Institute’s (NCI) Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding PhD and other Research Doctoral candidates who complete their dissertation research training (F99 phase) and transition in a timely manner to mentored, cancer-focused postdoctoral career development research positions (K00 phase). [...]
Carrie-Anne Malinczak, PhD successfully defended her thesis entitled “Long-Term Immune System Alterations Following Early-Life RSV Infection” on October 21, 2019. Respiratory syncytial virus (RSV), a ubiquitous human pathogen, infects nearly all children by age two. Severe RSV bronchiolitis in infancy is strongly correlated with the development of recurrent wheezing later in childhood [...]
Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]
In collaboration with Drs. Luke Nayak and Arjun Sondhi, Dr. Maria Westerhoff published a report in Gastroenterology titled, "A Rare Complication of a Rare Disease" documents a case of erythropoietic protoporphyria, a rare condition that can affect the liver [...]
Congratulations to Jolanta Gembecka, PhD, who is one of fourteen in the inaugural class of Rogel Scholars! As part of the commitment from Richard and Susan Rogel, researchers will have the opportunity and freedom to pursue new directions in their work. Dr. Grembecka's research focus is developing [...]
Researchers identify a lncRNA that provides insight into a key driver of prostate cancer — and a potential target for future therapy.