News Archive

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Research from INHERET Published in JNCCN

January 18, 2022 / Publications

Research from INHERET was just published in the Journal of the National Comprehensive Cancer Network (JNCCN). Learn more about this study, which analyzes the implementation of InheRET's online tool that provides information about family history as it relates to cancer risks [...]

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Research Study Published in European Urology's Open Science

January 5, 2022 / Publications

 A multi-institutional study led by Drs. Alex Taylor, Noah Brown and Rohit Mehra from the Department of Pathology was just published in European Urology's Open Science. Learn more about the resarch, which focuses on how TERT promoter mutations were characterized in urinary tract lesions, which may be considered as precursors to neoplasia at this site [...]

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Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers

January 4, 2022 / Video

A chromatin degrader stops transcription factors from driving cancer, which may serve as a potential treatment approach for over 90% of prostate cancers.

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The Yin and the Yang of Research in the COVID Era

December 20, 2021 / Newsletter

As COVID closed down research labs, researchers shifted focus.

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Study Finds that Microbiome Colonization During Infancy is Critical for Modulating Immunity Later in Life

October 29, 2021 / Experimental Pathology

A study related to the maternal gut microbiome and how it regulates immunity to respiratory syncytial virus (RSV) infections in offspring was recently published in the Journal of Experimental Medicine. Clinical experts from the Department of Pathology including Drs. Wendy Fonseca, Nicholas Lukacs, and Catherine Ptaschinski were responsible for carrying out this study [...]

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The Link Between Dysplastic Squamous Cells and Merkel Cell Carcinoma (MCC)

October 15, 2021 / Clinical Pathology

Research pertaining to Merkel cell carcinoma (MCC) and cutaneous neuroendocrine carcinomas was just published in the latest edition of Modern Pathology. Led by the team of Drs. Paul Harms, May Chan, Aaron Udager, Rajiv Patel, and more [...]

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MCP Student Siva Kumar Natarajan Awarded Mistletoe Research Fellowship

August 25, 2021 / Award

Congratulations to Molecular and Cellular Pathology Graduate Student Siva Kumar Natarajan on being awarded the Mistletoe Research Fellowship (MRF).  Established in 2018, the Momental Foundation awards 20 MRF positions to exceptional postdoctoral fellows and advanced PhD candidates from the United States, Japan, and Singapore.

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Researchers Develop First Inhibitors Against Key Epigenetic Complex Involved in Cancer

June 21, 2021 / Research

Activity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach. Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia [...]

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Research Published in Urologic Oncology's ScienceDirect

June 10, 2021 / Clinical Pathology

Research by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]

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Coronavirus (COVID-19) Research Published in Archives of Pathology and Laboratory Medicine

May 18, 2021 / Anatomic Pathology

Research from the Department of Pathology was just published in the Archives of Pathology and Laboratory Medicine. Learn more about this publication, which highlights GI samples from COVID-19 patients, led by Dr. Maria Westerhoff [...]

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Researchers Develop First-in-Class Inhibitors Against Key Leukemia Protein

May 17, 2021 / Michigan Health Blog

A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]

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Research from Lombard Lab Published in Journal of Clinical Investigation

May 12, 2021 / Publications

Research from the Department's Lombard Lab was just published in the Journal of Clinical Investigation. The study, which focuses on how the deacylase SIRT5 compound supports melanoma viability by influencing chromatin dynamics, was led by Dr. Lombard [...]

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Broadening the Scope: A Qualitative Study of Pathologists’ Attitudes Toward Patient-Pathologist Interactions

May 5, 2021 / Quality And Health Improvement

Learn more about pathologists' attitudes toward patient interactions in this new publication, led by Dr. Cathryn Lapedis.

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Research by Dr. Cho Published in AACR's "Cancer Research"

April 19, 2021 / Clinical Pathology

A new publication from the Department of Pathology, led by Dr. Kathleen Cho, was just published in the American Association for Cancer Research's flagship journal. highlights how altering the microbiome within a mouse model of oviductal high-grade serious carcinoma can inhibit tumorigeneis [...]

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New Assay For Early Detection of Aggressive Prostate Cancers Developed

April 13, 2021 / Clinical Pathology

A new study, led by U-M graduate in molecular and cellular pathology Dr. Andi Cani, was just published in European Urology Oncology. The publication focuses on the development of a whole-urine, multiplexed, next-generation RNA-sequencing assay that is used for the early detection of aggressive forms of prostate cancer [...]

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Department of Pathology Shines at 2021 Virtual USCAP Meeting

March 24, 2021 / Conferences

The Department of Pathology was well represented at the 110th Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), held March 13-18, 2021. This year's event was reconstructed into a fully virtual format in response to the COVID-19 pandemic, with participants able to tune in and contribute from all over the world. Several of our faculty and trainees were featured at this year's conference. Let's take a moment to recap some key highlights from #USCAP2021.

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Two Proteins Critical for Kidney Function

March 24, 2021 / Michigan Health Blog

Research by Drs. Ann Laszczyk and the Department of Pathology's Dr. Gregory Dressler was just published in the Journal of the American Society of Nephrology. The study focuses on PAX2 proteins and their effects on kidney function and development.

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Stressed Cellular Protein HOPS Into Action

February 16, 2021 / Experimental Pathology

Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]

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Role of BATF in the Development of Innate Lymphoid Cells Elucidated

February 10, 2021 / Publications

A series of sophisticated processes are required in the development of innate lymphoid cells (ILC) for them to reach maturity. The Kim laboratory discovered that basic leucine zipper ATF-like transcription factor (Batf) regulates the production of ILC progenitors in the bone marrow as well as the maintenance of ILCs in the periphery. These cells are strategically distributed in peripheral tissues to provide important innate immunity to fight pathogens such as pathogenic viruses and bacteria.

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The multi-faceted role of the SUV family of H3K9 methyltransferases

February 8, 2021 / Clinical Pathology

A new study from Drs. Andrew Muntean and Nirmalya Saha of the Department of Pathology's Muntean Lab was just published in Biochim et Biophysica (BBA) Reviews on Cancer. The research project sheds light on the multi-faceted role of the SUV family of H3K9 methyltransferases in carcinogenesis and within cancer progression.

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Research from Dr. Udager Published in European Urology

February 1, 2021 / Publications

A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]

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Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes

January 5, 2021 / Experimental Pathology

A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes. 

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Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead

December 22, 2020 / Michigan Health Blog

Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]

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Research Led by Drs. Cierpicki and Grembecka Published in "Blood"

December 2, 2020 / Clinical Pathology

A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]

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Research Led by Dr. Udager Published in Modern Pathology

November 19, 2020 / Clinical Pathology

New research by the Department of Pathology was recently published in Modern Pathology. The study, led by Drs. Aaron Udager, Noah Brown, Bryan Betz, Jonathan McHugh and Scott Tomlins, focuses on how TP53 mutations and CDKN2A mutations and deletions are highly recurrent molecular alterations within malignant progression of sinonasal papilomas [...]

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Dr. Celina Kleer Wins ASIP 2020 Outstanding Investigator Award

November 12, 2020 / Experimental Pathology

Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]

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Study Regarding Inhibition of Class I PI3K Published in Journal of Cell Biology

October 30, 2020 / Publications

Research by the Department of Pathology's Drs. Richard Miller and Joseph Endicott was just published in the Journal of Cell Biology. The study focuses on the inhibition of class I PI3K and how it enhances chaperone-mediated autophagy (CMA) [...]

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Host-Microbiota Interactions in Health and Disease: Gabriel Nunez, MD

October 20, 2020 / Events

12:00 pm EST

Join #UMichPath and the University of Pennsylvania's Perelman School of Medicine for a virtual event with department faculty Dr. Gabriel Nuñez, who will be hosting a discussion related to host-microbiota interactions in modern health and disease.

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Michigan Medicine Highlights Phlebotomy Research on Podcast

October 20, 2020 / Quality And Health Improvement

Experts from the Department of Pathology's Phlebotomy Team were featured on Michigan Medicine's "The Wrap" podcast. The podcast focuses on the department's Poke Plan Program at C.S. Mott Children's Hospital, an initiative that helps to alleviate pain and fear among children during the blood draw process [...]

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Bad Bacteria Make Their Own Food to Colonize the Gut

October 16, 2020 / Experimental Pathology

Diarrhea can be the unfortunate but short-lived side effect of bad takeout food, yet it is also a leading cause of death in children under five globally. Scientists continue to investigate how illness-causing bacteria gain a foothold within the digestive tract when they are usually held in check by the protective bacteria collectively known as the gut microbiome [...]

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Understanding Breast Cancer: My Journey as a Physician-Scientist: Celina Kleer, MD

October 9, 2020 / Events

10:00 am EST

Join us for a virtual event featuring the Department of Pathology's Dr. Celina Kleer, who will host a discussion related to her experiences in understanding breast cancer and her journey as a physician-scientist.

Register Now

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ASIP Rous-Whipple Award Lecture: Arul Chinnaiyan, MD, PhD

October 1, 2020 / Events

11:30 am EST

Join us for a virtual event featuring the Department of Pathology's Dr. Arul Chinnaiyan, who will give the 2020 American Society for Investigative Pathology (ASIP)'s Rous-Whipple Award Lecture. 

Register Here

 

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Research By Dr. Hristov Published in Journal of Cutaneous Pathology

October 1, 2020 / Publications

New research from the Department of Pathology and Dr. Alexandra Hristov was just published in the Journal of Cutaneous Pathology. The study focuses on the kappa and lambda immunohistochemistry in situ hybridization of atypical cutaneous lymphoid infiltrates. 

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Scientists Develop First Drug-Like Compounds to Inhibit Elusive Cancer-Linked Enzymes

September 2, 2020 / Michigan Health Blog

Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.

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Research Surrounding H3K27M-mutant diffuse midline glioma in COVID-19 Published

July 7, 2020 / Experimental Pathology

New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]

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Research Surrounding miR-181a Published

June 25, 2020 / Experimental Pathology

Research from Dr. Analisa Difeo was just published in Nature Communications. The study focuses on miR-181a and how it initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling [...]

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Forensic Research Regarding COVID-19 Published

June 18, 2020 / Experimental Pathology

The publication takes an in-depth examination of diffuse alveolar damage (DAD) caused by COVID-19 and how it is morphologically indistinguishable from other causes of DAD.

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U-M Researchers Home in on Key Player in Pancreatic Cancer Development

June 4, 2020 / Experimental Pathology

The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

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Research Regarding Invasive Squamous Cell Carcinoma Published

May 29, 2020 / Experimental Pathology

The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

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Diagnostic Biomarkers Uncovered for Rare Kidney Cancer

April 21, 2020 / Experimental Pathology

Researchers have uncovered the gene signature for ChRCC.

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Department Co-Hosts 2020 Mucosal Immunology Symposium

March 13, 2020 / Conferences

The event showcased experiemental pathology research.

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Department Hosts 11th Annual CHAMP Research Symposium

February 17, 2020 / Conferences

Event showcases clinical and translational research.

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Anti-Leukemia Compound Induces Complete Remission in Mouse Models

February 3, 2020 / Experimental Pathology

A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.

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Results of Michigan-Led Study Published in Modern Pathology

January 23, 2020 / Publications

Modern Pathology recently published a multi-institutional study led by pathology faculty Dr. Rohit Mehra; other participating centers included The Cleveland Clinic, Emory School of Medicine and Memorial Sloan Kettering Cancer Center. Third year Pathology resident at Michigan Medicine, Alex Taylor, MD, was the first author with other major contributions by Drs. Noah Brown and May Chan. [...]

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A Simple Twist of Cell Fate

January 15, 2020 / Experimental Pathology

U-M researchers are shedding new light with exciting implications for research and health.

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Dr. Chan Chung Receives Two Grants to Study Brain Cancers

January 9, 2020 / Experimental Pathology
 

Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]

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Updated NIH Policy Statement Emphasizes "Other Support" Reporting

December 20, 2019 / Announcement

All faculty who serve as the Principal Investigator or one of the key personnel on an NIH award or pending proposal are required to review their new guidance and address the two parts below, as appropriate, by January 20, 2020 [...]

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R01 Granted to Jolanta Grembecka, PhD

December 20, 2019 / Award

We are thrilled to announce that Jolanta Grembecka, PhD, an Associate Professor in Pathology, has been granted an R01 for her research “Development of ASH1L inhibitors for acute leukemia.” [...]

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Abhijit Parolia is Awarded The NCI Predoctoral to Postdoctoral Fellow Transition Award

December 2, 2019 / Announcement
 

The National Cancer Institute’s (NCI) Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding PhD and other Research Doctoral candidates who complete their dissertation research training (F99 phase) and transition in a timely manner to mentored, cancer-focused postdoctoral career development research positions (K00 phase). [...]

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Results from the Andrew P. Lieberman Lab are Published

November 20, 2019 / Announcement

Mark Schultz, PhD, and Andrew Lieberman MD, PhD, have published “Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases” in BMC Medicine. [...]

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From Carrie-Anne to Dr. Malinczak

November 12, 2019 / Phd Program

Carrie-Anne Malinczak, PhD successfully defended her thesis entitled “Long-Term Immune System Alterations Following Early-Life RSV Infection” on October 21, 2019. Respiratory syncytial virus (RSV), a ubiquitous human pathogen, infects nearly all children by age two. Severe RSV bronchiolitis in infancy is strongly correlated with the development of recurrent wheezing later in childhood [...]

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Engaging Our Future

November 8, 2019 / Publications

Department faculty outreach to high school students to educate about careers in medicine and research.

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Dr. Surinder Kumar Receives The Pablove Foundation Childhood Cancer Research Grant

September 18, 2019 / Experimental Pathology

Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]

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Dr. Maria Westerhoff Publishes in Gastroenterology

August 20, 2019 / Publications

In collaboration with Drs. Luke Nayak and Arjun Sondhi, Dr. Maria Westerhoff published a report in Gastroenterology titled, "A Rare Complication of a Rare Disease" documents a case of erythropoietic protoporphyria, a rare condition that can affect the liver [...]

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U-M Compounds Show Promise in a Lab Model of Advanced Prostate Cancer

May 14, 2019 / Experimental Pathology

A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.

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Jolanta Grembecka, PhD, Among 14 Inaugural Rogel Scholars

May 14, 2019 / Experimental Pathology

Congratulations to Jolanta Gembecka, PhD, who is one of fourteen in the inaugural class of Rogel Scholars!  As part of the commitment from Richard and Susan Rogel, researchers will have the opportunity and freedom to pursue new directions in their work. Dr. Grembecka's research focus is developing [...]

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Witnessing the dance of RNAs around droplets of cellular degradation machinery

April 3, 2019 / Experimental Pathology

If a picture's worth a thousand words, a video is perhaps worth much more.

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Creating Hope

February 18, 2019 / Experimental Pathology

Mark Schultz, PhD strives to create therapeutics for Niemann-Pick disease.

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Circular RNA Holds Promise as Cancer Biomarker

February 7, 2019 / Experimental Pathology

Unique structure of circRNA makes it an ideal candidate for biomarkers – and it can be detected in blood or urine.

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Work from the Dou and Dressler Labs highlighted in Cancer Cell

October 9, 2018 / Research

The laboratories of Dr. Yali Dou and Dr. Gregory Dressler have collaborated with colleagues at the National Institutes of Health, the Sloan Kettering Cancer Center, the Dana Farber Cancer Institute, and Indiana University to publish HOXA9 Reprograms the [...]

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Genome's Dark Matter Sheds Light on Prostate Cancer Challenge

June 1, 2018 / Experimental Pathology

Researchers identify a lncRNA that provides insight into a key driver of prostate cancer — and a potential target for future therapy.

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