Pathology News

Pathology Laboratory Reports Structure of BMI1-PHC2 complex

By Tomasz Cierpicki | 10 November

The laboratory of Dr. Tomasz Cierpicki has determined the structure of BMI1 protein in complex with PHC2 and characterized its role in regulation of the architecture and activity of the PRC1. The article "BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization" has been published in Nature Communications journal on Nov 9th, 2016 and is available online. Co-first authors are Felicia Gray, Hyo-Je Cho and Shirish Shukla, and this is a collaborative study with Dr. Grembecka and Dr. Lawlor from the Department of Pathology.

 

 
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