Meet the Lab

Asma Nusrat, MD

F. Peyton Rous Professor, Mucosal Inflammation and Epithelial Pathobiology; Director of Experimental Pathology
anusrat [at] med.umich.edu

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Dr. Nusrat’s research has focused on investigating mechanisms that orchestrate epithelial barrier regulation, mucosal homeostasis and repair in inflammatory disorders. Epithelial barrier function is achieved by a series of intercellular junctions that include an apical tight junction, subjacent adherens junction and desmosomes. We are exploring molecular mechanisms by which inflammatory mediators alter intercellular junction protein complexes and epithelial barrier function. In addition, ongoing studies are elucidating the influence of inflammatory and pro-resolution mediator signaling on epithelial homeostasis, wound repair and restoration of barrier function. Signaling down-stream of G-protein coupled receptors including formyl peptide receptors in response to protein and lipid pro-resolution ligands that coordinate intestinal mucosal wound repair are being investigated.

Education

MD, University of Punjab (1982)
Residency, Brigham and Women’s Hospital, Boston, MA (1987-1989)
Postdoctoral Fellow, Brigham and Women’s Hospital, Boston, MA (1989-1992)

Administrative Appointments

Instructor of Pathology, Harvard Medical School, Boston, MA (1992-1996)
Staff Pathologist, Brigham and Women’s Hospital, Boston, MA (1992-1997)
Staff Consultant, Gastrointestinal Pathology, Children’s Hospital, Boston, MA (1993-1996)
Assistant Professor of Pathology, Harvard Medical School, Boston, MA (1996-1997)
Assistant Professor of Pathology, Emory University, Atlanta, GA (1997-2003)
Associate Professor of Pathology (Tenure), Emory University, Atlanta, GA (2003-2007)
Professor of Pathology and Cell Biology (Tenure), Emory University, Atlanta, GA (2007-2015)
AS Warthin Professor (Tenure) and Director of Experimental Pathology, University of Michigan (2015-present)

Funding Sources

P.I., NIH, “Intestinal epithelial tight junction structure function”, RO1-DK59888
P.I., NIH, “Intestinal mucosal wound resealing in IBD”, RO1-DK055679
Co.I., NIH “Forml peptide receptors as mediators of intestinal mucosal homeostasis”, RO1-DK089763
Co-P.I., DoD, “CLMP-mediated regulation of intestinal homeostasis in IBD”, PRMP

Charles A. Parkos, MD, PhD

Carl V. Weller Professor and Chair, Mucosal Inflammation and Epithelial Pathobiology
cparkos [at] med.umich.edu

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Dr. Parkos’ research interests focus on basic mechanisms of epithelial-immune cell interactions and the impact on mucosal homeostasis. Using in-vitro and in-vivo approaches, the lab is studying the molecular basis of leukocyte migration across mucosal epithelia as well as the impact of inflammation on epithelial barrier function as observed in pathologic conditions such as ulcerative colitis and Crohn’s disease. Dr. Parkos and his team have elucidated the roles of many epithelial and neutrophil proteins in regulating leukocyte trafficking across the intestinal mucosa that include adhesion/signaling molecules such as CD11b/CD18, CD47, SIRPalpha, junctional adhesion molecules (JAMs), and cell surface glycans. Recent studies by the group have provided important insights into fundamental mechanisms of how these receptors regulate mucosal homeostasis during health and disease. Current projects in the laboratory are using complementary in-vitro and in-vivo approaches to examine the role of JAM family members in the regulation of epithelial barrier and leukocyte migration, characterizing the signaling events that occur between leukocytes and epithelial cells that serve to control leukocyte transmigration and epithelial permeability, and elucidating the structural basis of protein interactions that regulate these responses.

Education

BA, University of California - San Diego (1979)
PhD, University of California - San Diego/Scripps Clinic and Research Foundation (1987)
MD, University of California - San Diego (1987)
Pathology Residency, Brigham and Women’s Hospital, Boston, MA 1988-1991

Administrative Appointments

Assistant Professor, Department of Pathology, Harvard Medical School, Boston, MA (1992-1997)
Associate Professor, Department of Pathology, Emory University School of Medicine, Atlanta, GA (1997-2003)
Professor, Department of Pathology, Emory University School of Medicine, Atlanta, GA (2003-2014)
Director, Emory University MD/PhD training Program (2007-2014)
Vice Chair, Department of Pathology, Emory University School of Medicine, Atlanta, GA (2008-2014)
Carl V. Weller Professor and Chair, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (2014-present)

Funding Sources

P.I., NIH, “Neutrophil interactions with intestinal epithelium,” RO1-DK72564.
P.I., NIH, "Structure function studies on intestinal epithelial JAM" R01-DK61379.
P.I., NIH, "Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration" R01-DK079392.
Co-P.I., DoD, “CLMP-mediated regulation of intestinal homeostasis in IBD”, PRMP

Jennifer Brazil, PhD

Research Assistant Professor
brazilj [at] med.umich.edu

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Dr. Brazil has a PhD in Medicine and Molecular Science, having completed a doctoral dissertation at the Conway Institute of Biomolecular Medicine in University College Dublin, Ireland studying the dynamic neutrophilic response to inflammatory stimuli. In 2008, she joined the lab of Dr. Nancy Louis as a Postdoctoral Fellow in the pathobiology group at the Department of Pediatrics at Emory University in Atlanta, Georgia. During this initial postdoctoral period, Dr. Brazil characterized the GM35 antibody and its attenuation of neutrophil transepithelial migration through binding to the carbohydrate structure sialyl Lewis A on epithelial CD44v6 (see publications link below). Because of the relevance of her work to inflammation associated mucosal tissue damage, in 2012, Dr. Brazil was awarded a research fellowship award from the Crohn’s and Colitis Foundation of America (CCFA) and in 2014 she was successful in her application for a career development award from the same funding agency. In 2014, Dr. Brazil joined the Parkos lab in the Department of Pathology, Emory University as a Research Associate and subsequently accepted a junior faculty position as a Research Investigator in the Department of Pathology at the University of Michigan. Most recently, Dr. Brazil’s work has focused on characterizing the role of PMN expressed Lewis glycans during neutrophil transepithelial migration and during neutrophil function in inflamed intestinal mucosa.

Shuling Fan, MD

Research Lab Specialist Senior
shulingf [at] med.umich.edu

Charles Parkos
Name	Dates in the Lab	Current Position
Luca Mazzucchelli, MD	1995-1997	Professor, Institute of Pathology, Locarno, Switzerland
Leora Balsam, MD	1994-1996	Associate Professor, Cardiothoracic Surgery, NYU Langone Medical Center, New York, USA
Tony Liang	1994-1998	Associate Scientist, Unity Biotechnology, San Francisco, USA
David L. Jaye, MD	1998-2007	Assistant Professor of Pathology, Emory University, Atlanta, USA
Titus Reaves, PhD	1998-2004	Assistant Professor of Anatomy and Cell Biology, Department of Regenerative Medicine, Medical College of South Carolina, USA
Yuan Liu, PhD	1998-2004	Professor of Biology, Georgia State University, Atlanta, GA
Fred Schnell, PhD	1998-2001	Scientist, Sarepta Therapeutics, Corvallis, Oregon, USA
Heather Edens, PhD	1999-2003	Associate Scientific Director, SciMentum, Atlanta, GA
Ke Zen, PhD	2000-2005	Vice Dean of Life Sciences, Nanjing University, Nanjing China
Andrei Ivanov, PhD	2002-2007	Associate Professor, Virginia Commonwealth University, USA
Kenneth J Mandell, MD PhD	2002-2005	Chief Medical Officer, Noveome Biotherapeutics, USA
Alex Chin, PhD	2003-2008	Director, Clinical Laboratories, University of Calgary, Canada
Winston Lee, MD PhD	2004-2008	Hematopathology Fellow, Brigham and Women’s Hospital/Harvard Medical School, Boston, USA
Eric Severson, MD PhD	2005-2008	Staff Scientist and Hematopathologist, Foundation Medicine, Duram, North Carolina, USA
Rita Jen MD, MPh	2004-2007	Urology Resident, University of Michigan, Ann Arbor, USA
Dominique Weber, PhD	2005-2015	Assistant Professor of Pathology, Emory University, Atlanta, USA
Ingrid McCall, MS	2006-2009	Lab management, Emory University, Atlanta, USA
Abigail Betanzos, PhD	2006-2008	Staff scientist, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
Nancy Louis, MD	2006-2015	Neonatologist, Athens Georgia, USA
Eric Peatman, PhD	2007-2009	Associate Professor, School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Alabama, USA
Jodi Zuckerman, MD	2007	Otolaryngology, Chicago, USA
Aaron Rogers, MD	2009	Otolaryngology, Atlanta, USA
Ana Monteiro, MD PhD	2009-2014	Internal Medicine Resident, UCLA Medical Center, Los Angeles, USA
Ilke Nalbantoglu, MD	2009-2010	Assistant Professor, Washington University, St. Louis, USA
Manirath Khounlotham, PhD	2009-2012	Postdoctoral Associate, Weill Cornell Medical College, New York, USA
Timothy L. Denning, PhD	2009-2013	Associate Professor, Center for Inflammation, Immunity, & Infection, Georgia State University, Atlanta, USA
Benedicte Fournier, PhD	2009-2013	Pharmacology Paris, France
Wooki Kim, PhD	2009-2012	Assistant Professor, Kyung Hee University, Korea
Ronen Sumagin, PhD	2009-2014	Assistant Professor, Northwestern University, Chicago, USA
Caroline Weight, PhD	2010-2014	Associate Researcher, University College London, UK
Jason Matthews, PhD	2012-2014	Postdoctoral Fellow, Emory University, Atlanta, USA
Holly C. Williams, PhD	2012-2015	Postdoctoral Fellow, Emory University, Atlanta, USA
Anna Lukacher	2012-2013	Juris Doctorate Candidate, University of New Hampshire School of Law, USA
Sarah K. Wise, MD	2012-2015	Associate Professor, Otolaryngology, Emory University, Atlanta, USA

Asma Nusrat
Name	Dates in the Lab	Current Position
Shaun V Walsh, MD	1998-2001	Consultant Pathologist, Lecturer and Director of Training Program, Ninewells Hospitals and Dundee University Medical School, Scotland
Ann Hopkins, PhD	1999-2004	Senior Lecturer and Director of International Electives Program, Royal College of Surgeons in Ireland
Julie J Ha, PhD	2001-2003	Staff Scientist Walter Reed Hospital, Washington DC, USA
Matthias Breuwar, MD	2001-2003	Professor, St. Franziskus-Hospital Munster, Germany
Bridge Tong, PhD	2001-2004	Researcher, Georgia State University, USA
G Thomas Brown, MD PhD	2001-2005	Fellow, Department of Pathology, National Institutes of Health, Washington, USA
Brian Babbin, MD	2002-2005	Medical Director, BioVantra LLC, Florida, USA
Markus Utech, MD	2003-2005	Surgery, Munster, Germany
Zili Wang, PhD	2004-2006	Instructor, Emory University, USA
Elena V Vassilieva PhD	2004-2007	Research Associate, Emory University, USA
Michael Laukoeter, MD	2005-2007	Professor, Munster University, Germany
Stanislav N. Samarin PhD	2004-2009	Strategy and Innovation in Healthcare and Biotechnology, St. Louis, USA
Neal Beeman, PhD	2008-2010	Research Scientist, University of Washington, Department of Bioengineering, Atlanta, USA
Porfirio D. Nava, PhD	2006-2012	Professor, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
Keli Kolegraff, MD PhD	2007-2012	Plastic Surgery Resident, Johns Hopkins Hospital, Baltimore, USA
Christopher Capaldo, PhD	2011-2015	Instructor, Cell Biology, Emory University, Atlanta, USA
Stefan Koch, PhD	2007-2011	Faculty, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
Giovanna Leoni, PhD	2009-2014	Research Scientist, Ludwig-Maximilians-University, Munich, Germany
Robert Rankin, PhD	2009-2014	Postdoctoral Fellow, Keck School of Medicine USC, USA
Kun Jiang, MD PhD	2012-2014	Assistant Professor, Pathology, Moffitt Cancer Center, Florida, USA
Attila E Farkas, PhD	2010-2015	Biological Research Center, Hungarian Academy of Sciences, Szeged
Ryuta Kamekura, MD	2011-2014	Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University, Japan
Ross Hamilton, PhD	2011-2012	Senior Research Scientist at Bionomics Ltd, Adelaide, Australia
Molly McLaughlin	2009-2010	Masters student, Colorado State University, USA
Hikaru Nishio, PhD	2013-2015	Business Strategy and Planning, Aminoscience Division, Ajinomoto Company, Tokyo, Japan.
Benjamin H. Hinrichs MD	2014-2015	Instructor, Pathology, Emory University, Atlanta, USA

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Parkos & Nusrat Labs

Meet the Lab

Asma Nusrat, MD

Charles A. Parkos, MD, PhD

Jennifer Brazil, PhD

Shuling Fan, MD

Vicky Garcia-Hernandez, PhD

Miguel Quiros, PhD

Arturo Raya-Sandino, PhD

Stefan Stoll, PhD

Jael Miranda-Guzman, PhD

Armando Montoya-Garcia, PhD

Sandhya Padmanabhan, PhD

Saranyaraajan Varadarajan, PhD

Zach Wilson, PhD

Kristen Lozada-Soto

Rodolfo Ismael Cabrera Silva

Yelitzza Aguilar, BS

Dylan Fink

Veronica Azcutia-Criado, PhD

Jenna Brokaw

Mingli Feng

Darius Feier

Sven Flemming, MD

Mizuho Hasegawa, PhD

Shusaku Hayashi, PhD

Roland Hilgarth, PhD

Justin Keeney

Matthias Kelm, MD

Dennis Kusters, PhD

Pam Lincoln

Anny-Claude Luissint, PhD

Renae Lyons

Meenal Mhaskar

Chithra K. Muraleedharan

Patrick O’Brien

Monique N. O’Leary, PhD

Benjamin Portelli

Michelle Reed, PhD

Dorothée Siuda, MD

Sydney Smith

Sean Watson

Mark Yulis

2014

INSIDE PATHOLOGY