News Archive

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Cytomorphology and IHC helps diagnose transformed metastatic prostate cancer

October 27, 2022 / Experimental Pathology

A research team from the Michigan Center for Translational Pathology undertook a study to illustrate how careful assessment of cytologic and biomarker features may provide physicians with information on Metastatic Prostatic Cancer (MCP) patients’ prognosis and the best therapies to consider [...]

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A new cooperation between EZH2 and p38 proteins enhances metastasis in triple negative breast cancer

August 17, 2022 / Experimental Pathology

The Celina Kleer lab at the University of Michigan Department of Pathology and Rogel Cancer Center has found a new mechanism that fuels metastasis in triple negative breast cancers. In their new study they show that EZH2, a master regulator of cell type identity, known to function through methylation of histones, has a new, unexpected function in aggressive breast cancers [...]

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Dr. Sriram Venneti named Scientific Research Director

July 1, 2022 / Announcement

Effective July 1, 2022, Dr. Sriram Venneti, Professor of Pathology, was appointed as Scientific Research Director and Dr. Carl Koschmann, Assistant Professor of Pediatrics, was appointed as Clinical Research Director for the Chad Carr Pediatric Brain Tumor Center (CC-PBTC).

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Congratulations to Dr. Jolanta Grembecka on being named the inaugural Richard and Susan Rogel Professor in Cancer Therapeutics

June 27, 2022 / Announcement

We recognize Dr. Jolanta Grembecka on being named the inaugural Richard and Susan Rogel Professor of Cancer Therapeutics. An induction ceremony will be held later this year. Please join us in congratulating her on this honor!

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Qualitative Image Analysis study shows excellent results

June 9, 2022 / Anatomic Pathology

A landmark study into quantitative image analysis in ER, PgR, and HER2 in invasive breast carcinoma was recently published in the American Journal of Clinical Pathology. Dr. Mustafa Yousif, Assistant Professor of Breast Pathology and Informatics, and colleagues conducted a retrospective study of 1,367 invasive breast carcinomas of all histopathology subtypes, for which ER, PgR, and HER2 were analyzed by manual scoring [...]

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Fun in the Sun...and Skin Cancer Risk

June 3, 2022 / Anatomic Pathology

What is skin cancer and how can you prevent it?

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Using Artificial Intelligence to predict ERG Gene Fusion in Prostate Cancer

May 10, 2022 / Experimental Pathology

The role of artificial intelligence (AI) in healthcare continues to expand. In a recent issue of BMC Cancer, Dr. Vipulkumar Dadhania (first author) and colleagues published a result of their study Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer. The expert team from the Michigan Center for Translational Pathology developed a deep-learning-based model to predict ERG genomic rearrangements in prostatic adenocarcinomas using only H&E-stained digital slides [...]

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Parolia Selected For Harold Weintraub Graduate Student Award

March 1, 2022 / Experimental Pathology

Please join us in congratulating Dr. Abhijit Parolia on being selected for the 2022 Harold Weintraub Graduate Student Award. The award, established by the Fred Hutchinson Cancer Research Center, is given yearly and recognizes outstanding achievement during graduate studies in the biological sciences [...]

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Arul Chinnaiyan, MD, PhD, selected for the Sjöberg Prize in Cancer Research

February 11, 2022 / Award

The Royal Swedish Academy of Sciences, which also awards the Nobel Prizes, announced today that Arul Chinnaiyan, MD, PhD, S.P. Hicks Professor of Pathology and Urology at Michigan Medicine and Director of the Michigan Center for Translational Pathology, has been selected as [...]

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Research from INHERET Published in JNCCN

January 18, 2022 / Publications

Research from INHERET was just published in the Journal of the National Comprehensive Cancer Network (JNCCN). Learn more about this study, which analyzes the implementation of InheRET's online tool that provides information about family history as it relates to cancer risks [...]

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Research Study Published in European Urology's Open Science

January 5, 2022 / Publications

 A multi-institutional study led by Drs. Alex Taylor, Noah Brown and Rohit Mehra from the Department of Pathology was just published in European Urology's Open Science. Learn more about the resarch, which focuses on how TERT promoter mutations were characterized in urinary tract lesions, which may be considered as precursors to neoplasia at this site [...]

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Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers

January 4, 2022 / Video

A chromatin degrader stops transcription factors from driving cancer, which may serve as a potential treatment approach for over 90% of prostate cancers.

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The Link Between Dysplastic Squamous Cells and Merkel Cell Carcinoma (MCC)

October 15, 2021 / Clinical Pathology

Research pertaining to Merkel cell carcinoma (MCC) and cutaneous neuroendocrine carcinomas was just published in the latest edition of Modern Pathology. Led by the team of Drs. Paul Harms, May Chan, Aaron Udager, Rajiv Patel, and more [...]

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Repurposing an anti-diabetic drug to reverse aberrant epigenetic pathways in childhood ependymomas.

October 7, 2021 / Experimental Pathology

Metformin holds promise against a rare type of childhood brain tumor in laboratory studies, as per an international team of researchers led by Dr. Sriram Venneti report in Science Translational Medicine. [...]

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Multi-Institutional Study Published on GI Adenomatoid Tumors

October 6, 2021 / Clinical Pathology

Research from experts in the Department of Pathology was published in Europe PMC's Histopathology. The team comprised of Drs. Jiaqi Shi, Laura Lamps and Erika Hissong examined the impact of adenomatoid tumors within the gastrointestinal tract [...]

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TRIM63 - What is it? (Hint: Not a weight-loss product)

August 9, 2021 / Publications

Dr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology  [...]

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Researchers Uncover Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer

August 3, 2021 / Blog

Findings offer clues to why some types of renal cell carcinoma respond to immunotherapy while others do not — it’s a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

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Researchers Develop First Inhibitors Against Key Epigenetic Complex Involved in Cancer

June 21, 2021 / Research

Activity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach. Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia [...]

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Research Published in Urologic Oncology's ScienceDirect

June 10, 2021 / Clinical Pathology

Research by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]

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Analysis Reveals How Kidney Cancer Develops and Responds to Treatment

June 10, 2021 / Mctp

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]

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Researchers Develop First-in-Class Inhibitors Against Key Leukemia Protein

May 17, 2021 / Michigan Health Blog

A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]

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Research from Lombard Lab Published in Journal of Clinical Investigation

May 12, 2021 / Publications

Research from the Department's Lombard Lab was just published in the Journal of Clinical Investigation. The study, which focuses on how the deacylase SIRT5 compound supports melanoma viability by influencing chromatin dynamics, was led by Dr. Lombard [...]

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Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer

May 12, 2021 / Mctp

Stopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.

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Arul Chinnaiyan, MD, PhD, Recognized for Outstanding Research

May 7, 2021 / Award

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “Exploring Precision Oncology: from Gene Fusions to Related Genetic Drivers“ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021 [...]

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Arul Chinnaiyan, MD, PhD Recognized for Outstanding Research

May 3, 2021 / Award

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “ “ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021.

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Research by Dr. Cho Published in AACR's "Cancer Research"

April 19, 2021 / Clinical Pathology

A new publication from the Department of Pathology, led by Dr. Kathleen Cho, was just published in the American Association for Cancer Research's flagship journal. highlights how altering the microbiome within a mouse model of oviductal high-grade serious carcinoma can inhibit tumorigeneis [...]

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Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

April 14, 2021 / Publications

MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.

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New Assay For Early Detection of Aggressive Prostate Cancers Developed

April 13, 2021 / Clinical Pathology

A new study, led by U-M graduate in molecular and cellular pathology Dr. Andi Cani, was just published in European Urology Oncology. The publication focuses on the development of a whole-urine, multiplexed, next-generation RNA-sequencing assay that is used for the early detection of aggressive forms of prostate cancer [...]

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"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra

March 9, 2021 / Video

Dr. Mehra discusses his career path and how he arrived at Michigan Medicine in our latest Careers in Pathology video.

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Prognostic Subgroups of Merkel Cell Carcinoma Defined

February 9, 2021 / Publications

A collaboration between the Department of Pathology and the Department of Dermatology examined biomarkers of outcomes in 346 cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The study was published in the recent edition of Clinical Cancer Research [...]

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The multi-faceted role of the SUV family of H3K9 methyltransferases

February 8, 2021 / Clinical Pathology

A new study from Drs. Andrew Muntean and Nirmalya Saha of the Department of Pathology's Muntean Lab was just published in Biochim et Biophysica (BBA) Reviews on Cancer. The research project sheds light on the multi-faceted role of the SUV family of H3K9 methyltransferases in carcinogenesis and within cancer progression.

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Research from Dr. Udager Published in European Urology

February 1, 2021 / Publications

A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]

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Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes

January 5, 2021 / Experimental Pathology

A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes. 

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Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead

December 22, 2020 / Michigan Health Blog

Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]

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Research Led by Drs. Cierpicki and Grembecka Published in "Blood"

December 2, 2020 / Clinical Pathology

A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]

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Dr. Thomas Giordano wins the AACR 2020 Team Science Award

November 30, 2020 / Experimental Pathology

Congratulations to Dr. Thomas Giordano and the entire Cancer Genome Atlas Project team for winning the American Association of Cancer Research's 2020 Team Science Award [...]

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Dr. Celina Kleer Wins ASIP 2020 Outstanding Investigator Award

November 12, 2020 / Experimental Pathology

Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]

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Understanding Breast Cancer: My Journey as a Physician-Scientist: Celina Kleer, MD

October 9, 2020 / Events

10:00 am EST

Join us for a virtual event featuring the Department of Pathology's Dr. Celina Kleer, who will host a discussion related to her experiences in understanding breast cancer and her journey as a physician-scientist.

Register Now

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Scientists Develop First Drug-Like Compounds to Inhibit Elusive Cancer-Linked Enzymes

September 2, 2020 / Michigan Health Blog

Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.

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Study from Venneti Lab on DIPGs Published in Cancer Cell

August 17, 2020 / Experimental Pathology

In a new study, Chan Chung et al. from the Venneti laboratory have discovered a “catch 22”-like phenomena, where epigenetic and metabolic pathways feed one another, in a childhood brain tumor called Diffuse Intrinsic Pontine Gliomas (DIPG) [...]

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Dr. Celina Kleer: Physician Scientist, Dedicated Mentor, ASIP Outstanding Investigator Awardee

July 20, 2020 / Clinical Pathology

Dr. Celina Kleer named 2019 AACR Outstanding Investigator in Breast Cancer Research

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Dr. Udager Appears on '3Ps of Cancer' Podcast

July 14, 2020 / News

Dr. Aaron Udager recently appeared on Michigan Medicine's 3P's of Cancer: Prevention, Preparedness, Progress podcast

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Research Regarding Microcystic Adnexal Carcinomas Published

June 11, 2020 / Experimental Pathology

The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

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U-M Researchers Home in on Key Player in Pancreatic Cancer Development

June 4, 2020 / Experimental Pathology

The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

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Research Regarding Invasive Squamous Cell Carcinoma Published

May 29, 2020 / Experimental Pathology

The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

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Research about Renal Cell Carcinoma in Young Adults Published

May 22, 2020 / Experimental Pathology

The research was just published in Histopathology and features prominent contributions from our faculty.

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Diagnostic Biomarkers Uncovered for Rare Kidney Cancer

April 21, 2020 / Experimental Pathology

Researchers have uncovered the gene signature for ChRCC.

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Marcin Cieslik Receives Award from Bristol-Myers Squibb

March 11, 2020 / Experimental Pathology

Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.

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Anti-Leukemia Compound Induces Complete Remission in Mouse Models

February 3, 2020 / Experimental Pathology

A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.

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Cervical Health Awareness Month

January 24, 2020 / Anatomic Pathology

January is Cervical Health Awareness Month. While cervical health is important twelve months of the year, it’s a great time to schedule necessary appointments and screenings. According to Dr. Richard Lieberman, with regular health screenings and the use of pap-smear testing, death rates from cervical cancer have dropped 90% since 1943. [...]

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A Simple Twist of Cell Fate

January 15, 2020 / Experimental Pathology

U-M researchers are shedding new light with exciting implications for research and health.

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Dr. Chan Chung Receives Two Grants to Study Brain Cancers

January 9, 2020 / Experimental Pathology
 

Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]

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Andi Cani becomes Dr. Cani

December 23, 2019 / Phd Program
 

Andi Cani, PhD, successfully defended his thesis entitled “Precision Medicine Approaches to Hormone-Driven Cancer” on December 5, 2019. [...]

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R01 Granted to Jolanta Grembecka, PhD

December 20, 2019 / Award

We are thrilled to announce that Jolanta Grembecka, PhD, an Associate Professor in Pathology, has been granted an R01 for her research “Development of ASH1L inhibitors for acute leukemia.” [...]

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Abhijit Parolia is Awarded The NCI Predoctoral to Postdoctoral Fellow Transition Award

December 2, 2019 / Announcement
 

The National Cancer Institute’s (NCI) Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding PhD and other Research Doctoral candidates who complete their dissertation research training (F99 phase) and transition in a timely manner to mentored, cancer-focused postdoctoral career development research positions (K00 phase). [...]

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Kleer honored by the AACR

November 4, 2019 / Award

The American Association for Cancer Research announced that Celina Kleer, MD, the Harold A. Oberman Collegiate Professor of Pathology and Director of the Breast Pathology Program, will be the recipient of the 2019 Outstanding Investigator in Breast Cancer Research, supported by the Breast Cancer Research Foundation.

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A Fundamental Passion

October 18, 2019 / Faculty Spotlight

Bryan Betz, PhD, was inspired by his late wife, Sharon, to pursue a career in clinical diagnostics.

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Cancer Patients Want to Pull Back the Curtain on Pathology

October 10, 2019 / Michigan Health Blog

Speaking directly with a pathologist could help patients better understand their diagnosis and feel empowered, a survey of patient sentiment finds.

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Dr. Surinder Kumar Receives The Pablove Foundation Childhood Cancer Research Grant

September 18, 2019 / Experimental Pathology

Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]

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September is Prostate Cancer Awareness Month

September 17, 2019 / Experimental Pathology

Every year in the United States, nearly 3 million men hear the words, “You have prostate cancer.” That is 1 in 9 men each year.  The word “cancer” triggers an immediate response in most people…fear, worry about family, denial, and often an increased awareness of one’s mortality. [...]

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Newly Defined Cancer Driver is Fast, Furious, and Loud

June 19, 2019 / Experimental Pathology

Researchers characterize 3 ways in which the gene FOXA1 mutates to trigger prostate cancer.

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Asking Tough Questions

July 31, 2018 / Experimental Pathology

Triple-negative breast cancers account for just 15-20% of breast cancers, but a disproportionate number of deaths. A Nature Communications paper from the Kleer Lab, in close collaboration with other U-M Department of Pathology labs, has discovered a reason why and could lead to better outcomes for patients.

Celina Kleer, MD’s lab in the Rogel Cancer Center is occupied by staff and students with a range of experiences and talents, but a common goal – understanding difficult breast cancers [...] 

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