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Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.

April 14 2021
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"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra

Dr. Mehra discusses his career path and how he arrived at Michigan Medicine in our latest Careers in Pathology video.

March 9 2021

Prognostic Subgroups of Merkel Cell Carcinoma Defined

A collaboration between the Department of Pathology and the Department of Dermatology examined biomarkers of outcomes in 346 cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The study was published in the recent edition of Clinical Cancer Research [...]

February 9 2021

Research from Dr. Udager Published in European Urology

A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]

February 1 2021

Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes

A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes. 

January 5 2021

Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead

Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]

December 22 2020

Research Led by Drs. Cierpicki and Grembecka Published in "Blood"

A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]

December 2 2020

Dr. Thomas Giordano wins the AACR 2020 Team Science Award

Congratulations to Dr. Thomas Giordano and the entire Cancer Genome Atlas Project team for winning the American Association of Cancer Research's 2020 Team Science Award [...]

November 30 2020

Dr. Celina Kleer Wins ASIP 2020 Outstanding Investigator Award

Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]

November 12 2020

Understanding Breast Cancer: My Journey as a Physician-Scientist: Celina Kleer, MD

10:00 am EST

Join us for a virtual event featuring the Department of Pathology's Dr. Celina Kleer, who will host a discussion related to her experiences in understanding breast cancer and her journey as a physician-scientist.

Register Now

October 9 2020

Scientists Develop First Drug-Like Compounds to Inhibit Elusive Cancer-Linked Enzymes

Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.

September 2 2020

Study from Venneti Lab on DIPGs Published in Cancer Cell

In a new study, Chan Chung et al. from the Venneti laboratory have discovered a “catch 22”-like phenomena, where epigenetic and metabolic pathways feed one another, in a childhood brain tumor called Diffuse Intrinsic Pontine Gliomas (DIPG) [...]

August 17 2020

Dr. Celina Kleer: Physician Scientist, Dedicated Mentor, ASIP Outstanding Investigator Awardee

Dr. Celina Kleer named 2019 AACR Outstanding Investigator in Breast Cancer Research

July 20 2020

Dr. Udager Appears on '3Ps of Cancer' Podcast

Dr. Aaron Udager recently appeared on Michigan Medicine's 3P's of Cancer: Prevention, Preparedness, Progress podcast

July 14 2020

Research Regarding Microcystic Adnexal Carcinomas Published

The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

June 11 2020

U-M Researchers Home in on Key Player in Pancreatic Cancer Development

The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

June 4 2020

Research Regarding Invasive Squamous Cell Carcinoma Published

The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

May 29 2020

Research about Renal Cell Carcinoma in Young Adults Published

The research was just published in Histopathology and features prominent contributions from our faculty.

May 22 2020
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Diagnostic Biomarkers Uncovered for Rare Kidney Cancer

Researchers have uncovered the gene signature for ChRCC.

April 21 2020

Marcin Cieslik Receives Award from Bristol-Myers Squibb

Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.

March 11 2020
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Anti-Leukemia Compound Induces Complete Remission in Mouse Models

A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.

February 3 2020

Cervical Health Awareness Month

January is Cervical Health Awareness Month. While cervical health is important twelve months of the year, it’s a great time to schedule necessary appointments and screenings. According to Dr. Richard Lieberman, with regular health screenings and the use of pap-smear testing, death rates from cervical cancer have dropped 90% since 1943. [...]

January 24 2020
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A Simple Twist of Cell Fate

U-M researchers are shedding new light with exciting implications for research and health.

January 15 2020

Dr. Chan Chung Receives Two Grants to Study Brain Cancers

 

Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]

January 9 2020

Andi Cani becomes Dr. Cani

 

Andi Cani, PhD, successfully defended his thesis entitled “Precision Medicine Approaches to Hormone-Driven Cancer” on December 5, 2019. [...]

December 23 2019

R01 Granted to Jolanta Grembecka, PhD

We are thrilled to announce that Jolanta Grembecka, PhD, an Associate Professor in Pathology, has been granted an R01 for her research “Development of ASH1L inhibitors for acute leukemia.” [...]

December 20 2019

Abhijit Parolia is Awarded The NCI Predoctoral to Postdoctoral Fellow Transition Award

 

The National Cancer Institute’s (NCI) Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding PhD and other Research Doctoral candidates who complete their dissertation research training (F99 phase) and transition in a timely manner to mentored, cancer-focused postdoctoral career development research positions (K00 phase). [...]

December 2 2019

Kleer honored by the AACR

The American Association for Cancer Research announced that Celina Kleer, MD, the Harold A. Oberman Collegiate Professor of Pathology and Director of the Breast Pathology Program, will be the recipient of the 2019 Outstanding Investigator in Breast Cancer Research, supported by the Breast Cancer Research Foundation.

November 4 2019
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A Fundamental Passion

Bryan Betz, PhD, was inspired by his late wife, Sharon, to pursue a career in clinical diagnostics.

October 18 2019
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Cancer Patients Want to Pull Back the Curtain on Pathology

Speaking directly with a pathologist could help patients better understand their diagnosis and feel empowered, a survey of patient sentiment finds.

October 10 2019

Dr. Surinder Kumar Receives The Pablove Foundation Childhood Cancer Research Grant

Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]

September 18 2019

September is Prostate Cancer Awareness Month

Every year in the United States, nearly 3 million men hear the words, “You have prostate cancer.” That is 1 in 9 men each year.  The word “cancer” triggers an immediate response in most people…fear, worry about family, denial, and often an increased awareness of one’s mortality. [...]

September 17 2019
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Newly Defined Cancer Driver is Fast, Furious, and Loud

Researchers characterize 3 ways in which the gene FOXA1 mutates to trigger prostate cancer.

June 19 2019