Pathology News Archive: Kleer Lab

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Dr. Celina Kleer: Physician Scientist, Dedicated Mentor, ASIP Outstanding Investigator Awardee

Dr. Celina Kleer named 2019 AACR Outstanding Investigator in Breast Cancer Research

July 20 2020

Study from Kleer and Nesvizhskii Labs Reveals the Proteomic Landscape of Metaplastic Breast Carcinomas

Along with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]

May 1 2020

Kleer honored by the AACR

The American Association for Cancer Research announced that Celina Kleer, MD, the Harold A. Oberman Collegiate Professor of Pathology and Director of the Breast Pathology Program, will be the recipient of the 2019 Outstanding Investigator in Breast Cancer Research, supported by the Breast Cancer Research Foundation.

November 4 2019
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By Cannibalizing Nearby Stromal Stem Cells, Some Breast Cancer Cells Gain Invasion Advantage

Cancer biologists and engineers collaborated on a device that could help predict the likelihood of breast cancer metastasis.

July 2 2019
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New Mechanism in Aggressive Breast Cancer Discovered

A collaboration out of the Molecular and Cellular Pathology graduate program could lead to new treatment strategies.

October 3 2018

Celina G. Kleer, MD selected for the 2018 MICHR Distinguished Clinical and Translational Research Mentor Award

Congratulations to Dr. Celina Kleer, the Harold A. Oberman Collegiate Professor of Pathology, who has been selected as the 2018 recipient of the 7th Annual MICHR Distinguished Clinical and Translational Research Mentor Award!

Dr. Kleer was nominated by her trainees as well as peers at U-M Medical [...]

June 18 2018
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Congratulations to Talha Anwar for a successful defense of his PhD Thesis with the mentorship of Dr. Celina Kleer

 

Talha Anwar is in the Medical Scientist Training Program (MSTP) and the Molecular and Cellular Pathology Program at U-M. He defended his PhD thesis, Regulation of EZH2 in triple-negative breast cancer, on Friday April 6, 2018 [...]

April 10 2018

New Breast Cancer Metastasis Mechanism Uncovered

The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, isolated human mesenchymal stem cells from breast cancer metastasis. The lab discovered that a collagen receptor tyrosine kinase, DDR2, mediates stromal-cancer communication and induces breast cancer metastasis. The study provides the basis for the development of DDR2 inhibitors. The article appeared in Cell Reports and can be found at www.cell.com.

January 31 2017
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What Cancer Patients Should Know About Their Pathology Reports

If you have cancer, the treatment plan probably started with a pathologist’s review of your biopsy

January 24 2017

Kleer lab develops model of human metaplastic breast carcinomas

The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, discovered that mammary-specific knock down of CCN6 results in mammary carcinomas with features of human metaplastic carcinomas. This model may lead to discovery of new diagnostic and therapeutic targets for this rare and aggressive form of triple negative breast cancer. The article appeared in Oncogene, on the November 7th 2016 issue, and can be found at www.nature.com

December 5 2016
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Facing Fears to Improve Patient Care

Group photo of a portion of the breast team (left to right) Drs. Celina Kleer, Laura Walters, Judy Pang, Ghassan Allo In 2008, the Division of Surgical Oncology moved outpatient breast surgeries offsite from the University Hospital (UH) to East Ann Arbor Ambulatory Surgery Center (EAA), about 5.5 miles away. While EAA had six operating rooms, there was no surgical pathology lab on-site. Specimens removed during surgery had to be transported to UH . . .
July 10 2015

Pre-doctoral Graduate Student Receiving a Ruth L. Kirschstein National Research Service Award (NRSA)

Congratulations to Talha Anwar, pre-doctoral graduate student in the Kleer lab on receiving a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD Fellowship (F30). This three year grant will support Talha's thesis project titled "Non-canonical functions of EZH2 in triple-negative breast cancers." His project investigates the mechanistic and functional contributions of EZH2, a protein found signif . . .
April 30 2015