New Breast Cancer Metastasis Mechanism Uncovered

By Celina Kleer | January 31 2017

The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, isolated human mesenchymal stem cells from breast cancer metastasis. The lab discovered that a collagen receptor tyrosine kinase, DDR2, mediates stromal-cancer communication and induces breast cancer metastasis. The study provides the basis for the development of DDR2 inhibitors. The article appeared in Cell Reports and can be found at www.cell.com.