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Research Study Published in European Urology's Open Science
January 5, 2022 / FacultyA multi-institutional study led by Drs. Alex Taylor, Noah Brown and Rohit Mehra from the Department of Pathology was just published in European Urology's Open Science. Learn more about the resarch, which focuses on how TERT promoter mutations were characterized in urinary tract lesions, which may be considered as precursors to neoplasia at this site [...]
Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers
January 4, 2022 / MctpA chromatin degrader stops transcription factors from driving cancer, which may serve as a potential treatment approach for over 90% of prostate cancers.
The Link Between Dysplastic Squamous Cells and Merkel Cell Carcinoma (MCC)
October 15, 2021 / Clinical PathologyResearch pertaining to Merkel cell carcinoma (MCC) and cutaneous neuroendocrine carcinomas was just published in the latest edition of Modern Pathology. Led by the team of Drs. Paul Harms, May Chan, Aaron Udager, Rajiv Patel, and more [...]
TRIM63 - What is it? (Hint: Not a weight-loss product)
August 9, 2021 / CancerDr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology [...]
Researchers Develop First Inhibitors Against Key Epigenetic Complex Involved in Cancer
June 21, 2021 / LeukemiaActivity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach. Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia [...]
Research Published in Urologic Oncology's ScienceDirect
June 10, 2021 / CancerResearch by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]
Analysis Reveals How Kidney Cancer Develops and Responds to Treatment
June 10, 2021 / MctpNot all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]
Researchers Develop First-in-Class Inhibitors Against Key Leukemia Protein
May 17, 2021 / CancerA research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]
Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer
May 12, 2021 / MctpStopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.
Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype
April 14, 2021 / Cancer ResearchMiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.
Prognostic Subgroups of Merkel Cell Carcinoma Defined
February 9, 2021 / CancerA collaboration between the Department of Pathology and the Department of Dermatology examined biomarkers of outcomes in 346 cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The study was published in the recent edition of Clinical Cancer Research [...]
The multi-faceted role of the SUV family of H3K9 methyltransferases
February 8, 2021 / Clinical PathologyA new study from Drs. Andrew Muntean and Nirmalya Saha of the Department of Pathology's Muntean Lab was just published in Biochim et Biophysica (BBA) Reviews on Cancer. The research project sheds light on the multi-faceted role of the SUV family of H3K9 methyltransferases in carcinogenesis and within cancer progression.
Research from Dr. Udager Published in European Urology
February 1, 2021 / CancerA new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]
Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes
January 5, 2021 / CancerA new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes.
Research Led by Drs. Cierpicki and Grembecka Published in "Blood"
December 2, 2020 / CancerA new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]
Global Virtual Cancer Conference: Dr. Jeffrey Myers
November 11, 2020 / CancerIntroducing the 2020 Global Virtual Cancer Conference. Join us for the segment entitled "Prevention, Diagnosis and Me" to hear from the Department of Pathology's own Dr. Jeffrey Myers, who will discuss his experiences working in the cancer community [...]
Scientists Develop First Drug-Like Compounds to Inhibit Elusive Cancer-Linked Enzymes
September 2, 2020 / Rogel Cancer CenterStructural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.
Dr. Udager Appears on '3Ps of Cancer' Podcast
July 14, 2020 / CancerDr. Aaron Udager recently appeared on Michigan Medicine's 3P's of Cancer: Prevention, Preparedness, Progress podcast
Research Regarding Microcystic Adnexal Carcinomas Published
June 11, 2020 / Cancer ResearchThe research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.
Study from Kleer and Nesvizhskii Labs Reveals the Proteomic Landscape of Metaplastic Breast Carcinomas
May 1, 2020 / Breast CancerAlong with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]
Diagnostic Biomarkers Uncovered for Rare Kidney Cancer
April 21, 2020 / Experimental PathologyResearchers have uncovered the gene signature for ChRCC.
Anti-Leukemia Compound Induces Complete Remission in Mouse Models
February 3, 2020 / Experimental PathologyA Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.
Cervical Health Awareness Month
January 24, 2020 / Anatomic PathologyJanuary is Cervical Health Awareness Month. While cervical health is important twelve months of the year, it’s a great time to schedule necessary appointments and screenings. According to Dr. Richard Lieberman, with regular health screenings and the use of pap-smear testing, death rates from cervical cancer have dropped 90% since 1943. [...]
A Simple Twist of Cell Fate
January 15, 2020 / Experimental PathologyU-M researchers are shedding new light with exciting implications for research and health.
PCR-based TERT Promoter Assays Aid in Bladder Cancer Diagnosis
October 30, 2019 / PublicationsOur department's clinical resident Alex Taylor, MD, joined postdoctoral fellow Rahul Mannon, PhD, and other researchers from the Department of Pathology and the Michigan Center for Translational Pathology, who found that patients with a long-standing history of prostate cancer and other prostatic issues can find difficulty [...]
A Fundamental Passion
October 18, 2019 / InsidepathBryan Betz, PhD, was inspired by his late wife, Sharon, to pursue a career in clinical diagnostics.
Cancer Patients Want to Pull Back the Curtain on Pathology
October 10, 2019 / Michigan Health BlogSpeaking directly with a pathologist could help patients better understand their diagnosis and feel empowered, a survey of patient sentiment finds.
September is Prostate Cancer Awareness Month
September 17, 2019 / CancerEvery year in the United States, nearly 3 million men hear the words, “You have prostate cancer.” That is 1 in 9 men each year. The word “cancer” triggers an immediate response in most people…fear, worry about family, denial, and often an increased awareness of one’s mortality. [...]
Making Sense Out of Tragedy
September 17, 2019 / PhilanthropyA gift from the Silver Family Foundation is funding research at Michigan Medicine.
New Tool Helps Identify Patients at Risk for Hereditary Cancers
July 3, 2019 / AnnouncementLynn McCain and Drs. David Keren and Lee Schroeder are part of a multidisciplinary team at Michigan Medicine and Rogel Cancer Center who have developed an online tool to help identify those at risk for familial cancers. InheRET, which has already [...]
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