News Archive

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Large study identifies biomarkers for rare kidney tumors

May 15, 2024 / Proteomics

With 20 subtypes of Renal Cell Carcinoma (RCC) listed by the World Health Organization in 2022, determining the specific type of RCC and the correct treatment protocol for patients can be daunting. Only seven of the 20 subtypes had been defined by specific molecular changes and the 20% of RCCs that are classified as non-clear cell RCCs (non-ccRCC), were primarily identified only by histopathologic features. The driving genetic changes had not been identified. A large multi-institutional team making up the Clinical Proteomic Tumor Analysis Consortium, including several researchers from Michigan Medicine’s Department of Pathology, performed multi-omics data analysis on 48 non-ccRCC and 103 ccRCC tumors as well as 101 normal adjacent tissues to study the genetic aberrations found in these tumor types. The findings of this research were recently published in Cell Reports Medicine, with Pathology’s Drs. Alexey Nesvizhskii and Saravana Mohan Dhanasekaran as senior authors and Dr. Ginny Xiaohe Li as first author.

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Kevin Yang, Nesvizhskii Lab, publishes first first-author publication

August 8, 2023 / Phd Program

Congratulations to Kevin Yang (Ph.D. student in the Nesvizhskii lab) on his first first-author publication in Nature Communications! In a manuscript published in Nature Communications, Ph.D. student Kevin Yang, from the Alexey Nesvizhskii lab, presented a new computational tool, MSBooster [...].