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A new cooperation between EZH2 and p38 proteins enhances metastasis in triple negative breast cancer
August 17, 2022 / Experimental PathologyThe Celina Kleer lab at the University of Michigan Department of Pathology and Rogel Cancer Center has found a new mechanism that fuels metastasis in triple negative breast cancers. In their new study they show that EZH2, a master regulator of cell type identity, known to function through methylation of histones, has a new, unexpected function in aggressive breast cancers [...]
Dr. Celina Kleer Wins ASIP 2020 Outstanding Investigator Award
November 12, 2020 / AsipCongratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]
Understanding Breast Cancer: My Journey as a Physician-Scientist: Celina Kleer, MD
October 9, 2020 / Events10:00 am EST
Join us for a virtual event featuring the Department of Pathology's Dr. Celina Kleer, who will host a discussion related to her experiences in understanding breast cancer and her journey as a physician-scientist.
Study from Kleer and Nesvizhskii Labs Reveals the Proteomic Landscape of Metaplastic Breast Carcinomas
May 1, 2020 / Breast CancerAlong with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]
Kleer honored by the AACR
November 4, 2019 / Rogel Cancer CenterThe American Association for Cancer Research announced that Celina Kleer, MD, the Harold A. Oberman Collegiate Professor of Pathology and Director of the Breast Pathology Program, will be the recipient of the 2019 Outstanding Investigator in Breast Cancer Research, supported by the Breast Cancer Research Foundation.
Asking Tough Questions
July 31, 2018 / Experimental PathologyTriple-negative breast cancers account for just 15-20% of breast cancers, but a disproportionate number of deaths. A Nature Communications paper from the Kleer Lab, in close collaboration with other U-M Department of Pathology labs, has discovered a reason why and could lead to better outcomes for patients.
Celina Kleer, MD’s lab in the Rogel Cancer Center is occupied by staff and students with a range of experiences and talents, but a common goal – understanding difficult breast cancers [...]
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