The Nunez Laboratory

Home Relevant Publications Publications Lab Members Contact Us

University of Michigan

PUBMED UM Directory University of Michigan Wolverine Access
  1. Home
  2. Full List of Publications

 

Peer Reviewed

  1. Nuñez A, Martinez F, Gomez P, Nuñez G, Torres A.  Possible HLA role in a family with Hodgkin’s disease.  Tissue Antigens. 13:377-378 (1979).
  2. Nuñez A, Arnaiz A, Nuñez G.  Genetic control by the HLA region of the immune response to factor VIII in hemophilic patients.  CR Acad Sci (Paris). 341 (1979).
  3. Ugolini V, Nuñez G, Smith G, Stastny P, Capra JD.  Initial characterization of monoclonal antibodies against human monocytes.  Proc Natl Acad Sci USA.  77:6764‑6788 (1980).
  4. Nuñez G, McPhaul JJ Sr., Stastny P.  Characterization of B cell and monocyte antibodies in recipient sera and elutes from rejected kidney allografts.  Transplant Proc.  13:111-113 (1980).
  5. Nuñez G, Ugolini V, Capra JD, Stastny P.  Monoclonal antibodies against human monocytes.  II.  Recognition of two distinct surface molecules.  Scand J Immunol.  16:515-523 (1982).
  6. Hurley CM, Nuñez G, Winchester R, Finn OJ, Levy R, Capra JD.  The human HLA‑DR antigens are encoded by multiple beta chain loci.  J Immunol.  129:2103-2108 (1982).
  7. Nuñez G, McPhaul JJ Sr., Stastny P.  Characterization of B cell antibodies in kidney transplant recipients.  Transplantation. 35:446-452 (1983).
  8. Nuñez G, Stastny P.  Cytofluorometric analysis of major histocompatibility antigens on human monocytes using monoclonal antibodies.  Human Immmunol.  6:1-11 (1983).
  9. Giles RC, Nuñez G, Hurley CK, Nuñez-Roldan A, Winchester R, Stastny P, Capra JD.  Structural analysis of a human I-A homologue using a monoclonal antibody that recognizes an MB3-like specificity.  J Exp Med.  157:1461-1470 (1983).
  10. Nuñez G, Ball EJ, Stastny P.  Accessory cell function of human endothelial cells.  I.  A subpopulation of Ia positive cells is required for antigen presentation.  J Immunol.  131:666-673 (1983).
  11. Nuñez G, Moore SE, Ball GV, Hurd ER, Stastny P.  Study of HLA antigens in ten multiple-case rheumatoid arthritis families.  J Rheumatol.  11:129-135 (1984).
  12. Toews GB, Vial WC, Dunn MM, Guzzetta P, Nuñez, G, Stastny P, Lipscomb MF.  The accessory cell function of human alveolar macrophages in specific T cell proliferation.  J Immunol. 132:181-186 (1984).
  13. Hurley CK, Giles RC, Nuñez G, DeMars R, Nadler L, Winchester R, Stastny P, Capra JD.  Molecular localization of human class II MT2 and MT3 determinants.  J Exp Med.  160:472-493 (1984).
  14. Nuñez G, Giles RC, Ball EJ, Hurley CJ, Capra JD, Stastny P.  Expression of HLA‑DR, MB, MT and SB antigens on human mononuclear cells:  Identification of two phenotypically distinct monocyte populations.  J Immunol.  133:1300-1306 (1984).
  15. Neppert J, Nuñez G, Stastny P.  HLA-A, B, C:  -DR, MT, -MB, and SB antigens on unstimulated human endothelial cells.  Tissue Antigens.  24:40-47 (1984).
  16. Stastny P, Nuñez G, Myers L, Ball EJ.  Survey of workshop monoclonal antibodies by inhibition of fluorescein-labeled reference monoclonal reagents, double labeling studies on monocytes, and inhibition of T cell recognition of class II antigens.  Disease Markers.  2:57-67 (1984).
  17. Lem VM, Lipscomb MF, Weissler JC, Nuñez G, Ball EJ, Stastny P, Toews GB.  Bronchoalveolar cells from sarcoid patients demonstrate enhanced antigen presentation.  J Immunol.  135:1766-1771 (1985).
  18. Nuñez G, Ball EJ, Myers LK, Stastny P.  Allostimulating cells in man.  Quantitative variation in the expression of HLA-DR and HLA-DQ molecules influences T cell activation.  Immunogenetics.  22:85-91 (1985).
  19. Toews GB, Lem VM, Weissler JC, Nuñez G, Ball EJ, Stastny P, Lipscomb MF.  Antigen presentation by alveolar macrophages in patients with sarcoidosis.  Ann NY Acad Sci.  46:74-81 (1986).
  20. Shannon KD, Nuñez G, Dow LW, Weinberg AG, Sato Y, Stastny P, Buchanan GR.  Juvenile chronic myelogenous leukemia with prominent erythrophagocytosis.  Analysis by monocyte-specific monoclonal antibodies, in vitro colony formation, and cytogenetics.  Pediatrics.  77:330-335 (1986).
  21. Nuñez G, Stastny P.  Assignment of determinants recognized by alloantisera to HLA-D subregion molecules by a lysostripping technique.  Tissue Antigens.  27:185-195 (1986).
  22. Lipscomb MF, Lyons CR, Nuñez G, Ball EJ, Stastny P, Vial W, Lem V, Weissler J, Miller LM, Toews GB.  Human alveolar macrophages:  HLA-DR-positive macrophages that are poor stimulators of a primary mixed leukocyte reaction.  J Immunol.  136:497-504 (1986).
  23. Stastny P, Myers LK, Nuñez G, Hoover ML, Capra JC, Ball EJ.  Molecular genetics and T cells in autoimmunity.  Ann NY Acad Sci.  475:12-23 (1986).
  24. Myers LK, Ball EJ, Nuñez G, Stastny P.  Recognition of class II molecules by human T cells.  I. Analysis of epitopes of DR and DQ molecules in a DRw11, DRw52, DQ3 haplotype.  Immunogenetics. 23:142-150 (1986).
  25. Southeimer RD, Stastny P, Nuñez G.  HLA-D region antigen expression by human epidermal Langerhans cells.  J Invest Dermatol.  87:707-710 (1986).
  26. Nuñez G, Ball EJ, Stastny P.  Antigen presentation by adherent cells from human peripheral blood:  Correlation between expression of HLA-DR and HLA-DO antigens and T cell activation.  Human Immunol.  19:29-39 (1987).
  27. Myers LK, Ball EJ, Nuñez G, Fink CW.  HLA-D region epitopes associated with juvenile arthritis:  Recognition by alloreactive T cell clones and alloantisera.  Arthritis Rheum.  30:744-751 (1987).
  28. McDonnell TJ, Deane N, Platt FM, Nuñez G, Jaeger U, McKearn JP, Korsmeyer SJ.  Bcl-2 immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.  Cell.  57:79-88 (1989).
  29. Nuñez G, Seto M, Seremetis S, Ferrero D, Grignani F, Korsmeyer SJ, Dalla-Favera R.  Growth and tumor promoting effects of deregulated Bcl-2 in human B lymphoblastoid cells.  Proc Natl Acad Sci USA.  86:4589-4593 (1989).
  30. Hockett RK, Nuñez G, Korsmeyer SJ.  Evolutionary comparison of murine and human d T cell receptor eliminating elements.  New Biologist.  1:266-274 (1989).
  31. Nuñez G, London L, Hockenberry D, Alexander M, McKearn JP, Korsmeyer SJ.  Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor deprived hematopoietic cell lines.  J Immunol.  144:3602-3610 (1990).
  32. McDonnell TJ, Nuñez G, Platt FM, Hockenberry D, London L, McKearn JP, Korsmeyer SJ.  Deregulated Bcl-2-Ia transgene expands a resting but responsive IgM/IgD B cell population.  Mol Cell Biol.  10:1901-1907 (1990).
  33. Hockenberry DM, Nuñez G, Milliman C, Screiber RD, Korsmeyer SJ.  Bcl-2, an inner mitochondrial membrane protein blocks programmed cell death.  Nature (London).  348:334-338 (1990).
  34. Nuñez G, Hockenberry D, McDonnell TJ, Sorensen CM, Korsmeyer SJ.  Bcl-2 maintains B cell memory.  Nature (London).  353:71-73 (1991).
  35. Gratiot-Deans J, Ding L, Turka LA, Nuñez G.  Bcl-2 proto-oncogen expression during human T cell development:  Evidence for biphasic regulation.  J Immunol.  151:83-91 (1993).
  36. Cuende E, Ding L, Ales-Martinez JE, Gonzalez-Garcia M, Martinez-A C, Nuñez G.  Programmed cell death by Bcl-2 dependent and independent mechanisms in B-cell lymphoma cells.  EMBO J.  12:1555-1560 (1993).
  37. Boise LH, Gonzalez-Garcia M, Postema C, Ding L, Lindsten T, Turka L, Mao X, Nuñez G, Thompson C.  Bcl-x, a Bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.  Cell.  74:597-608 (1993).
  38. Castle V, Heidelberger KP, Bromberg J, Ou X, Dale M, Nuñez G.  Expression of the apoptosis-suppressing protein Bcl-2 in Neuroblastoma is associated with unfavorable history and N-myc amplification.  Am J Pathol.  143:1543-1550 (1993).
  39. Merino R, Ding L, Veis D, Korsmeyer SJ, Nuñez G.  Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.  EMBO J.  13:683-691 (1994).
  40. Gottschalk AR, McShan CL, Merino R, Nuñez G, Quintans J.  Physiological cell death in B lymphocytes.  I. Differential susceptibility of WEHI-231 sublines to anti-Ig induced physiological cell death and lack of correlation with Bcl-2 expression.  Int Immunol.  6:121-130 (1994).
  41. González-García M, Ballestero R, Ding L, Duan L, Boise L, Thompson C, Nuñez G.  Bcl-xL is the major Bcl-x in RNA from expressed during murine development and its product localizes to mitochondria.  Development.  120:3033-3042 (1994).
  42. Dole MG, Nuñez G, Merchant A, Maybaum J, Rode C, Bloch CA, Castle VP.  Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.  Cancer Res.  54(12):3253-3259 (1994).
  43. Ryan J, Gottlieb C, Merino R, Nuñez G, Clarke M.  Alteration of the cell cycle regulatory function of p53 by Bcl-2.  Proc Natl Acad Sci USA.  91:5878-5882 (1994).
  44. Lam L, Dubyak G, Chen L, Nuñez G, Miesfeld RL, Distelhorst CW.  Evidence that Bcl‑2 blocks glucocorticoid- and thapsigargin-induced apoptosis of mouse lymphoma cells by interfering with calcium mobilization from the endoplastic reticulum.  Proc Natl Acad Sci USA.   91:6569-6573 (1994).
  45. Cleveland J, Troppmair J, Packham G, Askew D, Lloyd P, Gonzalez-García M, Nuñez G, Ihle J.  v-raf suppresses apoptosis and promotes growth of interleukin 3-dependent myeloid cells.  Oncogene.  9:2217-2226 (1994).
  46. Nuñez G, Merino R, Grillot D, Gonzalez-García M.  Bcl-2 and Bcl-x:  Regulatory switches for cell death and survival.  Immunol Today.  15:582-588 (1994).
  47. Nuñez G, Clarke M.  The Bcl-2 family of proteins: regulators of cell death and survival.  Trends Cell Biol.  4:399-403 (1994).
  48. Gratiot-Deans J, Merino R, Nuñez G, Turka LA.  Bcl-2 expression during T cell development:  Early loss and late return occurs at specific stages of commitment to differentiation and survival.  Proc Natl Acad Sci USA.  91:10685-10689 (1994).
  49. Benito A, Grillot D, Nuñez G, Fernández-Luna JL.  Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.  Am J Pathol.  146:481-490 (1995).
  50. Gonzalez-García M, Garcia I, Ding L, O’Shea S, Boise LH, Thompson CB, Nuñez G.  Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.  Proc Natl Acad Sci USA.  92; 3404-3408 (1995).
  51. Wrone-Smith T, Johnson T, Nelson B, Boise LH, Thompson C, Nuñez G, Nickoloff BJ.  Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo.  Am J Pathol.  146:1079-1088 (1995).
  52. Fukunaga-Johnson Nina, Ryan JJ, Wicha M, Nuñez G, Clarke MF.  Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death.  Carcinogenesis.  16:1761-1767 (1995).
  53. Dole, MG, Jasty R, Cooper M, Thompson CB, Nuñez G, Castle VP.  Bcl-xl is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.  Cancer Res.  55:2576-2582 (1995).
  54. Grillot D, Merino R-M, Nuñez G.  Bcl-xL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.  J Exp Med.  182:1973-1983 (1995).
  55. Clarke MF, Apel IJ, Eipers EG, Sunantran V, Gonzalez-García M, Benedict M, Fukunaga N, Davidson B, Minn AJ, Boise LH, Thompson CB, Wicha M, Nuñez G.  A recombinant Bcl-xS adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.  Proc Natl Acad Sci USA.  92(24):11024-11028 (1995).
  56. Sunantran VN, Ealovega MW, Nuñez G, Clarke MF, Wicha MS.  Overexpression of Bcl-xS sensitizes MCF-7 cells to chemotherapy-induced apoptosis.  Cancer Res.  55:2507-2510 (1995).
  57. Merino R, Grillot DAM., Simonian PL, Muthukkumar S, Fanslow WC, Bondada S, Nuñez G.  Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40:  Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction.   J Immunol.  155:3830-3838 (1995).
  58. Schott AF, Apel IJ, Nuñez G, Clarke MF.  Bcl-xL protects cancer cells from p53‑mediated apoptosis.  Oncogene.  11:1389-1394 (1995).
  59. Dole MG, Clarke MF, Eipers P, Jasty R, Thompson CB, Rhode C, Bloch C, Nuñez G, Castle VP.  Bcl-xS induces apoptosis in neuroblastoma cells even in the presence of high levels of Bcl-xL and Bcl-2.  Cancer Res.  55:2576-2682 (1995).
  60. Varani K, Dame MK, Taylor CG, Sarma V, Merino R, Kunkel RG, Nuñez G, Dixit VM.  Age-dependent injury in human umbilical vein endothelial cells: relationship to apoptosis and correlation with a lack of A20 expression.  Lab Invest.  73:851-858 (1995).
  61. Benito A, Silva M, Grillot D, Nuñez G, Fernádez-Luna JL.  Apoptosis induced by erythroid differentiation of human erythroleukemia cell lines is inhibited by Bcl-xL.  Blood.  11:3837-3843 (1996).
  62. Grillot DAM, Merino R, Pena JC, Fanslow WC, Finkelman FD, Thompson CB, Nuñez G.  Bcl-x exhibits regulated expression during B Cell development and activation and modulates lymphocyte survival in transgenic mice.  J Exp Med.  183:381-391 (1996).
  63. Middleton G, Nuñez G, Davies A.  Bax promotes neuronal survival and antagonizes the survival effects of neurotrophic factors.  Development.  122:695-701 (1996).
  64. López-Hoyos M, Carrió R, Merino R, Buelta L, Izui S, Nuñez G, Merino J.  Constitutive expression of Bcl-2 in B cells causes a lethal form of lupus-like autoimmune disease after induction of neonatal tolerance to H-2b alloantigens.  J Exp Med.  183:2523-2531 (1996).
  65. Silva M, Grillot, D, Benito A, Richard C, Nuñez G, Fernandez-Luna JL.  Erythropoietin promotes erythroid progenitor survival by repressing apoptosis through Bcl-xL and Bcl-2.  Blood.  88:1576-1582 (1996).
  66. Simonian, PL, Grillot DAM, Merino R, Nuñez G.  Bax can antagonize Bcl-xL during etoposide and cisplatin induced cell death independently of its heterodimerization with Bcl-xL.  J Biol Chem.  271:22764-22773 (1996).
  67. Foreman KE, Clarke MF, Wrone-Smith T, Boise LH, Thompson CB, Polverini PJ, Apel IJ, Simonian PL, Nuñez G, Nickoloff BJ.  Kaposi’s sarcoma tumor cells preferentially express Bcl-xL and undergo apoptosis when induced to overexpress the Bcl-xL inhibitor Bcl-xS.  Am J Pathol.  149:795-803 (1996).
  68. Gibson LF, Piktel D, Narayanan R, Nuñez G, Landreth KS.  Stromal cells regulate Bcl-2 and bax expression in pro-B cells.  Exp Hematol.  24:628-637 (1996).
  69. Carrió R, Lopez-Hoyos M, Jimeno J, Benedict MA, Merino R, Benito A, Fernandez‑Luna JL, Nuñez G, Garcia-Perrero JA, Merino J.  A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death.  Am J Pathol.  149:2133-2142 (1996).
  70. Heermeier K, Benedict M, Li M, Furth P, Nuñez G, Henninghausen L.  BAX and Bcl‑XS are induced at the onset of apoptosis in involuting mammary epithelial cells.  Mech Dev.  56:197-207 (1996).
  71. Dole MG, Clarke MF, Holman P, Benedict M, Lu J, Jasty, R, Eipers P, Thompson CB, Rode C, Bloch C, Nuñez G, Castle VP.  Bcl-xs enhances adenoviral vector-induced apoptosis in neuroblastoma cells.  Cancer Res.  56:5734-5740 (1996).
  72. Ray, S, Bullock G, Nuñez G, Tang C, Ibrado AM, Huang Y, Bhalla K.  Enforced expression of Bcl-xS induces differentiation and sensitizes chronic myelogenous leukemia-blast crisis K562 cells to 1-b-D-arabinofuranosylcytosine-mediated differentiation and apoptosis.  Cell Growth Differ.  7:1617-1623 (1996).
  73. Simonian PL, Grillot DAM, Nuñez G.  Bax homodimerization is not required for Bax to accelerate chemotherapy induced cell death.  J Biol Chem.  271:32073-32077 (1996).
  74. Silva M, Grillot D, Benito A, Richard C, Nuñez G, Fernandez-Luna JL.  Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-xL and Bcl-2.  Blood.  88:1576-1582 (1996).
  75. Wu, D, Wallen HD, Nuñez G.  Interaction and regulation of subcellular localization of CED-4 by CED-9.  Science.  275:1126-1128 (1997).
  76. Mitra RS, Wrone-Smith T, Simonian P, Foreman KE, Nuñez G, Nickoloff BJ.  Apoptosis in keratinocytes is not dependent on induction of differentiation.  Lab Invest.  76:99-107 (1997).
  77. Inohara N, Ding D, Chen S, Nuñez G.  harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-xL.  EMBO J.  16:1686-1694 (1997).
  78. Grillot DAM, González-García, Ekhterae D, Linda Duan, Inohara N, Ohta S, Seldin MF, Nuñez G.  Genomic organization, promoter region analysis and chromosome localization of the mouse Bcl-x gene.  J Immunol.  158:4750-4757 (1997).
  79. Bojes HK, Datta K, Xu J, Chin A, Simonian P, Nuñez  G, Kehrer JP.  Bxl-ZL overexpression attentuates glutathione depletion in FL 5.12 cells following interleukin-3 withdrawal.  Biochemistry.  325:15:315-319 (1997).
  80. Simonian PL, Grillot DAM, Nuñez G.  Bcl-2 and Bcl-xL can differentially block chemotherapy induced cell death.  Blood.  90:1208-1216 (1997).
  81. Wu D, Wallen, HD, Inohara N, Nuñez G.  Interaction and regulation of the C. Elegans death protease CED-3 by CED-4 and CED-9.  J Biol Chem.  274:21449-21454 (1997).
  82. Simonian PL, Grillot DAM, Nuñez G.  Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-xL and Bcl-2.  Oncogene.  15:1871-1875 (1997).
  83. Inohara N, Koseki T, Hu Y, Chen S, Nuñez G.  CLARP, a novel DED-containing protein interacts with Caspase-8 and regulates apoptosis.  Proc Natl Acad Sci USA.  94:10717-10722 (1997).
  84. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nuñez G.  Interleukin-3-Induced Phosphorylation of BAD through the Protein Kinase Akt.  Science.  278:687-689 (1997).
  85. Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M, Nuñez G, Krammer PH, Peter ME, Debatin KM.  Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.  Cancer Res.  57:4956-4964 (1997).
  86. Schneider TJ, Grillot D, Foote LC, Nuñez G, Rothstein TL.  Bcl-x protects primary B cells against Fas-mediated apoptosis.  J Immunol.  159:4834-4839 (1997).
  87. Petschner F, Zimmerman C, Strasser A, Grillot D, Nuñez G, Pircher H.  Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced peripheral T cell deletion but does not influence memory T cell survival.  Eur J Immunol.  28:560-569 (1998).
  88. Akifusa S, Ohguchi M, Koseki T, Nara K, Semba I, Yamato K, Okahashi N, Merino R, Nuñez G, Hanada N, Takehara T, Nishihara T.  Increase in bcl-2 level promted by CD40 ligation correlates with inhibition of B-cell apoptosis induced by vacuolar type H+‑ATPase inhibitor.  Exp Cell Res.  238:82-89 (1998).
  89. Solvason N, Wu W, Kabra N, Lund-Johansen F, Grazia-Roncarolo M, Behren T, Grillot D, Nuñez G, Lees E, Howard M.  Transgene expression of bcl-xL permits anti-immunoglobulun (Ig)-induced proliferation of xid B cells.  J Exp Med.  187:1081-1091 (1998).
  90. Stoll S, Benedict M, Mitra R, Hiniker A, Elder JT, Nuñez G.  EGF receptor signaling inhibits keratinocyte apoptosis:  evidence for mediation by bcl-xL.  Oncogene.  16:1493-1501 (1998).
  91. Inohara N, Ekhterae D, Garcia I, Carrio R, Merino J, Merry A, Chen S, Nuñez G.  Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL.  J Biol Chem.  273:8705-8710 (1998).
  92. Hu Y, Benedict M, Wu D, Inohara N, Nuñez G.  Bcl-xL interacts with Apaf-1 and inhibits Apaf-1-dependent Caspase-9 activation.  Proc Natl Acad Sci USA.  95:4386-4391 (1998).
  93. Koseki T, Inohara N, Chen S, Nuñez G.  ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.  Proc Natl Acad Sci USA.  95:5156-5160 (1998).
  94. Inohara N, del Peso L, Koseki T, Chen S, Nuñez G.  RICK:  a novel protein kinase containing a caspase recruting domain interacts with CLARP and regulates CD95/Fas/Apo-1-mediated apoptosis.  J Biol Chem.  273:12296-12300 (1998).
  95. Inohara N, Koseki T, Chen S, Wu X, Nuñez G.  CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.  EMBO J.  17:2526-2533 (1998).
  96. Lam M, Bhat MB, Nuñez G, Ma J, Distelhorst CW.  Regulation of Bcl-xL channel activity by calcium.  J Biol Chem.  273:17307-17310 (1998).
  97. Packham G, White EL, Eischen CM, Yang H, Parganas E, Ihle JN, Grillot DAM, Zambetti GP, Nuñez G, Cleveland JL.  Selective regulation of Bcl-xL by a Jak kinsae-dependent pathway is bypassed in murine hematopoietic malignancies.  Genes Dev.  12:2475-2487 (1998).
  98. Han J, Wallen H, Nuñez G, White E.  E1B 19K interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis.  Mol Cell Biol.  18:6052-6062 (1998).
  99. Tamatani M, Ogawa S, Nuñez G, Tohyama M.  Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitic oxide.  Cell Death Diff.  5:911-918 (1998).
  100. Liu JR, Fletcher B, Page C, Hu C, Nuñez G, Baker V.  Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis.  Gynecol Oncol.  70:398-403 (1998).
  101. Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nuñez G.  Diva, a Bcl-2 homologue that directly binds to Apaf-1 and induces BH-3-independent cell death.  J Biol Chem.  273:32479-32486 (1998).
  102. Hu Y, Ding L, Spencer DM, Nuñez G.  WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation.  J Biol Chem.  273:33489-33494 (1998).
  103. del Peso L, Gonzalez VM, Nuñez G.  Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation.  J Biol Chem.  273:33495-334500 (1998).
  104. Lucas R, Garcia I, Donati YR, Hribar M, Mandriota SJ, Giroud C, Buurman WA, Fransen L, Suter PM, Nuñez G, Pepper MS, Grau GE.  Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells.  Eur J Immunol.  28:3577-3586 (1998).
  105. Inohara N, Koseki T, Chen S, Benedict MA, Nuñez G.  Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD.  J Biol Chem.  274:270-274 (1999).
  106. Wu D, Hu Y, Chen P-J, Chen S, Nuñez G*, Ellis RE*.  C. elegans MAC-1, and essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.  Development.  126:2021-2031 (1999).  *joint senior authors
  107. Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottinger MO, Nabel GJ, Nuñez G.  CIPER:  A novel NF-kappaB-activating protein containing a caspase-recruitment domain with homology to herpes virus-2 protein E10.  J Biol Chem.  274:9955-9961 (1999).
  108. Inohara N, Koseki N, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nuñez G.  Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor kB.  J Biol Chem.  274:14560-14567 (1999).
  109. Tang ED, Nuñez G, Barr FG, Guan KL.  Negative regulation of the forkhead transcription factor FKHR by Akt.  J Biol Chem.  274:16741-16746 (1999).
  110. Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Mocinski L, Nuñez G, Dalton WS, Jove R.  Interleukin 6-dependent stat3 signaling induces bcl-x gene expression and confers resistance to apoptosis in human myeloma tumor cells.  Immunity.  10:105-115 (1999).
  111. Hu Y, Benedict MA, Ding L, Nuñez G.  Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.  EMBO J.  18:3586-3595 (1999).
  112. Silva M, Benito A, Sanz C, Prosper F, Ekhterae D, Nuñez G, Fernandez-Luna JL.  Erythropoietin can induce the expression of bcl-xL through Stat5 in erythropoietin-dependent progenitor cell lines.  J Biol Chem.  274:22165-22173 (1999).
  113. Inohara N, Nuñez G.  Genes with homology to DFF/CIDEs found in Drosophila melanogaster.  Cell Death Diff.  6:823-824 (1999).
  114. Tsukahara T, Kannagi M, Ohashi T, Kato H, Arai M, Nuñez G, Iwanaga Y, Yamamoto N, Ohtani K, Nakamura M, Fujii M.  Induction of Bcl-xL expression by human T-cell leukemia virus type 1 tax through NF-kB in apoptosis-resistant T-cell transfectants with tax.  J Virol.  73:7981-7987 (1999).
  115. del Peso L, Gonzalez VM, Hernandez R, Barr FG, Nuñez G.  Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.  Oncogene.  18:7328-7333 (1999).
  116. Ekhterae D, Lin Z, Brosius FC, Núñez G.  ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells.  Circ Res.  85:e70-e77 (1999).
  117. Igaki T, Kanuka H, Inohara N, Sawamoto K, Nuñez G, Okano H, Miura Masayuki.  Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.  Proc Natl Acad Sci USA. 97:662-667 (2000).
  118. NicAmhloaibh R, Heenan K, Cleary O, Touhey S, O’Loughlin C, Nuñez G, Clynes M.  Altered expression of Bcl-2 family mRNAs affect chemoresistance in a low-level multi-drug resistant variant of a human lung carcinoma cell line overexpressing mdr-1mRNA.  Int J Cancer.  82:368-376 (1999).
  119. Wells AD, Li XC, Li Y, Walsh M, Zheng XX, Wu Z, Nuñez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA.  Requirement for T cell apoptosis in the induction of peripheral transplantation tolerance.  Nature Med.  5:1303-1307 (1999).
  120. Page C, Lin HJ, Jin Y, Castle VP, Nuñez G, Huang M, Lin J.  Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.  Anticancer Res. 20:407-16, (2000)
  121. Liu R, Page C, Beidler DR, Wicha MS, Núñez G. Overexpression of Bcl-xL promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model.  Am J Pathol. 155:1861-1867. (1999).
  122. Sanz C, Benito A, Inohara N, Ekhterae D, Nuñez G, Fernandez-Luna JL.  Specific and rapid induction of pro-apoptotic Hrk after growth factor withdrawal in hematopoietic progenitor cells.  Blood. . 95:2742-72751 (2000).
  123. Benedict MA, Hu Y, Inohara N, Nuñez G.  Expression and functional analysis of Apaf-1 isoforms. Extra WD-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9.  J Biol Chem.  275:8461-8468 (2000).
  124. Inohara N, Nuñez G: Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 7:509-10 (2000).
  125. del Peso L, Gonzalez VM, Inohara N, Ellis RE, Nuñez G: Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in caenorhabditis elegans. J Biol Chem. 275:27205-11 (2000).
  126. Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Nuñez G: An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 275:27823-31 (2000).
  127. Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G.: Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides. J Biol Chem. 276:2551-2554 (2001).
  128. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nuñez G.: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NFkappaB. J Biol Chem. 276:4812-4818 (2001).
  129. Nickerson K, Sisk TJ, Inohara N, Yee CS, Kennell J, Cho MC, Yannie PJ, Nuñez G, Chang CH. Dendritic cell specific CIITA contains a caspase-recruitment domain that confers potent transactivation activity. J. Biol. Chem 276:19089-93 (2001).
  130. Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nuñez G:  Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma,cooperate in a novel NF-kappaB signaling pathway.  J. Biol. Chem 276:19012-19019 (2001).
  131. Hernandez-Alcoceba R, Pihalja M, Nuñez G, Clarke MF:  Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells.  Cancer Gene Therapy 8:298-07 (2001).
  132. Kulik G, Carson JP, Vomastek T, Overman K, Gooch BD, Srinivasula S, Alnemri E, Nuñez G, Weber MJ:  Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells.  Cancer Res 61:2713-9 (2001).
  133. Mitra RS, Benedict MA , Qian D,  Foreman KE ,  Ekhterae D, Nickoloff BJ and Nuñez G.  Killing of sarcoma cells by pro-apoptotic Bcl-XS:  Role of the BH3 domain and regulation by Bcl-XL.  Neoplasia 23:437-445 (2001).
  134. Yasunori O, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar J-P, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nuñez G* and Cho JH* (*joint senior authors). A frameshift mutation in Nod2 associated with susceptibility to Crohn's disease.  Nature 411:603-606 (2001).
  135.  McAllister-Lucas LM, Inohara N,  Lucas PC,  Ruland J,  Benito A,  Li Q,  Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW and Núñez G. Bimp1, a MAGUK Family Member Linking PKC Activation to Bcl10-Mediated NF-kB Induction.  J Biol Chem  276: 30589-30597 (2001).
  136. Nair RP, Stuart P, Ogura Y, Inohaha N, Chia NVC, Young L, Henseler T, Jenisch S, Christophers E, Voorhees JJ, Nuñez G, Elder JT.  Lack of association between NOD2 3020InsC frameshift mutation and psoriasis.  J Invest Dermatol 117:1671-1672 (2001).
  137. Lin J, Page C, Jin X, Sethi AO, Patel R, Nuñez G.  Suppression activity of pro-apoptotic gene products in cancer cells, a potential application for cancer gene therapy.  Anticancer Res 21:831-839 (2001).
  1. Kobayashi K, Inohara N, Hernandez LD, Galan JE, Nuñez G, Janeway C, Medzhitov R, Flavell RA.  RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.  Nature 416:194-199 (2002).
  2. Liu JR, Opipari AW, Tan L, Jiang Y, Zhang Y, Tang H, Nuñez G.  Dysfunctional apoptosome activation in ovarian cancer:  Implications for chemoresistance.  Cancer Res; 62:924-931 (2002).
  3. Nor JE, Hu Y, Song W, Spencer DM, Nuñez G.  Ablation of microvessels in vivo upon dimerization of iCaspase-9.  Gene Therapy 9:444-451 (2002).
  4. Inohara N, Nuñez G.  A conserved domain in MD-2 related protein family involved in innate immunity and lipid metabolism.  Trends Biochem Sci  27:219-221 (2002)
  5. Muto A, Ruland J, McAllister-Lucas LM, Lucas PC, Yamaoka S, Chen FF, Lin A, Mak TW, Nuñez, G, Inohara, N  PKK mediates Bcl10-independent NF-kappa B activation induced by phorbol ester. J Biol Chem.; 277:31871-31876 (2002).
  6. Gutierrez O,. Pipaon C, Inohara N, Fontalba A, Ogura Y, Prosper F, Nuñez G, Fernandez-Luna JL. Induction of Nod2 in myelomonocytic and intestinal Ephithelial cellsvia nuclear factor-kB activiation. J Biol Chem   227:41701-41705 (2002).
  7. Wang D, You Y, Case SM, McAllister Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, LinX. A requirement for CARMA1 in TCR-induced NF-kappaB activation. Nat Immunol. 3:830-835 (2002).
  8. Inoue N, Tamura K, Kinouchi Y, Fukuda Y, Takahashi S, Ogura Y, Inohara N, Nuñez G, Kishi Y, Koike Y, Shimosegawa T, Shimoyama T, Hibi T. Lack of common NOD2 variants in Japanese patients with Crohn’s disease. Gastroenterology. 123:86-91(2002).
  9. Wang X, Kuivaniemi H, Bonavita G, Mutkus L, Mau U, Blau E, Inohara N, Nuñez G, Tromp G, Williams CJ. CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy. Arthritis Rheum 46:3041-3045(2002).
  10. Masumoto J, Zhou W, Chen FF, Su F, Kuwada JY, Hidaka E, Katsuyama T, Sagara J, Taniguchi S, Ngo-Hazelett P, Postlethwait JH, Nuñez G, Inohara N. Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal Arch development. J Biol Chem 278:4268-4276 (2003).
  11. Bonen DK, Ogura Y, Nicolae DL, Inohara N, Saab L, Tanabe T, Chen FF, Foster SJ, Duerr RH, Brant SR, Cho JH, Nuñez G. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 124:140-146 (2003).
  12. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nuñez G. Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease. J Biol Chem 278:5509-55012 (2003).
  13. Dowds TA, Maumoto J, Chen F, Ogura Y, Inohara N, Nuñez G.  Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.  Biochemical and Biophysical Research Communications 302:575–580 (2003).
  14. Masumoto J, Dowds TA, Schaner P, Chen F, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio D, Nuñez G, Inohara N.  ASC Is an Activating Adaptor for NF-kB and Caspase-8-Dependent Apoptosis.  Biochem Biophys Res Commun 303:69-73, (2003)
  15. Ogura Y, Saab L, Chen F, Benito A, Inohara N, Nuñez G.  Genetic Variation and Activity of Mouse Nod2, a Susceptibility Gene for Crohn's Disease.  Genomics 81:369-377, (2003)
  16. Merino J, Diez MA, Muniz M, Buelta L, Nuñez G,  Lopez-Hoyos M, Merino R.  Inhibition of B-cell death does not restore T-cell-dependent immune responses in CD40-deficient mice.  Immunology 109:504-509, (2003)
  17. Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nuñez G , Keshav S.  Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology, 125:47-57, (2003)
  18. Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Nuñez G , Inohara N.  An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.  Nat Immunol, 4:702-707, (2003)
  19. Tang ED, Inohara N, Wang CY, Nuñez G , Guan KL.  Roles for homotypic interactions and transautophosphorylation in IKKbeta activation.  J Biol Chem. 278: 38566-385670, (2003)
  20. Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nuñez G .  Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.  Gut. 52:1591-1597 (2003)
  21. Imaizumi K, Benito A, Kiryu-Seo S, Gonzalez V, Inohara N, Leiberman AP, Kiyama H, Nuñez G.  Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.  J Neuroscience. 24:3721-3725 (2004).
  22. Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N, Nuñez G .  Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.  EMBO J. 7; 23:1587-1597 (2004).
  23. Dowds TA, Masumoto J, Zhu L, Inohara N, Nuñez G.  Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.  J Biol Chem. 279:21924-21928 (2004).
  24. Swanson PJ, Kuslak SL, Fang W, Tze L, Gaffney P, Selby S, Hippen KL, Nuñez G , Sidman CL, Behrens TW.  Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc.  J Immunol. 172:6684-6691 (2004).
  25. Lucas PC, Mc-Allister-Lucas L, Nuñez G.  NF-kappaB signaling in lymphocytes: a new cast of characters.  J Cell Sci. 117:31-39 (2004).
  26. Chamaillard M, Inohara N, Nuñez G . Battling enteroinvasive bacteria: Nod1 comes to the rescue. Trends Microbiol.  12:529-32 (2004).
  27. Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G*, Flavell RA*. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 307:731-4 (2005). (*share senior authorship).
  28. Song W, Sun Q, Dong Z, Spencer DM, Nuñez G, Nor JE. Antiangiogenic gene therapy: disruption of neovascular networks mediated by inducible caspase-9 delivered with a transcriptionally targeted adenoviral vector. Gene Ther.  4:320-9 (2005).
  29. Suzuki T, Nakanishi K, Tsutsui H, Iwai H, Akira S, Inohara N, Chamaillard M, Nuñez G, Sasakawa C.  A novel caspase-1/Toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J Biol Chem.  280: 14042-14050 (2005).
  30. Hysi P, Kabesch M, Moffatt MF, Schedel M, Carr D, Zhang Y, Boardman B, von Mutius E, Weiland SK, Leupold W, Fritzsch C, Klopp N, Musk AW, James A, Nuñez G, Inohara N, Cookson WO.  NOD1 variation, Immunoglobulin E, and asthma.  Hum Mol Genet.  14: 935-941 (2005).
  31. McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lecine P, Borg JP, Nuñez G. A role for erbin in the regulation of NOD2-dependent NF-kappa B signaling. J Biol Chem.  280:40301-40309. (2005).
  32. Karl E, Warner K, Zeitlin B, Kaneko T, Wurtzel L, Jin T, Chang J, Wang S, Wang CY, Strieter RM, Nuñez G, Polverini PJ, Nor JE.  Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines.  Cancer Res.  65:5063-5069 (2005).
  33. Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y,  Kawasaki A, Foster SJ, Horie Y, Mak TW, Núñez G,  Chinnaiyan AM, Fukase K,  Inohara N. Nod1 acts as an intracellular receptor to mediate chemokine secretion and neutrophil recruitment in vivo. J. Exp. Med. 23:203-213 (2006)
  34. Kanneganti T-D, Özören N, Body-Malapel M, Amer A, Park J-P, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J,  Coyle A, Grant EP, Akira S,  Núñez G. Bacterial RNA and Small Antiviral Compounds Activate Caspase-1 Through Cryopyrin/Nalp3. Nature 440:233-236 (2006).  
  35. Özören N, Masumoto J, Franchi L, Kanneganti T-D, Body-Malapel M, Ertürk I*, Jagirdar R, Zhu L, Inohara N, Bertin J, Coyle A, Grant EP, and Núñez G. Distinct Roles of TLR2 and the Adaptor ASC in IL-1b/IL-18 Secretion in response to Listeria monocytogenes. J. Immunol 176:4337-4342 (2006).
  36. Nishito Y, Hasegawa M, Inohara N and Núñez G.  MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem J.  396:411-417. (2006).
  37. Boughan PK, Argent RH, Body-Malapel M, Park JH, Ewings KE, Bowie AG, Ong SJ, Cook SJ, Sorensen OE, Manzo BA, Klein NJ, Núñez G., Atherton JC, Bajaj-Elliott M. Nucleotide-binding oligomerisation domain-1 (NOD-1) and epidermal growth factor receptor (EGFR): Critical regulators of beta -defensins during helicobacter pylori infection.  J Biol Chem.  281:11637-11648 (2006).
  38. Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
    Nat Immunol. 7:576-582 (2006).
  39. Tanabe T, Ishige I, Suzuki Y, Aita Y, Furukawa A, Ishige Y, Uchida K, Suzuki T, Takemura T, Ikushima S, Oritsu M, Yokoyama T, Fujimoto Y, Fukase K, Inohara N, Núñez G, Eishi Y.  Sarcoidosis and NOD1 variation with impaired recognition intracellular Propionibacterium acnes.  Biochim Biophys Acta, 9: 794-801 (2006).
  40. Hasegawa M, Yang K, Hashimoto M, Park JH, Fujimoto Y, Núñez G, Fukase K, Inohara N.  Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.  J Biol Chem. 281(39): 29054-29063 (2006). 
  41. Detmar J, Rabaglino T, Taniuchi Y, Oh J, Acton BM, Benito A, Núñez G, Jurisicova A. Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax.  Apoptosis. 8:1413-1425 (2006).
  42. Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozoren N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Núñez G. Regulation of Legionella phagosome maturation and infection through flagellin and host IPAF. J. Biol. Chem.  281:35217-35223 (2006).
  43. Kanneganti TD, Body-Malapel M, Amer A, Park J,H., Whitfield J, Taraporewals Z, Miller, D Patton J.T., Inohara N, Núñez G. Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.   J. Biol. Chem.  mediates angiotensin II-responsive inflammatory signaling in noimmune cells.  Proc Natl Acad Sci USA 104:139-144 (2007).
  44. Park JH, Kim YG, McDonald C, Kanneganti TD, Hasegawa M, Body-Malapel M,  Inohara I, and Núñez G.  RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not Toll-like receptors.  Journal of Immunology 178(4):2380-2386 (2007).  PMID: 17277144.
  45. Coussens NP, Mowers JC, McDonald C, Núñez G, Ramaswamy S. Crystal structure of the Nod1 caspase activation and recruitment domain.  Biochem Biophys Res Commun. 353(1):1-5 (2007).  PMCID: PMC1821002.
  46. Lecine P, Esmiol S, Metais JY, Nicoletti C, Nourry C, McDonald C, Núñez G, Hugot JP, Borg JP, Ollendorff V.  The NOD2-RICK complex signals from the plasma membrane.   The Journal of Biological Chemistry 282(20):15197-15207 (2007).  PMID: 17355968.
  47. Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E, Núñez G, Fukase K, Inohara N.  A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.  The Journal of Biological Chemistry 282(16):11757-11764 (2007).  PMID: 17322292.
  48. Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Núñez G. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.  Immunity 26(4):433-443 (2007).  PMID: 17433728.
  49. Lamkanfi M, Amer A, Kanneganti TD, Munoz-Planillo R, Chen G, Vandenabeele P, Fortier A, Gros P, Núñez G. The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.  Journal of Immunology 178(12):8022-8027 (2007).  PMID: 17548639.
  50. Franchi L, Kanneganti TD, Dubyak GR, Núñez G. Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.  The Journal of Biological Chemistry 282(26):18810-18818 (2007).  PMID: 17491021.
  51. Park JH, Kim YG, Shaw M, Kanneganti TD, Fujimoto Y, Fukase K, Inohara N, Núñez G. Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.  Journal of Immunology 179(1): 514-521 (2007).  PMID: 17579072.
  52. Karl E, Zhang Z, Dong Z, Neiva KG, Soengas MS, Koch AE, Polverini PJ, Núñez G, Nor JE. Unidirectional crosstalk between Bcl-xL and Bcl-2 enhances the angiogenic phenotype of endothelial cells.  Cell Death and Differentiation 14(9):1657-1666 (2007).  PMID: 17572663.
  53. Qu Y, Franchi L, Núñez G, Dubyak GR.  Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages.  Journal of Immunology 179(3):1913-1925 (2007).  PMID: 17641058.
  54. Zilbauer M, Dorrell N, Elmi A, Lindley KJ, Schuller S, Jones HE, Klein NJ, Núñez G, Wren BW, Bajaj-Elliott M. A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni.  Cellular Microbiology 9(10):2404-2416 (2007).  PMID: 17521327.
  55. Dong Z, Zeitlin BD, Song W, Sun Q, Karl E, Spencer Dm, Jain HV, Jackson T, Núñez G, Nor JE.  Level of endothelial cell apoptosis required for a significant decrease in microvessel density.  Experimental Cell Research 313(16):3645-3657 (2007).  PMCID: PMC2080879.
  56. Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Núñez G.  Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathogens 3(8):e111 (2007).  PMCID: PMC1941748.
  57. Franchi L, Stoolman J, Kanneganti TD, Verma A, Ramphal R, Núñez G.  Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation.   European Journal of Immunology 37(11):3030-3039 (2007).  PMID: 17935074.
  58. Jurisicova A, Taniuchi A, Li H, Shang Y, Antenos M, Detmar J, Xu J, Matikainen T, Benito Hernandez A, Núñez G, Casper RF.  Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri.  The Journal of Clinical Investigation 117(12):3971-3978 (2007).  PMCID: PMC2082141.
  59. Hutchens M, Luker KE, Sottile P, Sonstein J, Lukacs NW, Núñez G, Curtis JL, Luker GD. TLR3 increases disease morbidity and mortality from vaccinia infection.  Journal of Immunology 180(1):483-491 (2008).  PMID: 18097050.
  60. Marina-García N,  Franchi L,  Kim Y-G, Miller D,  McDonald C, Boons G-H, Núñez G. Pannexin-1-mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2.  Journal of Immunology 180(6):4050-4057 (2008).  PMID: 18322214.
  61. Kim JY, Omori E, Matsumoto K, Núñez G, Ninomiya-Tsuji J. TAK1 is a central mediator of NOD2 signaling in epidermal cells.  The Journal of Biological Chemistry 283(1):137-144 (2008).  PMCID: PMC2288618.
  62. Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N.  A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kB activation. The EMBO Journal 27(2):373-383 (2008).  PMCID: PMC2234345.
  63. Kim YG, Park J-P, Shaw MH, Franchi L, Inohara N and Núñez G.  The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.  Immunity 28(2): 246-257 (2008).  PMID: 18261938.
  64. Song W, Dong Z, Jin T, Mantellini MG, Núñez G, Nör JE.  Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.  Cancer Gene Therapy 15(10):667-675 (2008).  PMCID: PMC2665693.
  65. Kim YG, Park, JH, Daignault S, Fukase K, Núñez G. Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages.  Journal of Immunology 181(6):4340-4346 (2008).  PMCID: PMC2830743.
  66. Lamkanfi M, Kanneganti TD, Van Damme P, Vanden Berghe T, Vanoverberghe I, Vanderkerckhove J, Vandenabeele P, Gevaert K, Núñez G.  Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.  Molecular & Cellular Proteomics 7(12):2350-2363 (2008).  PMCID: PMC2596343.
  67. Hutchens MA, Luker KE, Sonstein J, Núñez G, Curtis JL, Luker GD.  Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection.  PLoS Pathogens 4(9):e1000153 (2008).  PMCID: PMC2529451.
  68. Franchi L, Núñez G. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.  European Journal of Immunology 38(8):2085-2089 (2008).  PMCID: PMC2759997.
  69. Moreira LO, El Kasmi KC, Smith AM, Finkelstein D, Fillon S, Kim YG, Núñez G, Tuomanen E, Murray PJ.  The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls.  Cellular Microbiology 10(10):2067-2077 (2008).  PMID: 18549453.
  70. Eigenbrod T, Park JH, Harder J, Iwakura Y, Núñez G.  Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.  Journal of Immunology 181(12):8194-8198 (2008).  PMCID: PMC2762646.
  71. Chen GY, Shaw MH, Redondo G, Núñez G.  The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis.  Cancer Research 68(24):10060-10067 (2008).  PMCID: PMC2804847.
  72. Park JH, Kim YG, Núñez G. RICK promotes inflammation and lethality after gram-negative bacterial infection in mice stimulated with lipopolysaccharide. Infection and Immunity 77(4):1569-1578 (2009).  PMCID: PMC2663158.
  73. Saha S, Qi J, Wang S, Wang M, Li X, Kim YG, Núñez G, Gupta D, Dziarski R. PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host & Microbe 5(2):137-150 (2009).  PMCID: PMC2671207.
  74. Sanders CJ, Franchi L, Yarovinsky F, Uematsu S, Akira S, Núñez G, Gewirtz AT. Induction of adaptive immunity by flagellin does not require robust activation of innate immunity.  European Journal of Immunology 39(2):359-371 (2009).  PMCID: PMC2734905.
  75. Marina-García N, Franchi L, Kim YG, Hu Y, Smith DE, Boons GJ, Núñez G. Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation.  Journal of Immunology 182(7):4321-4327 (2009).  PMCID: PMC2753867.
  76. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G.  Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.  Cell Death & Differentiation 16(8):1093-1107 (2009).  PMCID: PMC2757140. 
  77. Nakamura Y, Kambe N, Saito M, Nishikomori R, Kim YG, Murakami M, Núñez G, Matsue H.  Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.  The Journal of Experimental Medicine 206(5):1037-1046 (2009).  PMCID: PMC2715029.
  78. Qu Y, Ramachandra L, Mohr S, Franchi L, Harding CV, Núñez G,  Dubyak GR.  P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1.  Journal of Immunology 182(8):5052-5062 (2009).  PMCID: PMC2768485. 
  79. Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, Ryffel B, Akira S, Langella P, Nùñez G, Sirard JC, Iovanna J, Simonet M, Chamaillard M.  Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.  Gut 58(6):771-776 (2009).  PMID: 19174417. 
  80. Harder J, Núñez G.  Functional expression of the intracellular pattern recognition receptor NOD1 in human keratinocytes.   The Journal of Investigative Dermatology 129(5):1299-1302 (2009).  PMID: 19122645.
  81. Ozoren N, Inohara N, Núñez G.  A putative role for human BFK in DNA damage-induced apoptosis.  Biotechnology Journal 4(7):1046-1054 (2009).  PMID: 19557800.
  82. Franchi L, Eigenbrod T, Nuñez G.  Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.  Journal of Immunology 183(2):792-796 (2009).  PMCID: PMC2754237.  
  83. Chu J, Thomas LM, Watkins SC, Franchi L, Nuñez G, Salter RD.  Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner.  Journal of Leukocyte Biology 86(5):1227-1238 (2009).  PMCID: PMC2774880.
  84. Loving CL, Osorio M, Kim YG, Núñez G, Hughes MA, Merkel TJ.  Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure.  Infection & Immunity 77(10):4529-4537 (2009).  PMCID: PMC2747953.
  85. Muñoz-Planillo R, Franchi L, Miller LS, Nuñez G.  A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.  Journal of Immunology 183(6):3942-3948 (2009).   PMCID: PMC2762867.
  86. Shaw MH, Reimer T, Sánchez-Valdepeñas C, Warner N, Kim YG, Fresno M, Nuñez G. T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.  Nature Immunology 10(12):1267-1274 (2009).  PMCID: PMC2803073.
  87. Harder J, Franchi L, Muñoz-Planillo R, Park JH, Reimer T, Nuñez G.  Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor.  Journal of Immunology 183(9):5823-5829 (2009).  PMCID: PMC2765568.
  88. Franchi L,  Chen G, Marina-Garcia N, Abe A, Qu Y, Bao S, Shayman JA, Turk J, Dubyak GR, Nuñez G.  Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.  Journal of Innate Immunity 1(6):607-617 (2009).  PMCID: PMC2768374.
  89. Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhaes JG, Yuan L, Soares F, Chea E, Le Bouhirs L, Boneca IG, Allaoui A, Jones NL, Nuñez G, Girardin SE, Philpott DJ. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.  Nature Immunology 11(1):55-62 (2010).  PMID: 19898471.
  90. Reimer T, Shaw MH, Franchi L, Coban C, Ishii KJ, Akira S, Horii T, Rodriguez A, Nuñez G. Experimental cererbal malaria progresses independently of the Nlrp3 inflammasome.  European Journal of Immunology 40(3):764-769 (2010).  PMCID: PMC2837133.
  91. Hasegawa M, Osaka T, Tawaratsumida K, Yamazaki T, Tada H, Chen GY, Tsuneda S, Nuñez G, Inohara N.  Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.  Infection and Immunity 78(2):639-650 (2010). PMCID: PMC2812188.
  92. Kamarajan P, Bunek J, Lin Y, Nuñez G, Kapila YL.  Receptor-interacting protein shuttles between cell death and survival signaling pathways.  Molecular Biology of the Cell 21(3):481-488 (2010).  PMCID: PMC2814792.
  93. Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nuñez G, Ishii KJ, Akira S.  Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.  Cell Host & Microbe 7(1):50-61 (2010).  PMID: 20114028.
  94. Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Nuñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A.  Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.  Journal of Immunology 184(7):3326-3330 (2010).  PMID: 20200276.
  95. Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Nuñez G, Suzuki T.  Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.  Journal of Immunology 184(9):5287-5297 (2010).  PMID: 20348425.
  96. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.  NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.  Nature 464(7293):1357-1361 (2010).  PMCID: PMC2946640.  
  97. Lukacs NW, Smit JJ, Mukherjee S, Morris SB, Núñez G, Lindell DM.  Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation. Journal of Immunology 185(4):2231-2239 (2010).  PMCID: PMC3006454.  
  98. Russo HM, Wickenheiser KJ, Luo W, Ohman MK, Franchi L, Wright AP, Bodary PF,  Núñez G, Eitzman DT. P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue.  Circulation Research 107(3):388-397 (2010).  PMCID: PMC2917501.
  99. Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Núñez G, Yodoi J, Kahn SE, Lavelle EC, O’Neill LA.  Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nature Immunology 11(10):897-904 (2010).  PMCID: PMC3103663.
  100. Rastogi R, Du W, Ju D, Pirockinaite G, Liu Y, Nunez G, Samavati L. Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells. American Journal of Respiratory and Critical Care Medicine 183(4):500-510.  PMID: 20851927.
  101. Brooks MN, Rajaram MV, Azad AK, Amer AO, Valdivia-Arenas MA, Park JH, Núñez G, Schlesinger LS.  NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages.  Cellular Microbiology 13(3):402-418 (2011).  PMCID: PMC3259431.
  102. Rosenzweig HL, Galster K, Vance EE, Ensign-Lewis J, Núñez G, Davey MP, Rosenbaum JT. NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice.  Investigative Ophthalmology and Visual Science 52(7):4106-4112 (2011).  PMCID: PMC3175939.
  103. Hasegawa M, Yamazaki T, Kamada N, Tawaratsumida K, Kim YG, Nuñez G, Inohara N.  Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.  Journal of Immunology 186(8):4872-4880 (2011).  PMID: 21411735.   
  104. Chen GY, Liu M, Wang F, Bertin J, Nuñez G.  A functional role for Nlrp6 in intestinal inflammation and tumorigenesis.  Journal of Immunology 186(12):7187-7194 (2011).  PMCID: PMC3133458.
  105. Embry CA, Franchi L, Nuñez G, Mitchell TC. Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A.  Science Signaling 4(171): ra28 (2011). PMCID: PMC3249414.
  106. Rosenzweig HL, Clowers JS, Nuñez G, Rosenbaum JT, Davey MP.  Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice. Inflammation Research 60(7):705-714 (2011).   PMCID: PMC3352590. 
  107. Kim YG, Park JH, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C, Nuñez G.  Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.  Cell Host & Microbe 9(6):496-507 (2011).  PMCID: PMC3125972.
  108. Bauernfeind F, Bartok E, Rieger A, Franchi L, Nuñez G, Hornung V.  Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.  Journal of Immunology 187(2):613-617 (2011).  PMCID: PMC3131480.
  109. Kim YG, Kamada N, Shaw MH, Warner N, Chen GY, Franchi L, Nuñez G.  The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes.  Immunity 34(5):769-780 (2011).  PMCID: PMC3103637.
  110. Kim YG, Shaw MH, Warner N, Park JH, Chen F, Ogura Y, Nuñez G. Cutting edge: Crohn’s disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality.  Journal of Immunology 187(6):2849-2852 (2011).  PMCID: PMC3169738.
  111. Anand PK, Tait SW, Lamkanfi M, Amer AO, Núñez G, Pagès G, Pouysségur J, McGargill MA, Green D, Kanneganti TD.  TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated (ERK) activation.  The Journal of Biological Chemistry 286(50):42981-42991 (2011).  PMCID: PMC3234870.
  112. Joseph NM, He S, Quintana E, Kim YG, Núñez G, Morrison SJ.  Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut.  The Journal of Clinical Investigation 121(9):3998-3411 (2011). PMCID: PMC3163971. 
  113. Barthson J, Germano CM, Moore F, Maida A, Drucker DJ, Marchetti P, Gysemans C, Mathieu C, Núñez G, Jurisicova A, Eizirik DL, Gurzov EN.  Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.  The Journal of Biological Chemistry 45:39632-39643 (2011).  PMCID: PMC3234786.
  114. Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Núñez G, Samavati L. TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages.  Journal of Immunology 6:2847-2857 (2012).  PMCID: PMC3294201.
  115. Tanikawa T, Wilke CM, Kryczek I, Chen GY, Kao J, Núñez G, Zou W.  Interleukin-10 ablation promotes tumor development, growth, and metastasis. Cancer Research 2:420-429 (2012).  PMCID: PMC3261323.
  116. Galluzzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G,  Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan  J, Zhivotovsky B, Melino G, Kroemer G.  Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012.  Cell Death and Differentiation 19(1):107-120 (2012). PMCID: PMC3252826.
  117. Richmond AL, Kabi A, Homer CR, Marina-García N, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan AM, Núñez G, McDonald C. The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology 7:1483-1492.e6 (2012).  PMID: 22387394.
  118. Shaw MH, Kamada N, Kim YG, Núñez G.  Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine.  The Journal of Experimental Medicine 2:251-258 (2012).  PMCID: PMC3280878.
  119. Franchi L, Kamada N, Nakamura Y, Burberry A, Kuffa P, Suzuki S, Shaw M. H., Kim Y-G., and Núñez G.  NLRC4-driven production of IL-1b discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.  Nature Immunology 5:449-456 (2012).  PMCID: PMC3395620.
  120. Do JS, Foucras G, Kamada N, Schenk AF, Shaw M, Núñez G, Paul WE, Min B.  Both exogenous commensal and endogenous self-antigens stimulate T cell proliferation under lymphopenic conditions.  Cellular Immunology 2:117-123 (2012).  PMCID: PMC3244518.
  121. Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, Martens EC, Núñez G. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.  Science.  6086:1325-1329 (2012).  PMID: 22582016.
  122. Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J.  DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.  Cell 4:847-859 (2012).  PMCID: PMC3351582. .
  123. Eigenbrod T, Franchi L, Muñoz-Planillo R, Kirschning CJ, Freudenberg MA, Núñez G, Dalpke A.  Bacterial RNA mediates activation of Caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.  Journal of Immunology 1:328-336 (2012).   PMID: 22634614.
  124. Homer CR, Kabi A, Marina-García NI, Sreekumar A, Nesvizhskii AI, Nickerson KP, Chinnaiyan AM, Núñez G, McDonald C.  A dual role for receptor interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy.  The Journal of Biology Chemistry 30:25565-25576 (2012).   PMCID: PMC3408141.
  125. Nakamura  Y, Luigi Franchi L, Kambe N, Meng G, Strober W, Núñez G. Critical Role for Mast Cells in IL-1b-Driven Skin Inflammation Induced by an Activating Nlrp3 mutation. Immunity 1:85-95 (2012).  PMCID: PMC3411177.