Andi Cani and Yashar Niknafs Molecular and Cellular Pathology PhD graduate student, Andi Cani, BS, MS, and Postdoctoral Fellow Yashar Niknafs, PhD, were among the twelve recipients of the inaugural U-M Precision Health Scholars Award. This award provides grants supporting precision-health research to applicants whose work reflects the far-reaching potential of precision health at the University of Michigan.
Cani’s proposal focuses on the development of a pre-digital rectal exam (pre-DRE) whole urine-based, next generation sequencing assay for the early detection of prostate cancer. His research builds on that conducted in the Michigan Center for Translational Pathology (MCTP) under the leadership of Dr. Scott Tomlins and Dr. Arul Chinnaiyan. The MCTP research team discovered that the PCA3 long non-coding RNA molecule as well as an RNA molecule generated by the genomic rearrangement and fusion of two genes, TMPRSS2 and ERG, are present in more than half of all prostate cancers and can be detected in urine. Cani’s project will focus on identifying other prostate cancer biomarkers and creating an assay that can detect early-stage prostate cancer in urine without requiring the currently-prerequisite digital rectal exam.
Niknafs’ proposal will expand upon work completed by The Michigan Genomics Initiative, which profiled genetic data from over 50,000 patients at the University of Michigan and integrated these data with electronic medical record (EMR) curation to yield a Phenome-Wide Association Study (PheWAS). PheWAS is a powerful dataset that associates genetic variants with various phenotypes. While initial analyses of these data have associated many genes with various phenotypes, most functional elements implicated in these large-scale variant studies are protein-coding genes due to annotation limitations. With this award, Niknafs aims to utilize a large-scale RNA-sequencing cohort to expand the pool of potential functional elements by integrating non-coding RNA elements. Additionally, he will build a web-tool which will provide capacity to visualize and analyze the RNA-seq datasets as well as their integration with the PheWAS data.
For a full list of Precision Health Scholars Awardees, visit the Precision Health website.
ON THE COVER
Breast team reviewing a patient's slide. (From left to right) Ghassan Allo, Fellow; Laura Walters, Clinical Lecturer; Celina Kleer, Professor. See Article 2014Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Autopsy Technician draws blood while working in the Wayne County morgue. See Article 2016Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Dr. Sriram Venneti, MD, PhD and Postdoctoral Fellow, Chan Chung, PhD investigate pediatric brain cancer. See Article 2017Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Director of the Neuropathology Fellowship, Dr. Sandra Camelo-Piragua serves on the Patient and Family Advisory Council. 2018Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Residents Ashley Bradt (left) and William Perry work at a multi-headed scope in our new facility. 2019Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Dr. Kristine Konopka (right) instructing residents while using a multi-headed microscope. 2020Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Patient specimens poised for COVID-19 PCR testing. 2021Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Dr. Pantanowitz demonstrates using machine learning in analyzing slides. 2022Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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(Left to Right) Drs. Angela Wu, Laura Lamps, and Maria Westerhoff. 2023Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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Illustration representing the various machines and processing used within our labs. 2024Department Chair |
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INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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MLabs, established in 1985, functions as a portal to provide pathologists, hospitals. and other reference laboratories access to the faculty, staff and laboratories of the University of Michigan Health System’s Department of Pathology. MLabs is a recognized leader for advanced molecular diagnostic testing, helpful consultants and exceptional customer service.