Q: Should I refrigerate the sample?
No, do not refrigerate any samples.
Q: How can I access patient results directly from Care Web?
HLA typing reports are available under the recipient on CareWeb. Please be advised these are secure orders and an audit trail is maintained on all persons viewing these reports. Antibody screening results will be available on CareWeb in the very near future.
Q: When should a post-transfusion sample be collected to monitor HLA antibodies?
A sample should be drawn approximately 14 days post-transfusion.
Q: What should I do if a patient leaves the clinic without getting their blood drawn for Histocompatibility?
Notify the Histocompatibility Lab and we can send the patient a kit to have the samples drawn.
Q: How long does it take to get HLA typing results?
Molecular testing is performed to identify HLA class I and class II antigens. The turn around time is ten working days.
Q: What is HLA Typing?
HLA antigens are glycoproteins, the product of multiple, closely linked genes on a single chromosome usually inherited as an intact unit. HLA class I typing refers to the HLA-A, B, and C loci. HLA class II typing refers to the HLA-DRB1,3,4,5 and DQB1 regions. The laboratory utilizes molecular methods for defining HLA class I and class II antigens and performs HLA typing on approximately 5100 subjects per year.
Q: What is a Crossmatch?
Crossmatch analysis detects the presence of donor-reactive alloantibodies. The method used is CDC (complement dependent cytotoxicity). The crossmatch may be performed using unseparated T and B donor lymphocytes, or isolated donor T cells (detecting class I antibody), or isolated donor B cells (detecting class II antibody). Positive crossmatch results are graded from weak positive to strong positive.
Q: What is Antibody Screening?
Antibody screening identifies HLA class I and class II antibodies. The antibody screening methodologies include CDC (complement dependent cytotoxicity) and ELISA (Enzyme Linked Immunosorbent Assay) assays. Each method has advantages and is utilized in different cases. The PRA (panel reactive antibody) is calculated and antibody specificity is determined by analyzing the antibody screening data.
ON THE COVER
Breast team reviewing a patient's slide. (From left to right) Ghassan Allo, Fellow; Laura Walters, Clinical Lecturer; Celina Kleer, Professor. See Article |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Autopsy Technician draws blood while working in the Wayne County morgue. See Article |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Dr. Sriram Venneti, MD, PhD and Postdoctoral Fellow, Chan Chung, PhD investigate pediatric brain cancer. See Article |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Director of the Neuropathology Fellowship, Dr. Sandra Camelo-Piragua serves on the Patient and Family Advisory Council. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Residents Ashley Bradt (left) and William Perry work at a multi-headed scope in our new facility. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Dr. Kristine Konopka (right) instructing residents while using a multi-headed microscope. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Patient specimens poised for COVID-19 PCR testing. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Dr. Pantanowitz demonstrates using machine learning in analyzing slides. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
(Left to Right) Drs. Angela Wu, Laura Lamps, and Maria Westerhoff. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Illustration representing the various machines and processing used within our labs. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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MLabs, established in 1985, functions as a portal to provide pathologists, hospitals. and other reference laboratories access to the faculty, staff and laboratories of the University of Michigan Health System’s Department of Pathology. MLabs is a recognized leader for advanced molecular diagnostic testing, helpful consultants and exceptional customer service.