Pathology News

Team Publishes on Ewing-Like Sarcomas

By Elizabeth Walker | 26 August

Collaborative work by Dr. Grace Wang, Dr. Bryan Betz, Dr. Paul Harms, Dr. Rajiv Patel, Dr. Dafydd Thomas, Dr. Jonathan McHugh, and Dr. David Lucas has resulted in a paper published in The American Journal of Surgical Pathology. EWSR1-NFATC2 Translocation-Associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor highlights the findings of a small study indicating that, like most Ewing-like sarcomas, EWSR1-NFATC2 translocation-associated sarcomas do not respond to Ewing sarcoma therapies. The study also found that the EWRS1 gene is amplified and can serve as a marker for these tumors via FISH testing. Additionally, tumors can present with corded histology or round cell morphology and mixed morphology seems to represent tumor progression. The study was awarded best 2019 USCAP abstract by the International Society of Bone and Soft Tissue Pathology. Read more at Ingenta Connect

 
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