Dr. Ting's Mentor, Nicholas Lukacs, PhD, introducing her to the stage.Dr. Ting successfully defended her PhD thesis, Notch ligand Delta-like 4 (DII4) induced epigenetic mechanisms in regulatory T cell function during pulmonary viral infection, on February 21, 2018. Working in the laboratory of Nicholas Lukacs, PhD, Anna has studied the epigenetic regulation of T cells during Respiratory Syncytial virus (RSV) infection. RSV infects over 90% of children below two years of age and is the number one world-wide cause of hospitalization for children. In many developing countries this infection is the leading cause of death in children under five. The virus infects the lower lung, causing severe mucus secretion, airway obstruction, and a bronchiolitis. Despite its global impact, there are relatively few therapies and currently no vaccine.
Anna describes her work as “Investigating the cell fate decision mechanism in regulatory T cells during pulmonary infect.” Her dissertation investigated the role of T cells in RSV pathogenesis. Activated CD4 T cells augment the mucous production in the lung and also reduce clearance of the virus. However, T regulatory cells (Treg) can reduce the RSV-induced immunopathology. Anna’s studies found that the Notch ligand, Delta-like 4 (Dll4) induces Tregs to mitigate the RSV immunopathology through a mechanism utilizing epigenetic modifications orchestrated by the domain-containing protein 3 (SMYD3). The results of her thesis may lead to future therapeutic targets for pulmonary and other mucosal inflammatory diseases.
Anna has had a very successful graduate tenure, with 4 publications and another paper submitted. In addition, she has garnered multiple awards, including:
Dr. Ting will continue her training with a postdoctoral research fellowship the in the laboratory of Dr. Jakob von Moltke at the University of Washington.
Congratulations, Anna, well done!
ON THE COVER
Breast team reviewing a patient's slide. (From left to right) Ghassan Allo, Fellow; Laura Walters, Clinical Lecturer; Celina Kleer, Professor. See Article |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Autopsy Technician draws blood while working in the Wayne County morgue. See Article |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Dr. Sriram Venneti, MD, PhD and Postdoctoral Fellow, Chan Chung, PhD investigate pediatric brain cancer. See Article |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Director of the Neuropathology Fellowship, Dr. Sandra Camelo-Piragua serves on the Patient and Family Advisory Council. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Residents Ashley Bradt (left) and William Perry work at a multi-headed scope in our new facility. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Dr. Kristine Konopka (right) instructing residents while using a multi-headed microscope. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Patient specimens poised for COVID-19 PCR testing. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Dr. Pantanowitz demonstrates using machine learning in analyzing slides. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
(Left to Right) Drs. Angela Wu, Laura Lamps, and Maria Westerhoff. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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ON THE COVER
Illustration representing the various machines and processing used within our labs. |
newsletter
INSIDE PATHOLOGYAbout Our NewsletterInside Pathology is an newsletter published by the Chairman's Office to bring news and updates from inside the department's research and to become familiar with those leading it. It is our hope that those who read it will enjoy hearing about those new and familiar, and perhaps help in furthering our research. CONTENTS
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MLabs, established in 1985, functions as a portal to provide pathologists, hospitals. and other reference laboratories access to the faculty, staff and laboratories of the University of Michigan Health System’s Department of Pathology. MLabs is a recognized leader for advanced molecular diagnostic testing, helpful consultants and exceptional customer service.
