Why the World Needs an Essential Diagnostics List

www.uofmhealth.org | 12 August

Our Director of Point-of-Care Testing and Associate Director of Chemical Pathology, Dr. Lee Schroeder, recently published Time for a Model List of Essential Diagnostics in the New England Journal of Medicine regarding the importance of having a list of essential diagnostic laboratory tests which could be used world wide as part of a strategy to combat diseases globally. The UM Health System featured his work to improve diagnostic testing worldwide, and we republish their report, by Kara Gavin, below. In addition, recently Forbes magazine has highlighted this valuable contribution to the world health effort in an excellent article, Why the World Needs An Essential Diagnostics List, written by Lee Schroeder, Timothy Amukele and Madhukar Pai.

Above Photo: Dried blood spots being collected in Kenya for early infant diagnosis of HIV. (by Timothy Amukele)

To improve the world’s health, experts call for a standard list of essential diagnostic tests

Similar to long-established list of essential medicines, it could help improve capacity and quality of testing in developing nations


ANN ARBOR, Mich. — In a western doctor’s office or hospital, patients don’t think twice about giving a blood or urine sample that can tell if they have a disease or infection, or show if their medicines are working. The samples get rushed to a testing lab with modern equipment that’s held to high quality standards.

But in developing nations, many of those tests aren’t available. Or if they are, doctors may not put much faith in them because of the state of their country’s testing labs.

And some of those tests – which can detect emerging viruses like Zika or Ebola – could make the difference in outbreaks that can quickly affect the rest of the world.

Now, a team of experts has put together a list of the key tests that every country should have available, with high quality standards, in hopes of changing this situation.

Writing in the New England Journal of Medicine, they put forth a list of tests that syncs with another, much more established list: the Model List of Essential Medicines, or EML, published by the World Health Organization.

For the last 40 years, the EML has guided billions of dollars in spending on more than 300 vital pharmaceuticals by government agencies, healthcare organizations, and charity groups worldwide. When a medicine makes it onto the list, it jumpstarts a global health funding mechanism to make sure the medicines flow to developing countries.

A parallel Model List of Essential Diagnostics, which the new paper proposes, could make the most of that spending. When performed correctly, these tests can help health teams figure out which of the EML medications a patient needs and at what dose, track their response to treatment, and monitor for medication toxicity.

“Efficient delivery of healthcare requires diagnostic testing,” says Lee F. Schroeder, M.D., Ph.D., lead author of the new paper and an assistant professor of pathology at the University of Michigan Medical School. “You can’t treat what you can’t test. This list includes the most critical tests for diagnosing conditions, monitoring drug effects and toxicity, reducing over-prescription of antibiotics, and enabling surveillance of infectious threats.”


Compiling the List

Schroeder and his colleagues, including Timothy Amukele, M.D., Ph.D. of Johns Hopkins University, scoured expert databases on diagnostic testing to determine which tests are needed to support the use of each medicine on the EML.

The resulting list includes 147 essential laboratory tests in 57 categories. A single diagnostic test can guide the use of many different EML drugs.

The paper includes a table of 19 test categories that can guide the use of 10 or more EML medicines including:

  • Accurate counts of different types of blood cells in a sample,which can directly affect the use of 136 different items on the EML list.
  • Accurate blood tests assessing liver toxicity, which can support the use of 104 EML drugs.
  • Accurate blood tests for kidney function, which should be used in conjunction with more than 80 items on the EML
  • Standardized use of microscope-based diagnostic tests, which can guide the best use of 85 essential medicines, most of them aimed at treating and preventing infectious disease.
  • Urinalysis, when performed well, can monitor the use of 64 EML drugs.
  • Tests that look for DNA signatures from an infectious microbe, or isolate and grow that microbe from a sample taken from a patient. These tests can make a difference in outbreaks and the use of 62 EMLs.

“Many developing countries have high quality central public health labs in large cities; the missing piece in global health is a network of smaller, but still high quality, labs throughout the country,” says Schroeder. Poor test quality, or inappropriate storage of testing materials, can erode doctors’ trust in test results.

In fact, a recent literature review by the WHO identified multiple studies reporting that between 2 and as many as 10 percent of diagnosed HIV patients in the developing world may not have ever been infected by HIV. Rather, these misdiagnoses were based on inappropriate use of diagnostic testing – leading people to believe they have the virus that causes AIDS when in fact they don’t.

In a recent study, Schroeder, Amukele and colleagues at a hospital that Johns Hopkins runs jointly with Makerere University in Kampala, Uganda evaluated diagnostic test availability in that city. While 822 labs offered malaria testing, only five offered testing that’s essential to long-term management of diabetes and avoidance of complications such as blindness, amputation, and kidney failure.

While it will take time and resources to ensure that developing nations have high quality testing capability for even some of the essential diagnostics, Schroeder predicts that it will prove cost-effective in the long run.

“The Model List of Essential Medicines is probably the single most important tool in global health,” he says. “We believe a list of essential diagnostics is long overdue and could amplify the impact of current global health investment.” Schroeder and his colleagues plans further research on the topic and hope to encourage the global health community to embrace the idea of the Model List of Essential Diagnostics.

In addition to Schroeder and Amukele, the paper’s authors are Jeannette Guarner, M.D., Ali Elbireer, Ph.D., M.B.A., and Philip E. Castle, Ph.D., M.P.H.


Reference: N Engl J Med 2016; 374:2511-2514 June 30, 2016 | View Reference

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