Derek Dang becomes Dr. Derek Dang
By Lynn McCain | March 20Molecular and Cellular Pathology graduate student, Derek Dang, successfully defended his thesis, “Beyond the Warburg Effect: A study of metabolic alterations in malignancies of the posterior fossa” on January 19, 2024, becoming Dr. Derek Dang.
Dang’s research focuses on MYC-driven Group 3 medulloblastomas (MB), which are aggressive pediatric brain cancers with a very poor prognosis. These tumors tend to be very heterogeneous, meaning there is a great deal of variety in the genetic or molecular properties of the tumors. Dang focused on the most common metabolic alteration found in MB, the MYC gene. In the past, researchers have focused directly on the MYC gene, without much success, so Dang decided to investigate further upstream. He found that these tumors depend not only on glucose-derived carbons for their metabolism, but also on mitochondrial metabolism. Mitochondrial metabolism utilizes an enzyme called DLAT to regulate a copper-dependent cell death mechanism, cuproptosis. Dang found that DLAT could be targeted via IDH1 inhibition, leading to cancer cell death. “These findings are important because they reveal multiple strategies that we can use to target elevated mitochondrial metabolism in Group 3 Medulloblastoma,” said Dang.
For the past five years, Dang has been a member of the Dr. Sriram Venneti laboratory. He selected the Venneti lab as he was interested in brain development and cancer. During his undergraduate years, he worked in the laboratory of Dr. Kathleen Millen, who studied malformations that occur during cerebellar development. In cancer, specific pathways which are important for proper development do not turn off as they should, leading to uncontrolled cell growth. When he joined the Venneti lab, he was able to expand upon what he had learned as an undergraduate.
“The biggest challenge in research is that biology is never as simple as you hope it will be. You need to be creative to answer some of these questions with experimental and technical approaches as well as the theoretical approaches. My mentor was able to help me think outside the box and consider alternative methods that could be driving the process,” explained Dang.
Some of Dang’s favorite times as an MCP student included participating in the Molecular and Cellular Pathology Research Symposia. “This is such a great celebration of all our research. I like the fact that they are all student run.” In addition, he also appreciates all the team bonding activities in the program, “We have a very tight-knit community here in the Pathology department, especially with the students. I enjoyed spending time with them doing community service events or going on the camping trip that we go on every summer. I have been able to be involved in a little bit of everything and to really connect with a lot of the students. I wish I had been more involved in teaching, though. I volunteered and taught middle schoolers and high schoolers, but I wish I had chosen to teach a college-level course.” Dang went on to address the overall program saying, “The MCP program has such a wide range of research opportunities. We can work on pretty much every disease or disease model you can think of. It has a very strong emphasis on becoming a well-rounded scientist. If you are interested in doing statistics or science writing, there are also opportunities for that. The student group is fantastic, and we are very supportive of each other.”
Now that Dang has completed his doctoral studies, he will soon be departing to complete a fellowship at the Centers for Disease Control. “I’ll be in Atlanta for a month starting in July for training, then in Milwaukee for a couple of years after that,” said Dang.
Please join us in congratulating Dr. Derek Dang on his achievements.
If you are interested in learning more about the MCP Graduate Program, click here or email Dr. Jeff Rual at jrual@med.umich.edu.
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