Mctp News Archive

Dr. Lakshmi (Priya) Kunju named Director of the Division of Anatomic Pathology
Feb 28, 2023

Dr. Lakshmi (Priya) Kunju named Director of the Division of Anatomic Pathology

It is with great pleasure that we announce Dr. Lakshmi (Priya) Kunju as our new Director of the Division of Anatomic Pathology (AP) effective Wednesday, March 1, 2023. We are grateful for all that Dr. Kunju brings to the table including her considerable experience with operations across the division and her willingness to jump in on short notice to ensure stability during this transition. She will work with department leaders and others to identify and recruit to her role as Section Head for Surgical Pathology and Medical Director of our gross room and histology laboratory. Please join us in congratulating Dr. Priya Kunju on her appointment as AP Director. Please also join us in thanking Dr. Liron Pantanowitz for his nearly 3 years as AP Director. He has been remarkably productive in his role and can be proud of a division that is among the VERY BEST team of AP faculty, staff, and learners in the world!

Rogel Researchers Receive $4M Through Prostate Cancer Foundations Inaugural TACTICAL Awards Program
Jan 10, 2023

Rogel Researchers Receive $4M Through Prostate Cancer Foundations Inaugural TACTICAL Awards Program

The University of Michigan Rogel Cancer Center researchers received one of the Prostate Cancer Foundation’s four inaugural Class of 2022 TACTICAL (Therapy ACceleration To Intercept Cancer Lethality) Award. This $30 million program will support cross-disciplinary pioneering research toward the goal of developing 21st Century therapies for the most life-threatening form of prostate cancer [...]

Clear Cell Renal Cell Carcinoma study results published
Jan 6, 2023

Clear Cell Renal Cell Carcinoma study results published

Members of the University of Michigan Department of Pathology and Michigan Center for Translational Pathology, in collaboration with the Clinical Proteomic Tumor Analysis Consortium, recently published a large study on clear cell renal cell carcinomas (ccRCCs), which represent about 75% of the RCC cases and account for the most RCC-associated deaths. This study set out to create a comprehensive profile of ccRCC, combining histologic and molecular profiles. By analyzing both the microscopic cell structures and the genetic makeup of the cells, these researchers discovered significant intratumoral heterogeneity in 90% of ccRCCs. This indicates that ccRCCs originate from multiple tumor cell lines, called tumor subclones, that may become metastatic and could independently influence response to therapies. Through this study, the team was able to molecularly stratify aggressive histopathic subtypes, which may lead to more effective treatment strategies for patients and improved survival.

Cytomorphology and IHC helps diagnose transformed metastatic prostate cancer
Oct 27, 2022

Cytomorphology and IHC helps diagnose transformed metastatic prostate cancer

A research team from the Michigan Center for Translational Pathology undertook a study to illustrate how careful assessment of cytologic and biomarker features may provide physicians with information on Metastatic Prostatic Cancer (MCP) patients’ prognosis and the best therapies to consider [...]

Researchers Find Link Between Genetic Mutations and Cancer Treatment Resistance
Jul 26, 2022

Researchers Find Link Between Genetic Mutations and Cancer Treatment Resistance

Patients with relapsed multiple myeloma are resistant to commonly used treatments. Researchers are one step closer to understanding the genetic reason why.

Using Artificial Intelligence to predict ERG Gene Fusion in Prostate Cancer
May 10, 2022

Using Artificial Intelligence to predict ERG Gene Fusion in Prostate Cancer

The role of artificial intelligence (AI) in healthcare continues to expand. In a recent issue of BMC Cancer, Dr. Vipulkumar Dadhania (first author) and colleagues published a result of their study Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer. The expert team from the Michigan Center for Translational Pathology developed a deep-learning-based model to predict ERG genomic rearrangements in prostatic adenocarcinomas using only H&E-stained digital slides [...]

Parolia Selected For Harold Weintraub Graduate Student Award
Mar 1, 2022

Parolia Selected For Harold Weintraub Graduate Student Award

Please join us in congratulating Dr. Abhijit Parolia on being selected for the 2022 Harold Weintraub Graduate Student Award. The award, established by the Fred Hutchinson Cancer Research Center, is given yearly and recognizes outstanding achievement during graduate studies in the biological sciences [...]

Arul Chinnaiyan, MD, PhD, selected for the Sjöberg Prize in Cancer Research
Feb 11, 2022

Arul Chinnaiyan, MD, PhD, selected for the Sjöberg Prize in Cancer Research

The Royal Swedish Academy of Sciences, which also awards the Nobel Prizes, announced today that Arul Chinnaiyan, MD, PhD, S.P. Hicks Professor of Pathology and Urology at Michigan Medicine and Director of the Michigan Center for Translational Pathology, has been selected as [...]

Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers
Jan 4, 2022

Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers

A chromatin degrader stops transcription factors from driving cancer, which may serve as a potential treatment approach for over 90% of prostate cancers.

Inside the COVID Pandemic: A Laboratory Perspective
Nov 29, 2021

Inside the COVID Pandemic: A Laboratory Perspective

The SARS-CoV-2 virus brought lab testing to the headlines. Learn how Michigan Medicine Pathology responded to this unprecedented challenge.

TRIM63 - What is it?  (Hint:  Not a weight-loss product)
Aug 9, 2021

TRIM63 - What is it? (Hint: Not a weight-loss product)

Dr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology  [...]

Researchers Uncover Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer
Aug 3, 2021

Researchers Uncover Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer

Findings offer clues to why some types of renal cell carcinoma respond to immunotherapy while others do not — it’s a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

Analysis Reveals How Kidney Cancer Develops and Responds to Treatment
Jun 10, 2021

Analysis Reveals How Kidney Cancer Develops and Responds to Treatment

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]

Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer
May 12, 2021

Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer

Stopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.

Arul Chinnaiyan, MD, PhD, Recognized for Outstanding Research
May 7, 2021

Arul Chinnaiyan, MD, PhD, Recognized for Outstanding Research

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “Exploring Precision Oncology: from Gene Fusions to Related Genetic Drivers“ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021 [...]

Arul Chinnaiyan, MD, PhD Recognized for Outstanding Research
May 3, 2021

Arul Chinnaiyan, MD, PhD Recognized for Outstanding Research

Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “ “ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021.

Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype
Apr 14, 2021

Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.

New Assay For Early Detection of Aggressive Prostate Cancers Developed
Apr 13, 2021

New Assay For Early Detection of Aggressive Prostate Cancers Developed

A new study, led by U-M graduate in molecular and cellular pathology Dr. Andi Cani, was just published in European Urology Oncology. The publication focuses on the development of a whole-urine, multiplexed, next-generation RNA-sequencing assay that is used for the early detection of aggressive forms of prostate cancer [...]

How Useful is Next-Generation Sequencing for Patients with Advanced Cancer?
Apr 8, 2021

How Useful is Next-Generation Sequencing for Patients with Advanced Cancer?

Patients with cancers of unknown origin greatly benefited from next-generation sequencing; widespread inherited cancer risk also suggests broad utility, a study finds.

"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra
Mar 9, 2021

"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra

Dr. Mehra discusses his career path and how he arrived at Michigan Medicine in our latest Careers in Pathology video.