Rual Lab

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Dr. Jean-François (Jeff) Rual, Ph.D.

Assistant Professor

Email: jrual@umich.edu

Phone: 734-764-6975

Dr. Jean-Francois (Jeff) Rual received a B.S. in Biochemistry and Molecular Biology from the University of Nice Sophia-Antipolis (Nice, France) in 1999 and a M.S. in Microbiology and Virology from the Pasteur Institute (Paris, France) and the  University of Nice Sophia-Antipolis  in 2000. He then went on to receive a M.S. in Bioinformatics from the University of Notre Dame de la Paix (Namur, Belgium) in 2001. He completed his graduate research studies in the  Department of Genetics at Harvard Medical School  (Boston, MA) in the laboratory of Prof. Marc Vidal and received his Ph.D. from the  University of Notre Dame de la Paix  in Molecular Biology in 2005. After two years as Project Leader at the Center for Cancer Systems Biology (CCSB) at Harvard Medical School under the direction of Prof. Marc Vidal (2005-2007), Dr. Rual joined the laboratory of Prof. Spyros Artavanis-Tsakonas in the Department of Cell Biology at Harvard Medical School (2007-2011). His post-doctoral training in the Artavanis-Tsakonas Lab was supported by a José Carreras International Leukemia Foundation Fellowship Award. In July 2011, Dr. Rual joined the faculty of the Department of Pathology at the University of Michigan as an Assistant Professor and is an American Society of Hematology (ASH) Scholar (2013-2015).   

 


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Caryn Crane

Administrative Assistant

Email:  ccaryn@med.umich.edu

Phone: 734-764-6683

Fax: 734-763-8764

Caryn joined the Rual Lab as Administrative Assistant in August 2016. 

 

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Dr. Honglai Zhang

Research Specialist

Email:  honglaiz@med.umich.edu

Phone: 734-764-8736

Dr. Honglai Zhang joined the Rual Lab as a Research Specialist in May 2013.  He is investigating the biomedical relevance of the candidate HOXA9 co-factors identified in our proteomic pipeline by using cell-based and in vivo models of leukemogenesis. Dr. Honglai Zhang  is also investigating the biomedical relevance of the candidate Notch  and  Hedgehog  pathway modulators identified in our proteomic pipeline by using cell-based and in vivo models of brain tumorigenesis.
 

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Claire Peabody

M-Cubed Scholar

Claire joined the Rual lab in June 2017 as part of the M-Cubed Scholars Program. She works on the in vivo characterization of modulators of Hedgehog signaling in mouse models of brain tumorigenesis.

 

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Philip Huang
Undergraduate Student
Phone: 734-764-8736
Philip joined the Rual lab in November 2018. He works on the in vivo characterization of modulators of Notch signaling in mouse models of brain and breast tumorigenesis.
 

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Rashmi Budhathoki
St. Baldrick’s Summer Fellow
Phone: 734-764-8736
 
Rashmi joined the Rual lab in March 2019 as a Visiting Research Scholar from the Nobel College, Kathmandu, Nepal. She obtained a St. Baldrick’s Summer Fellowship from the St. Baldrick's Foundation to pursue her work in the Rual lab for the in vivo characterization of modulators of Notch signaling in mouse models of brain tumorigenesis.
 

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Danfeng Luo

Visiting Research Scholar
Phone: 734-764-8736
 
Dr. Danfeng Luo, MD/PhD, Associate Chief Physician of Division of Obstetrics and Gynecology, Tongji Medical College, Huazhong University, joined the Rual lab in September 2019 as a Visiting Research Scholar. He is working on the “L3MBTL3 in breast cancer” project.
 
 
 
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Former Lab Members

 

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Dr. Sung-Soo Park

Research Fellow

Email: parksung@umich.edu

Phone: 734-764-8736

Dr. Sung-Soo Park joined the Rual Lab as a Research Fellow in November 2011. He investigated the molecular network in which Notch signaling pathway proteins are involved using a MS-based approaches. Sung-Soo now works in the biotech company Helixmith in Seoul, South Korea.


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Ester Calvo Fernandez

St. Baldrick’s Staff Giving Campaign Summer Fellow

Ester worked in the Rual lab from January 2018 to June 2019 as a Visiting Research Scholar from the University of Barcelona, Spain. She obtained the St. Baldrick’s Staff Giving Campaign Summer Fellowship from the St. Baldrick's Foundation to pursue her work in the Rual lab for the in vivo characterization of modulators of Notch signaling in mouse models of brain tumorigenesis. Ester joined the Columbia University Medical Center in June 2019 as a PhD Candidate in the Pathobiology and Mechanisms of Disease PhD Program.


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Sarah Cooke

M-Cubed Scholar

Sarah worked in the Rual lab from June 2017 to August 2017 as part of the M-Cubed Scholars Program. She worked on the in vitro characterization of newly identified RBPJ interactors for their ability to modulate Notch signaling.


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Dr. Tao Xu

Research Fellow

Dr. Tao Xu worked in the Rual lab from August 2011 to June 2017 as a Research Fellow. He investigated the molecular networks in which Notch  and Hedgehog signaling pathway proteins are involved using the Y2H system. Tao is now a Senior Analyst at the University of Michigan School of Public Health.

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Jessica Erickson

Undergraduate Student 

Jessica worked in the Rual lab from October 2016 to May 2017 as part of the Undergraduate Research Opportunity Program (UROP). She worked on the in vivo characterization of modulators of Hedgehog signaling in mouse models of brain tumorigenesis.


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Alaina Horwood

Undergraduate Student

Alaina worked in the Rual lab from September 2015 to May 2016 as part of the Undergraduate Research Opportunity Program (UROP). She worked on the molecular characterization of modulators of Hedgehog signaling.


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Justin Yoon

Undergraduate Student

Justin worked in the Rual lab from September 2015 to November 2017 as part of the Undergraduate Research Opportunity Program (UROP). He worked on the in vivo characterization of modulators of Notch signaling in mouse models of brain tumorigenesis. Justin joined the class of 2022 at the Case Western Reserve University School of Medicine.


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Arinze Ubadike

Community College Summer Research Fellow

Arinze worked in the Rual lab from June 2014 to April 2015 as a part of the Community College Summer Research Fellowship Program .


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Ryan DeAngelis

Cancer Research Summer Intership Intern

Ryan worked in the Rual lab from June 2014 to April 2015 as a part of the Cancer Research Summer Intership Program (CaRSIP) .


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Kimberly Ha

Undergraduate Student

Kimberly joined the Rual lab in October 2011 and worked in the Rual lab for 3 years.  She worked  on the characterization of  Notch -related protein-protein interactions using the Y2H system.  She is now a Graduate Student in the  Doctor of Pharmacy program at the University of Illinois , Chicago, IL.  


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Rita Ching-Ting Chao

Research Assistant

Rita joined the Rual Lab from October 2012 to June 2014 as a Research Assistant.


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Eléna Milon

Graduate Student

Eléna worked in the Rual lab from July 2012 to February 2013 as a visiting Graduate Student from ENSTBB , at the University of Bordeaux, France. During her stay in the lab, Eléna  worked on the characterization of Notch -related protein-protein interactions discovered using the Y2H system.  Eléna is now working as  a Market Researcher at Prescient Life Sciences , a pharmaceutical consultancy based in London, UK.


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Anji Li

UROP Undergraduate Student

As part of the  Undergraduate Research Opportunity Program (UROP), Anji worked in the Rual lab from September 2012 to March 2013. She works on the characterization of the Notch molecular network using an AP-MS approach.


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Mahnoor Asghar

UROP Undergraduate Student

Mahnoor joined the Rual lab from October 2011 to April 2012 as part of the  Undergraduate Research Opportunity Program (UROP) . She worked on the characterization of HOXA9-related protein-protein interactions using the Y2H system.